{"id":363,"date":"2020-07-09T16:51:59","date_gmt":"2020-07-09T16:51:59","guid":{"rendered":"http:\/\/sites.rutgers.edu\/astrof-lab\/?page_id=363"},"modified":"2025-08-20T14:35:03","modified_gmt":"2025-08-20T14:35:03","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/astrof-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/sophie.astrof.2\/bibliography\/public\/<\/a><\/span><\/p>\n

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2023 – 2025<\/strong><\/h3>\n
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Bhaskar A, Astrof, S. Identification of novel genes regulating the development of the palate<\/a>. Developmental Dynamics 2025 Aug 2:10.1002\/dvdy.70066<\/p>\n

Arriagada C, Lin E, Schonning M, Astrof S. Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development<\/a>. Developmental Cell 2025 Jan 6;60(1):62-84.e7.<\/span>doi: 10.1016\/j.devcel.2024.09.017. <\/span> Epub 2024 Oct 15. <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Ramirez A, Vyzas CA, Zhao H, Eng K, Degenhardt K, Astrof S. Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease<\/a>. Circulation Research Volume\u00a0134<\/span>,\u00a0<\/span>Issue\u00a010<\/span>,\u00a0<\/span>10 May 2024<\/span>;\u00a0Pages\u00a0e112-e132<\/span>, DOI: https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322767<\/a><\/p>\n

Alexander BE, Zhao H, and Astrof S. SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development.<\/a> Developmental Dynamics 2024 Jan;253(1):119-143. doi: 10.1002\/dvdy.652<\/span><\/p>\n

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Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A. Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.<\/a> Developmental Biology 499:10-21, 2023
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Melamed S, Zaffryar-Eilot S, Nadjar-Boger E, Aviram R, Zhao H, Yaseen-Badarne W, Kalev-Altman R, Sela-Donenfeld D, Lewinson O, Astrof S, Hasson P, Wolfenson H. Initiation of fibronectin fibrillogenesis is an enzyme-dependent process.<\/a><\/span> Cell Reports 2023 May 4;42(5):112473. doi: 10.1016\/j.celrep.2023.112473. <\/span>PMID:\u00a037148241<\/span><\/span><\/p>\n

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2020 – 2022
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Tomer D, Arriagada C, Munshi S, Alexander BE, French B, Vedula P, Caorsi V, House A, Guvendiren M, Kashina A, Schwarzbauer JE, Astrof S. A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.<\/a> Journal of Cell Science (2022) 135, jcs260120<\/span>. DOI: 10.1242\/jcs.260120<\/a>.\u00a0 \u00a0<\/span>See also: Research Highlight<\/a> and First author interview<\/a><\/span><\/p>\n<\/div>\n

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Metikala S, Warkala M, Casie Chetty S, Chestnut B, Rufin Florat D, Plender E, Nester O, Koenig AL, Astrof S, Sumanas S. Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. <\/a><\/span><\/span>Developmental Cell 2022 Mar 28;57(6):767-782.e6. DOI: 10.1016\/j.devcel.2022.02.015. Epub 2022 Mar 10.<\/span>PMID:\u00a035276066<\/span><\/span><\/p>\n<\/div>\n

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Warkala M, Chen D, Ramirez A, Jubran A, Schonning MJ, Wang X, Zhao H, Astrof S. Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development<\/a>. Circulation Research Volume 128, Issue 3, 5 February 2021; Pages e27-e44 https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.318200<\/a><\/span>. See also: Commentary<\/a> and Meet the first author<\/a><\/span><\/p>\n

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Ramirez A, Astrof S.\u00a0Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction.<\/a> J Vis Exp.\u00a02020 Mar 31;(157).\u00a0doi: 10.3791\/60797.\u00a0PubMed PMID: 32310236; PubMed Central PMCID: PMC7216781.<\/div>\n

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2010 – 2019<\/strong><\/p>\n

