{"id":170,"date":"2017-12-22T18:13:36","date_gmt":"2017-12-22T18:13:36","guid":{"rendered":"http:\/\/sites.rutgers.edu\/professor-example\/?page_id=170"},"modified":"2025-08-22T15:19:15","modified_gmt":"2025-08-22T15:19:15","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/charles-roth\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<ol>\n<li>Varela-Soler Y, Xu W, Lima MRN, McDonald J, Jagpal SK, Kirn TJ, Hussain S, Devore DI, Roth CM. Antimicrobial loaded graft-copolymer nanoparticles for treatment of <em>Pseudomonas aeruginosa<\/em> infections. <em>bioRxiv<\/em>, 2025; <a href=\"https:\/\/doi.org\/10.1101\/2025.07.03.663093\">https:\/\/doi.org\/10.1101\/2025.07.03.663093<\/a>. Also submitted for peer-reviewed publication.<\/li>\n<li>Ganesh SR, <strong>Roth CM<\/strong>, Parekkadan B. Simulating interclonal interactions in diffuse large B-cell lymphoma. <em>Bioengineering<\/em>, 2023; 10(12):1360; <a href=\"https:\/\/doi.org\/10.3390\/bioengineering10121360\">https:\/\/doi.org\/10.3390\/bioengineering10121360<\/a>.<\/li>\n<li><a href=\"https:\/\/www.mdpi.com\/2227-9059\/11\/8\/2316\">Roychowdhury S, <strong>Roth CM<\/strong>. Pharmacodynamic model of the dynamic response of <em>Pseudomonas aeruginosa<\/em> biofilms to drug treatments. <em>Biomedicines<\/em>, 2023; 11:2316; doi: 10.3390\/biomedicines11082316<\/a>.<\/li>\n<li><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329-0501(22)00153-X\">Burr A, Erickson P, Imbriani-Bento R, Sharma K, <strong>Roth C<\/strong>, Parekkadan B. Allometric-like scaling of AAV gene therapy for systemic protein delivery. <em>Mol. Ther. Methods Clin. Dev.<\/em>, 2022; 27:368-379; doi:10.1016\/j.omtm.2022.10.011<\/a>.<\/li>\n<li><a href=\"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-020-07604-8\">Kantamneni H, Barkund SR, Donzanti MJ, Martin D, Zhao X, He S, Riman RE, Tan M-C, Pierce MC, <strong>Roth CM<\/strong>, Ganapathy V, Moghe PV. Shortwave infrared emitting multicolored nanoprobes for biomarker-specific\u00a0cancer\u00a0imaging in vivo. <em>BMC Cancer<\/em>, 2020; article 1082; doi: 10.1186\/s12885-020-07604-8<\/a>.<\/li>\n<li><a href=\"https:\/\/cdrjournal.com\/article\/view\/3373\">Nusblat LM, Tanna S, <strong>Roth CM<\/strong>, Gene silencing of HIF-2alpha disrupts glioblastoma stem cell phenotype. <em>Cancer Drug Resist.<\/em>, 2020; 3:199-208; doi: 10.20517\/cdr.2019.96<\/a>.<\/li>\n<li>Higgins LM, Ganapathy V, Kantamneni H, Zhao X, Sheng Y, Tan M-C, <strong>Roth CM<\/strong>, Riman RE, Moghe PV, Pierce MC. Multi-scale optical imaging of rare-earth-doped nanocomposites in a small animal model. <em>J. <\/em><em> Biomed. Opt.<\/em>, 2018; 23:030505; doi:10.1117\/1.JBO.23.3.030505.<\/li>\n<li>Kantamneni H, Zevon M, Donzanti MJ, Zhao X, Sheng Y, Barkund SR, McCabe LH, Banach-Petrosky W, Higgins LM, Ganesan S, Riman RE, <strong>Roth CM<\/strong>, Tan M-C, Pierce MC, Ganapathy V, Moghe PV. Surveillance nanotechnology for multi-organ cancer metastases. <em>Nature Biomed. Engr.<\/em>, 2017; 1:993-1003; doi:10.1038\/s41551-017-0167-9.<\/li>\n<li>Nusblat LM, Carroll MJ, <strong>Roth CM<\/strong>, Cross talk between M2 macrophages and glioma stem cells. <em>Cell Oncol.<\/em>, 2017; 40:471-482; DOI 10.1007\/s13402-017-0337-5.<\/li>\n<li>Gu L, Wang N, Nusblat LM, Soskind R, <strong>Roth CM<\/strong>, Uhrich KE. pH-responsive amphiphilic macromolecular carrier for doxorubicin delivery. <em>J. <\/em><em> Bioactive Compatible Polymers<\/em>, 2017; 32:3-16; doi:\u00a010.1177\/0883911516643219.