Most of us have experienced the problem of skin inflammation whether it was sensitivity to a new topically applied cream or a nasty insect bite. We usually then go to the local pharmacy and purchase a steroid preparation perhaps containing hydrocortisone, in addition a local anesthetic such as lidocaine and maybe an antihistamine. Inflammation as a biochemical process is complex with multiple pathways and outcomes (pain, redness, edema, etc.) and is also part of so many dermatological diseases (dermatitis, oxidative stress, etc.).<\/p>\n
On\u00a0Monday August 11th<\/strong>\u00a0at 5.30pm at Rutgers Life Sciences Building, we host our Center for Dermal Research seminar speaker Michael Southall, Ph.D. who is the Research Director & Fellow at Johnson and Johnson Consumer & Personal Products Worldwide (CPPW) and who comes to us with a wealth of experience in skin inflammation research. Dr. Southall has been twice awarded the Johnson Medal, the highest scientific recognition at J & J for excellence in research. He has published over 40 peer-reviewed papers and book chapters on inflammation, oxidative stress and natural products and is an inventor on 14 granted patents and 60 patent applications.<\/p>\n Dr. Southall will talk to us about sertaconazole nitrate, a topical antifungal agent that was found to possess anti-inflammatory properties. The way this compound works has been elucidated by the J &J group led by Dr. Southall and it was found that prostaglandin E2 (PGE2) was elevated in sertaconazole treated mice. The mechanism of action was also identified as involving the p38-cyclooxygenase-2- PGE2 signaling pathway in skin. This should be an interesting lecture and I hope to see you there.<\/p>\n","protected":false},"excerpt":{"rendered":"