Choi S, Pfleger J, Jeon YH, Yang Z, He M, Shin H, Sayed D,\u00a0Astrof S, Abdellatif M. Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications.<\/a><\/span>Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194436. doi: 10.1016\/j.bbagrm.2019.194436. Epub 2019 Nov 1.<\/span>PMID:\u00a031682939<\/span><\/span><\/p>\n

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Wang X, Astrof S.\u00a0<\/span>Isolation of Mouse Cardiac Neural Crest Cells and Their Differentiation into Smooth Muscle Cells.\u00a0<\/a>Bio Protoc<\/span>.\u00a02017 Sep 5;<\/span>7<\/span>(17)<\/span>.\u00a0doi: 10.21769\/BioProtoc.2530.\u00a0<\/span>PubMed PMID: 28979923<\/span>; PubMed Central PMCID: PMC5624110<\/span>.<\/p>\n<\/div>\n

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Wang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S.\u00a0<\/span>Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field.\u00a0<\/a>Dev Biol<\/span>.\u00a02017 Jan 15;<\/span>421<\/span>(2)<\/span>:108-117<\/span>.\u00a0doi: 10.1016\/j.ydbio.2016.12.010.\u00a0<\/span>Epub 2016 Dec 9.\u00a0<\/span>PubMed PMID: 27955943<\/span>; PubMed Central PMCID: PMC5221477<\/span>.<\/p>\n<\/div>\n

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Wang X, Astrof S. <\/span>Neural crest cell-autonomous roles of fibronectin in cardiovascular development.\u00a0<\/a>Development<\/span>.\u00a0<\/span>2016 Jan 1;<\/span>143<\/span>(1)<\/span>:88-100<\/span>.\u00a0<\/span>doi: 10.1242\/dev.125286.\u00a0<\/span>Epub 2015 Nov 9.\u00a0<\/span>PubMed PMID: 26552887<\/span>; PubMed Central PMCID: PMC4725203<\/span>.<\/span><\/p>\n<\/div>\n

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Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S.\u00a0<\/span>Fibronectin signals through integrin \u03b15\u03b21 to regulate cardiovascular development in a cell type-specific manner.\u00a0<\/a>Dev Biol<\/span>.\u00a02015 Nov 15;<\/span>407<\/span>(2)<\/span>:195-210<\/span>.\u00a0doi: 10.1016\/j.ydbio.2015.09.016.\u00a0<\/span>Epub 2015 Oct 3.\u00a0<\/span>PubMed PMID: 26434918<\/span>; PubMed Central PMCID: PMC5312697<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Liang D, Wang X, Mittal A, Dhiman S, Hou SY, Degenhardt K, Astrof S.\u00a0<\/span>Mesodermal expression of integrin \u03b15\u03b21 regulates neural crest development and cardiovascular morphogenesis.\u00a0<\/a>Dev Biol<\/span>.\u00a02014 Nov 15;<\/span>395<\/span>(2)<\/span>:232-44<\/span>.\u00a0doi: 10.1016\/j.ydbio.2014.09.014.\u00a0<\/span>Epub 2014 Sep 19.\u00a0<\/span>PubMed PMID: 25242040<\/span>; PubMed Central PMCID: PMC4252364<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Pulina M, Liang D, Astrof S.\u00a0<\/span>Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions.\u00a0<\/a>Biol Open<\/span>.\u00a02014 Jun 13;<\/span>3<\/span>(7)<\/span>:583-90<\/span>.\u00a0doi: 10.1242\/bio.20148243.\u00a0<\/span>PubMed PMID: 24928429<\/span>; PubMed Central PMCID: PMC4154294<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Villegas SN, Rothov\u00e1 M, Barrios-Llerena ME, Pulina M, Hadjantonakis AK, Le Bihan T, Astrof S, Brickman JM.\u00a0<\/span>PI3K\/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix.\u00a0<\/a>Elife<\/span>.\u00a02013 Dec 24;<\/span>2<\/span>:e00806<\/span>.\u00a0doi: 10.7554\/eLife.00806.\u00a0<\/span>PubMed PMID: 24368729<\/span>; PubMed Central PMCID: PMC3871052<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Mittal A, Pulina M, Hou SY, Astrof S.\u00a0<\/span>Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis.\u00a0<\/a>Dev Biol<\/span>.\u00a02013 Sep 1;<\/span>381<\/span>(1)<\/span>:73-82<\/span>.\u00a0doi: 10.1016\/j.ydbio.2013.06.010.\u00a0<\/span>Epub 2013 Jun 17.\u00a0<\/span>PubMed PMID: 23791818<\/span>; PubMed Central PMCID: PMC3833817<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S.\u00a0<\/span>Essential roles of fibronectin in the development of the left-right embryonic body plan.\u00a0<\/a>Dev Biol<\/span>.\u00a02011 Jun 15;<\/span>354<\/span>(2)<\/span>:208-20<\/span>.\u00a0doi: 10.1016\/j.ydbio.2011.03.026.\u00a0<\/span>Epub 2011 Apr 3.\u00a0<\/span>PubMed PMID: 21466802<\/span>; PubMed Central PMCID: PMC3225965<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Mittal A, Pulina M, Hou SY, Astrof S.\u00a0<\/span>Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest.\u00a0<\/a>Mech Dev<\/span>.\u00a02010 Sep-Dec;<\/span>127<\/span>(9-12)<\/span>:472-84<\/span>.\u00a0doi: 10.1016\/j.mod.2010.08.005.\u00a0<\/span>Epub 2010 Aug 31.\u00a0<\/span>PubMed PMID: 20807571<\/span>; PubMed Central PMCID: PMC3233353<\/span>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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2004 – 2009<\/strong><\/p>\n