<\/li>\n<li>Higgins LM, Zevon M, Ganapathy V, Sheng Y, Tan MC, Riman RE, <strong>Roth CM<\/strong>, Moghe PV, Pierce MC. Line-scanning confocal microscopy for high-resolution imaging of rare-earth-based upconverting contrast agents. <em>J. <\/em><em> Biomed. Opt.<\/em>, 2015; 20:110506; doi:10.1117\/1.JBO.20.11.110506.<\/li>\n<li>Ganapathy V, Moghe PV,<strong> Roth CM<\/strong>. Targeting tumor metastases: drug delivery mechanisms and challenges. <em>J. Control. Rel.<\/em>, 2015; 219:215-223; PMCID: PMC4745901.<\/li>\n<li>Zevon M, Ganapathy V, Kantamneni H, Mingozzi M, Kim P, Adler D, Pierce MC, Riman RE, <strong>Roth CM<\/strong>, Moghe PV. CXCR4 targeted short wave infrared (SWIR) emitting nanoprobes for enhanced deep tissue imaging and micrometastatic cancer lesion detection. <em>Small<\/em>, 2015; 11:6347-6357; PMCID: PMC4763715.<\/li>\n<li>Shreiber DI, Moghe PV, <strong>Roth CM<\/strong>. Multidisciplinary &#8220;Boot Camp&#8221; Training in Cellular Bioengineering to Accelerate Research Immersion for REU Participants. <em>Adv. Eng. Educ.<\/em>, 2015; 4(4):1-15; http:\/\/advances.asee.org\/wp-content\/uploads\/vol04\/issue04\/Papers\/AEE-16-Shreiber.pdf.<\/li>\n<li>Peddada LY, Garbuzenko OB, Devore DI, Minko T, <strong>Roth CM<\/strong>. Delivery of antisense oligonucleotides using poly(alkylene oxide)-poly(propylacrylic acid) graft copolymers in conjunction with cationic liposomes.\u00a0 <em>J. <\/em><em> Control. Rel.<\/em>, 2014; 194C:103-112; doi: 10.1016\/j.jconrel.2014.08.023; PMCID: PMC4573985.<\/li>\n<li>Gu L, Nusblat LM, Tishbi N, Noble SC, Pinson CM, Mintzer E, <strong>Roth CM<\/strong>, Uhrich KE. Cationic amphiphilic macromolecule (CAM)-lipid complexes for efficient siRNA delivery. <em>J. Control. Rel.<\/em>, 2014; 184:28-35; doi: 10.1016\/j.jconrel.2014.04.005; PMCID: PMC4090228.<\/li>\n<li>Naczynski DJ, Tan MC, Zevon M, Wall B, Kohl J, Kulesa A, Chen S, <strong>Roth CM<\/strong>, Riman RE, Moghe PV. Rare-earth doped nanoparticles as bioactive probes for shortwave infrared in vivo imaging. <em>Nature Commun.<\/em>, 2013; 4:2199; PMCID: PMC3736359.<\/li>\n<li>Cui M, Naczynski DJ, Zevon M, Poventud-Fuentes I, Chen S, <strong>Roth CM<\/strong>, Moghe PV. Multifunctional albumin nanoparticles as combination drug carriers for intra-tumoral chemotherapy. <em>Adv. Healthc. Mater.<\/em>, 2013; 2:2036-2045; doi: 10.1002\/adhm.201200467.<\/li>\n<li>Mishra S, Vaughn AD, Devore DI, <strong>Roth CM<\/strong>. Delivery of sirna silencing Runx2 using a multifunctional polymer-lipid nanoparticle inhibits osteogenesis in a cell culture model of heterotopic ossification. <em>Integr. Biol.<\/em>, 2012; 4:1498-1507; PMC4534437.<\/li>\n<li>Mishra S, Peddada LY, Devore DI, <strong>Roth CM<\/strong>. Poly(alkylene oxide) copolymers for nucleic acid delivery. <em>Acc. Chem. Res.<\/em>, 2012; 45:1057-1066; PMCID: PMC3361000.<\/li>\n<li>Waite CL, <strong>Roth CM<\/strong>. Nanoscale drug delivery systems for enhanced penetration into tumors: Current progress and opportunities. <em>Annu. Rev. Biomed Eng.<\/em>, 2012; 40:21-41; PMCID:PMC3639314.<\/li>\n<li>Waite CL, <strong>Roth CM<\/strong>. Binding and transport of PAMAM-RGD in a tumor spheroid model: The effect of RGD targeting ligand density. <em>Biotechnol. <\/em><em> Bioeng.<\/em>, 2011; PMCID: PMC3193538.