{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/ann-stock-lab\/?page_id=365"},"modified":"2025-06-12T20:15:08","modified_gmt":"2025-06-12T20:15:08","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/ann-stock-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Two-Component Systems<\/strong><\/h3>\n

Two-Component Systems (TCSs) are a central theme in our research projects. In most bacteria, several dozen TCSs provide adaptive responses to environmental stimuli, regulating processes such as nutrient utilization, swimming behavior, biofilm formation, sporulation, or virulence factor expression. TCS signaling utilizes a core phosphotransfer pathway between two conserved components. In canonical TCSs, a histidine kinase that is regulated by environmental stimuli autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to an aspartate residue in a response regulator protein, promoting an active conformation that elicits a response. Variable input domains in histidine kinases and variable output domains in response regulators provide a versatile scheme that can be used to couple almost any physical or chemical stimuli to any output response.<\/p>\n

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Two-Component Systems Two-Component Systems (TCSs) are a central theme in our research projects. In most bacteria, several dozen TCSs provide adaptive responses to environmental stimuli, regulating processes such as nutrient … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResearch - Ann Stock Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/ann-stock-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Ann Stock Laboratory\" \/>\n<meta property=\"og:description\" content=\"Two-Component Systems Two-Component Systems (TCSs) are a central theme in our research projects. 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