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Astrof S, Hynes RO.\u00a0<\/span>Fibronectins in vascular morphogenesis<\/a>. Angiogenesis<\/span>.\u00a02009;<\/span>12<\/span>(2)<\/span>:165-75<\/span>.\u00a0doi: 10.1007\/s10456-009-9136-6.\u00a0<\/span>Epub 2009 Feb 14.\u00a0<\/span>Review.\u00a0<\/span>PubMed PMID: 19219555<\/span>; PubMed Central PMCID: PMC2716138<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO.\u00a0<\/span>A system for Cre-regulated RNA interference in vivo.\u00a0<\/a>Proc Natl Acad Sci U S A<\/span>.\u00a02008 Sep 16;<\/span>105<\/span>(37)<\/span>:13895-900<\/span>.\u00a0doi: 10.1073\/pnas.0806907105.\u00a0<\/span>Epub 2008 Sep 8.\u00a0<\/span>PubMed PMID: 18779577<\/span>; PubMed Central PMCID: PMC2532697<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Astrof S, Crowley D, Hynes RO.\u00a0<\/span>Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin.\u00a0<\/a>Dev Biol<\/span>.\u00a02007 Nov 1;<\/span>311<\/span>(1)<\/span>:11-24<\/span>.\u00a0doi: 10.1016\/j.ydbio.2007.07.005.\u00a0<\/span>Epub 2007 Jul 12.\u00a0<\/span>PubMed PMID: 17706958<\/span>; PubMed Central PMCID: PMC2080666<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Astrof S, Kirby A, Lindblad-Toh K, Daly M, Hynes RO.\u00a0<\/span>Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four.\u00a0<\/a>Mech Dev<\/span>.\u00a02007 Aug;<\/span>124<\/span>(7-8)<\/span>:551-8<\/span>.\u00a0doi: 10.1016\/j.mod.2007.05.004.\u00a0<\/span>Epub 2007 Jun 2.\u00a0<\/span>PubMed PMID: 17628448<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Matuskova J, Chauhan AK, Cambien B, Astrof S, Dole VS, Piffath CL, Hynes RO, Wagner DD.\u00a0<\/span>Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles.\u00a0<\/a>Arterioscler Thromb Vasc Biol<\/span>.\u00a02006 Jun;<\/span>26<\/span>(6)<\/span>:1391-6<\/span>.\u00a0doi: 10.1161\/01.ATV.0000216282.58291.c6.\u00a0<\/span>Epub 2006 Mar 9.\u00a0<\/span>PubMed PMID: 16528004<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Astrof S, Crowley D, George EL, Fukuda T, Sekiguchi K, Hanahan D, Hynes RO.\u00a0<\/span>Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.\u00a0<\/a>Mol Cell Biol<\/span>.\u00a02004 Oct;<\/span>24<\/span>(19)<\/span>:8662-70<\/span>.\u00a0doi: 10.1128\/MCB.24.19.8662-8670.2004.\u00a0<\/span>PubMed PMID: 15367684<\/span>; PubMed Central PMCID: PMC516752<\/span>.<\/p>\n<\/div>\n