<\/li>\n<li>Sparks SM, Waite CL, Harmon AM, Nusblat LM, <strong>Roth CM<\/strong>, Uhrich KE. Efficient intracellular siRNA delivery by ethyleneimine-modified nanoscale amphiphilic macromolecules. <em>Macromol.\u00a0Biosci.<\/em>, 2011; 11:1192-1200; PMCID: PMC3549469.<\/li>\n<li>Hamed SS, <strong>Roth CM<\/strong>. Mathematical modeling to distinguish cell cycle arrest from cell killing in chemotherapeutic concentration response curves.\u00a0 <em>J. <\/em><em> Pharmacokin. Pharmacodyn.<\/em>, 2011; 38:385-403; doi: 10.1007\/s10928-011-9199-z.<\/li>\n<li>Yang H, <strong>Roth CM<\/strong>, Ierapetritou MG. Analysis of amino acid supplementation effects on hepatocyte cultures using flux balance analysis.\u00a0 <em>OMICS<\/em>, 2011; 15:449-460; doi:10.1089\/omi.2010.0070.<\/li>\n<li>Yang H, Ierapetritou MG, <strong>Roth CM<\/strong>. Effects of amino acid transport limitations on cultured hepatocytes.\u00a0 <em>Biophys. <\/em><em> Chem.<\/em>, 2010; 152:89-98; http:\/\/dx.doi.org\/10.1016\/j.bpc.2010.08.004.<\/li>\n<li>Iyer VV, Ovacik MA, Androulakis IP, <strong>Roth CM<\/strong>, Ierapetritou MG. Transcriptional and metabolic flux profiling of triadimefon effects on cultured hepatocytes. <em>Toxicol. Appl. Pharmacol.<\/em>, 2010; 248:165-177; http:\/\/dx.doi.org\/10.1016\/j.taap.2010.07.015.<\/li>\n<li>Iyer VV, Yang H, Ierapetritou MG, <strong>Roth CM<\/strong>. Effects of glucose and insulin on HepG2-C3A cell metabolism.\u00a0 <em>Biotechnol. <\/em><em> Bioeng.<\/em>, 2010; 107:347-356; DOI: 10.1002\/bit.22799.\u00a0 <strong>Selected for Spotlight feature<\/strong>.<\/li>\n<li>Naczynski DJ, Andelman T, Pal D, Chen S, Riman RE, <strong>Roth CM<\/strong>, Moghe PV. Albumin nanoshell encapsulation of near infrared excitable rare earth nanoparticles enhances biocompatibility and enables targeted cell imaging.\u00a0 <em>Small<\/em>, 2010; 6;1631-40; DOI: 10.1002\/smll.200902403.\u00a0 <strong>Selected for issue cover<\/strong>.<\/li>\n<li>Waite CL, <strong>Roth CM<\/strong>. PAMAM-RGD conjugates enhance delivery of siRNA through a multicellular spheroid model of malignant glioma.\u00a0 <em>Bioconjugate <\/em><em> Chem.<\/em>, 2009; 20:1908-1916; PMCID:PMC3047462.<\/li>\n<li>Peddada LY, Harris NK, Devore DI, <strong>Roth CM<\/strong>. Novel graft copolymers enhance in vitro delivery of antisense oligonucleotides in the presence of serum.\u00a0 <em>J. Control. Rel.<\/em>, 2009; 140:134-140; PMCID: PMC2783907.<\/li>\n<li>Yang H, <strong>Roth CM<\/strong>, Ierapetritou MG. A rational design approach for amino acid supplementation in hepatocyte culture.\u00a0 <em>Biotechnol. <\/em><em> Bioeng.<\/em>, 2009; 103:1176-1191.<\/li>\n<li>Waite CL, Sparks SM, Uhrich KE, <strong>Roth CM<\/strong>. Acetylation of dendrimers for cellular delivery of siRNA.\u00a0 <em>BMC Biotechnol.<\/em>, 2009; 9:38; PMCID: PMC 2679008.<\/li>\n<li>Ierapetritou MI, Georgopoulos PG, <strong>Roth CM<\/strong>, Androulakis IP. Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research.\u00a0 <em>Clin. Transl. Sci.<\/em>, 2009; 2:228-237; PMCID: PMC3068531.<\/li>\n<li><strong>Roth CM<\/strong>. Quantitative measurements and rational materials design for intracellular delivery of oligonucleotides.\u00a0 <em>Biotechnol. <\/em><em> Prog.<\/em>, 2008; 24:23-28.<\/li>\n<li>Burley MR, <strong>Roth CM.<\/strong> Effects of retinoic acid on the proliferation and differentiation of HepG2 cells.\u00a0 <em>Open Biotechnol. J.<\/em>; 2007; 1:47-51.<\/li>\n<li>Sundaram S, Lee LK, <strong>Roth CM<\/strong>. Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity.\u00a0 <em>Nucleic Acids Res.<\/em>, 2007; 35:4396-4408; PMCID: PMC1935005.<\/li>\n<li>Moghe PV and <strong>Roth CM<\/strong>. Multidisciplinary graduate curriculum on integrative biointerfacial engineering. <em>Chem. Eng. Educ.<\/em>, 2006; 40:251-258.<\/li>\n<li>Yang H, Yarmush ML, <strong>Roth CM<\/strong>, Ierapetritou MG. Minimal reaction sets and metabolic pathways for cultured hepatocytes. <em>Comp. Chem. Eng.<\/em>, 2006; 103:1176-1191.<\/li>\n<li>Lee LK, Dunham BM, Li Z, <strong>Roth CM<\/strong>. Cellular dynamics of antisense oligonucleotides and short interfering RNAs.\u00a0 <em> N.Y. Acad. Sci.<\/em>, 2006; 1082:47-51.<\/li>\n<li>Lee LK, Williams CL, Devore D, <strong>Roth CM<\/strong>. Poly(propylacrylic acid) enhances cationic lipid mediated delivery of antisense oligonucleotides.\u00a0 <em>Biomacromolecules<\/em>, 2006; 7:1502-1508; PMCID: PMC2525803.<\/li>\n<li>Katz JM, <strong>Roth CM<\/strong>, Dunn MG. Factors that influence transgene expression and cell viability on DNA-PEI seeded collagen films. <em>Tissue Eng.<\/em>, 2005; 11:1398-1406.<\/li>\n<li>Gevertz JL, Dunn SM, <strong>Roth CM<\/strong>. Mathematical model of real-time PCR kinetics. <em>Biotech.\u00a0Bioeng.<\/em>, 2005; 92:346-355.<\/li>\n<li>Sundaram S, Viriyayuthakorn S, <strong>Roth CM<\/strong>. Oligonucleotide structure influences the interaction between cationic polymers and oligonucleotides. <em>Biomacromolecules<\/em>, 2005; 6:2961-2968; PMCID: PMC2519154.<\/li>\n<li><strong>Roth CM.<\/strong> Molecular and cellular barriers limiting the effectiveness of antisense oligonucleotides.\u00a0 <em> J.<\/em>, 2005, 89:2286-2295; PMCID: PMC1366730.<\/li>\n<li>Jayaraman A, Yarmush ML, <strong>Roth CM<\/strong>. Evaluation of an in vitro model of hepatic inflammatory response by gene expression profiling.\u00a0 <em>Tissue Eng.<\/em>, 2005; 11:50-63.<\/li>\n<li><strong>Roth CM<\/strong>, Sundaram S. Engineering synthetic vectors for improved DNA delivery: Insights from intracellular pathways.\u00a0 <em> Rev. Biomed. Engr.<\/em>, 2004; 6:397-426.<\/li>\n<li>Lee LK and <strong>Roth CM<\/strong>. Antisense technology in molecular and cellular bioengineering.\u00a0 <em> Opin. Biotechnol.<\/em>, 2003; 14:505-511.<\/li>\n<li><strong>Roth CM<\/strong>. Quantifying gene expression. <em>Curr. Issues Mol. Biol.<\/em>, 2002; 4:93-100.<\/li>\n<li>Jayaraman A, Yarmush ML, <strong>Roth CM<\/strong>. Molecular bioengineering. <em>Ind. Eng. Chem. Res.<\/em>, 2002; 41:441-455.<\/li>\n<li>Walton SP, Stephanopoulos GN, Yarmush ML, <strong>Roth CM<\/strong>. Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. <em>Biophys. J.<\/em>, 2002; 82:366-377; PMCID: PMC1302476.<\/li>\n<li>Jayaraman A, Walton SP, Yarmush ML, <strong>Roth CM<\/strong>. Rational selection and quantitative evaluation of antisense oligonucleotides. <em>Biochim. Biophys. Acta<\/em>, 2001; 1520:105-114.<\/li>\n<li><strong>Roth CM<\/strong>, Kohen RL, Walton SP, Yarmush ML. Coupling of inflammatory cytokine signaling pathways probed by measurements of extracellular acidification rate. <em>Biophys. <\/em><em> Chem.<\/em>, 2001; 89:1-12.<\/li>\n<li>Jayaraman A, Yarmush ML, <strong>Roth CM<\/strong>. Dynamics of gene expression in rat hepatocytes under stress. <em>Metabolic Eng.<\/em>, 2000; 2:239-251.<\/li>\n<li>Roy P, <strong>Roth CM<\/strong>, Margolies MN, Yarmush ML. Aromatic residues mediate the pressure-induced association of digoxigenin and antibody 26-10. <em>Biophys. Chem.