{"id":394,"date":"2019-12-09T19:32:01","date_gmt":"2019-12-09T19:32:01","guid":{"rendered":"http:\/\/sites.rutgers.edu\/charles-roth\/?page_id=394"},"modified":"2025-08-22T20:45:30","modified_gmt":"2025-08-22T20:45:30","slug":"nanomaterials-for-antimicrobial-drug-delivery-to-wounds","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/charles-roth\/nanomaterials-for-antimicrobial-drug-delivery-to-wounds\/","title":{"rendered":"Nanomaterials for Antimicrobial Drug Delivery to Wounds"},"content":{"rendered":"

Infections that are able to penetrate soft tissues, such as those in combat wounds, burns, and implanted medical hardware, are particularly challenging to treat. The tissue microenvironment promotes biofilm formation and, following therapy, development of multidrug resistance (MDR). We aim to develop a multifunctional precision nanomedicine for the treatment of MDR biofilm infections in these applications. <\/em><\/strong>Our approach features polyanionic surfactants (PS) that self-assemble with cationic antimicrobial peptides and amine-functional (e.g. aminoglycoside) antibiotics to form nanocomplexes whose properties in solution can be tailored to be favorable for delivery. In addition to encapsulating and controlling the release kinetics of cationic drugs, the PS are designed to disrupt biofilms through surfactant interfacial interactions with the biofilm\u2019s extracellular polymeric substances (EPS). We have used these PS to encapsulate novel lipopeptide antibiotics and incorporated them into hydrogels with biocompatible biopolymers. These nanostructured gels exhibit effective topical antimicrobial activity in a porcine partial thickness infected wound model. We are also developing “nanospray” formulations that allow administration without direct contact, in order to lessen the high degree of pain associated with contact-based administration.<\/p>\n

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Polyelectroloyte surfactants are used to self-assemble and encapsulate antimicrobial peptides. We have done this for novel fusaracidin cyclic lipopeptide 2579-7 and shown that its activity against MRSA infection in a porcine wound model is improved by an order of magnitude.<\/strong><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Infections that are able to penetrate soft tissues, such as those in combat wounds, burns, and implanted medical hardware, are particularly challenging to treat. The tissue microenvironment promotes biofilm formation … Read More<\/a><\/p>\n","protected":false},"author":375,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-394","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nNanomaterials for Antimicrobial Drug Delivery to Wounds - Charles Roth<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/charles-roth\/nanomaterials-for-antimicrobial-drug-delivery-to-wounds\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanomaterials for Antimicrobial Drug Delivery to Wounds - Charles Roth\" \/>\n<meta property=\"og:description\" content=\"Infections that are able to penetrate soft tissues, such as those in combat wounds, burns, and implanted medical hardware, are particularly challenging to treat. 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