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1998 – 2002<\/strong><\/h3>\n

Snitkovsky S, Young JA.\u00a0<\/span>Targeting retroviral vector infection to cells that express heregulin receptors using a TVA-heregulin bridge protein.\u00a0<\/a>Virology<\/span>.\u00a02002 Jan 5;<\/span>292<\/span>(1)<\/span>:150-5<\/span>.\u00a0doi: 10.1006\/viro.2001.1314.\u00a0<\/span>PubMed PMID: 11878917<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Snitkovsky S, Niederman TM, Mulligan RC, Young JA.\u00a0<\/span>Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein.\u00a0<\/a>J Virol<\/span>.\u00a02001 Feb;<\/span>75<\/span>(3)<\/span>:1571-5<\/span>.\u00a0doi: 10.1128\/JVI.75.3.1571-1575.2001.\u00a0<\/span>PubMed PMID: 11152532<\/span>; PubMed Central PMCID: PMC114065<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Snitkovsky S, Niederman TM, Carter BS, Mulligan RC, Young JA.\u00a0<\/span>A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor.\u00a0<\/a>J Virol<\/span>.\u00a02000 Oct;<\/span>74<\/span>(20)<\/span>:9540-5<\/span>.\u00a0doi: 10.1128\/jvi.74.20.9540-9545.2000.\u00a0<\/span>PubMed PMID: 11000224<\/span>; PubMed Central PMCID: PMC112384<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Boerger AL, Snitkovsky S, Young JA.\u00a0<\/span>Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.\u00a0<\/a>Proc Natl Acad Sci U S A<\/span>.\u00a01999 Aug 17;<\/span>96<\/span>(17)<\/span>:9867-72<\/span>.\u00a0doi: 10.1073\/pnas.96.17.9867.\u00a0<\/span>PubMed PMID: 10449786<\/span>; PubMed Central PMCID: PMC22302<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Snitkovsky S, Young JA.\u00a0<\/span>Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein.\u00a0<\/a>Proc Natl Acad Sci U S A<\/span>.\u00a01998 Jun 9;<\/span>95<\/span>(12)<\/span>:7063-8<\/span>.\u00a0doi: 10.1073\/pnas.95.12.7063.\u00a0<\/span>PubMed PMID: 9618539<\/span>; PubMed Central PMCID: PMC22739<\/span>.<\/p>\n<\/div>\n<\/div>\n

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Contact Me<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/sophie.astrof.2\/bibliography\/public\/ 2023 – 2025 Bhaskar A, Astrof, S. Identification of novel genes regulating the development of the palate. Developmental Dynamics 2025 Aug 2:10.1002\/dvdy.70066 Arriagada C, Lin E, Schonning M, Astrof … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-363","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/pages\/363"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/comments?post=363"}],"version-history":[{"count":105,"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/pages\/363\/revisions"}],"predecessor-version":[{"id":1355,"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/pages\/363\/revisions\/1355"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/astrof-lab\/wp-json\/wp\/v2\/media?parent=363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}