{"id":762,"date":"2013-12-20T14:44:21","date_gmt":"2013-12-20T14:44:21","guid":{"rendered":"http:\/\/sites.rutgers.edu\/centerfordermalresearch\/?p=762"},"modified":"2019-10-15T16:47:57","modified_gmt":"2019-10-15T16:47:57","slug":"vibrational-spectroscopy-microspectroscopic-imaging","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/centerfordermalresearch\/vibrational-spectroscopy-microspectroscopic-imaging\/","title":{"rendered":"Dr. Richard Mendelsohn Presents: Vibrational Spectroscopy and Microspectroscopic Imaging: Introduction and Applications to Skin Biophysics and Pharmacology"},"content":{"rendered":"

Part of the CDR Fall 2013 Seminar Series<\/strong><\/p>\n

In the world of skin research, where a drug\u2019s efficacy often depends on how well it can travel through the skin, new analysis technologies need always be developed to improve researchers\u2019 understanding of what happens beneath our skin.\u00a0 So, in an effort to keep our CDR members up-to-date with the most novel non-invasive approaches, we invited Dr. Richard Mendelsohn to host a talk at the center.<\/p>\n

Dr. Mendelsohn is a spectroscopist by training and recipient of the 2012 Gold Medal awarded by the Society for Applied Spectroscopy. In his talk, he discussed both IR and Raman uses for the in-vitro evaluation of drug penetration through the skin. Specifically, he discussed how wide-field IR spectroscopy allows us to map out the constituents of the stratum corneum \u2013 the primary barrier for drug diffusion through the skin. This mapping gives way to study and possibly predict the permeability of formulations by assessing the skin structure and its interactions with potential drugs via hydrogen bonding and lamellar structure formation.<\/p>\n

Next, he talked about his laboratory\u2019s exciting results with the use of confocal Raman for depth profiling of drugs, pro-drugs and permeation enhancers. Even more, he presented results that showed how he could track the enzymatic hydrolysis of a pro-drug through the skin!\u00a0 This now activated anticancer pro-drug had an increasing permeability through the skin.<\/p>\n

Finally by the end of the night we all arrived at the conjecture that increasing skin permeability is still a challenge, but these tools definitely give way to study skin structure and its components in a whole new (and more efficient) way.<\/p>\n","protected":false},"excerpt":{"rendered":"

Part of the CDR Fall 2013 Seminar Series In the world of skin research, where a drug\u2019s efficacy often depends on how well it can travel through the skin, new … Read More<\/a><\/p>\n","protected":false},"author":523,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-762","post","type-post","status-publish","format-standard","hentry","category-seminars"],"acf":[],"yoast_head":"\nDr. Richard Mendelsohn Presents: Vibrational Spectroscopy and Microspectroscopic Imaging: Introduction and Applications to Skin Biophysics and Pharmacology - Center For Dermal Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/centerfordermalresearch\/vibrational-spectroscopy-microspectroscopic-imaging\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Richard Mendelsohn Presents: Vibrational Spectroscopy and Microspectroscopic Imaging: Introduction and Applications to Skin Biophysics and Pharmacology - Center For Dermal Research\" \/>\n<meta property=\"og:description\" content=\"Part of the CDR Fall 2013 Seminar Series In the world of skin research, where a drug\u2019s efficacy often depends on how well it can travel through the skin, new … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/centerfordermalresearch\/vibrational-spectroscopy-microspectroscopic-imaging\/\" \/>\n<meta property=\"og:site_name\" content=\"Center For Dermal Research\" \/>\n<meta property=\"article:published_time\" content=\"2013-12-20T14:44:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-10-15T16:47:57+00:00\" \/>\n<meta name=\"author\" content=\"Bozena B. 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