<\/em>, 1999; 83:171-177.<\/li>\n<li>Roy P, <strong>Roth CM<\/strong>, Margolies MN, Yarmush ML. Effect of pressure on antigen-antibody complexes: modulation by ionic strength and temperature. <em>Mol. Immunol.<\/em>, 1999; 36:1149-1158.<\/li>\n<li><strong>Roth CM<\/strong>, Yarmush ML. Nucleic acid biotechnology.\u00a0 <em>Annu. Rev. Biomed. Engr.<\/em>, 1999, 1:265-297.<\/li>\n<li>Andreadis ST, <strong>Roth CM<\/strong>, Le Doux, JM, Morgan, JR, Yarmush, ML. Large-scale processing of recombinant retroviruses for gene therapy. <em>Biotechnol. <\/em><em> Prog.<\/em>, 1999, 15:1-11.<\/li>\n<li>Walton SP, Stephanopoulos GN, Yarmush ML, <strong>Roth CM<\/strong>. Prediction of antisense oligonucleotide binding affinity to a structured RNA target. <em>Biotechnol. <\/em><em> Bioeng.<\/em>, 1999; 65:1-9.<\/li>\n<li>Sundaram S, <strong>Roth CM<\/strong>, Yarmush ML. Pressure-induced dissociation of antigen-antibody complexes. <em>Biotechnol. <\/em><em>Prog.<\/em>, 1998; 14:773-781.<\/li>\n<li><strong>Roth CM<\/strong>, Sader JE, Lenhoff AM. Electrostatic contribution to the energy and entropy of protein adsorption. <em>J. Colloid Interface Sci.<\/em>, 1998; 203:218-221.<\/li>\n<li>Rajur SB, <strong>Roth CM<\/strong>, Morgan JR, Yarmush ML. Covalent protein-oligonucleotide conjugates for efficient delivery of antisense molecules. <em>Bioconjugate Chem.<\/em>, 1997; 8:935-940.<\/li>\n<li><strong>Roth CM<\/strong>, Reiken SR, Le Doux JM, Rajur SB, Lu X-M, Morgan JR, Yarmush ML. Targeted antisense modulation of inflammatory cytokine receptors. <em>Biotechnol. Bioeng.<\/em>, 1997; 55:72-81.<\/li>\n<li><strong>Roth CM<\/strong>, Lenhoff AM. Improved parametric representation of water dielectric data for Lifshitz theory calculations. <em>J. <\/em><em> Colloid Interface Sci.<\/em>, 1996; 179:637-639.<\/li>\n<li><strong>Roth CM<\/strong>, Unger KK, Lenhoff AM. A mechanistic model for retention in ion exchange chromatography. <em>J. Chromatogr.<\/em>, 1996; 726:45-56.<\/li>\n<li><strong>Roth CM<\/strong>, Neal BL, Lenhoff AM. Van der Waals interactions involving proteins. <em>Biophys.\u00a0J.<\/em>, 1996; 70:977-987; PMCID PMC1224998.<\/li>\n<li><strong>Roth CM<\/strong>, Lenhoff AM. Electrostatic and van der Waals contributions to protein adsorption:\u00a0 comparison of theory with experiment. <em>Langmuir<\/em>, 1995; 11:3500-3509.<\/li>\n<li><strong>Roth CM<\/strong>, Lenhoff AM. Electrostatic and van der Waals contributions to protein adsorption:\u00a0 computation of equilibrium constants. <em>Langmuir<\/em>, 1993; 9:962-972.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Varela-Soler Y, Xu W, Lima MRN, McDonald J, Jagpal SK, Kirn TJ, Hussain S, Devore DI, Roth CM. Antimicrobial loaded graft-copolymer nanoparticles for treatment of Pseudomonas aeruginosa infections. bioRxiv, 2025; &hellip; <a href=\"https:\/\/sites.rutgers.edu\/charles-roth\/publications\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-170","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Publications - Charles Roth<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/charles-roth\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Charles Roth\" \/>\n<meta property=\"og:description\" content=\"Varela-Soler Y, Xu W, Lima MRN, McDonald J, Jagpal SK, Kirn TJ, Hussain S, Devore DI, Roth CM. 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