{"id":512,"date":"2024-09-24T16:55:44","date_gmt":"2024-09-24T16:55:44","guid":{"rendered":"https:\/\/sites.rutgers.edu\/christopher-shuck\/?p=512"},"modified":"2024-09-24T16:55:44","modified_gmt":"2024-09-24T16:55:44","slug":"all-mxene-electronic-tongue-for-neurotransmitters-detection","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/","title":{"rendered":"All-MXene electronic tongue for neurotransmitters detection"},"content":{"rendered":"<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0956566324005311\">New article published in Biosensors and Bioelectronics!\u00a0<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Neurotransmitters\u00a0(NTs) are molecules produced by neurons that act as the body&#8217;s chemical messengers. Their abnormal levels in the human system have been associated with many disorders and\u00a0neurodegenerative diseases, which makes the monitoring of NTs fundamentally important. Specifically for clinical analysis and understanding of\u00a0brain\u00a0behavior, simultaneous detection of NTs at low levels quickly and reliably is imperative for disease prevention and early diagnosis. However, the methods currently employed are usually invasive or inappropriate for multiple NTs detection. Herein, we developed a MXene-based impedimetric electronic tongue (e-tongue) for sensitive NT monitoring, using Nb<sub>2<\/sub>C, Nb<sub>4<\/sub>C<sub>3<\/sub>, Mo<sub>2<\/sub>C, and Mo<sub>2<\/sub>Ti<sub>2<\/sub>C<sub>3<\/sub>\u00a0MXenes as sensing units of the e-tongue, and\u00a0Principal Component Analysis\u00a0(PCA) as the data treatment method. The high specific\u00a0surface area, distinct electrical properties, and chemical stability of the MXenes gave rise to high sensitivity and good reproducibility of the sensor array toward NT detection. Specifically, the e-tongue detected and differentiated multiple NTs (acetylcholine, dopamine, glycine,\u00a0glutamate, histamine, and tyrosine) at concentrations as low as 1\u00a0nmol\u00a0L<sup>\u22121<\/sup>\u00a0and quantified NTs present in a mixture. Besides, analyses performed with interferents and actual samples confirmed the system&#8217;s potential to be used in clinical diagnostics. The results demonstrate that the MXene-based e-tongue is a suitable, rapid, and simple method for NT monitoring with high accuracy and sensitivity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New article published in Biosensors and Bioelectronics!\u00a0 &nbsp; Neurotransmitters\u00a0(NTs) are molecules produced by neurons that act as the body&#8217;s chemical messengers. Their abnormal levels in the human system have been &hellip; <a href=\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":3514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-512","post","type-post","status-publish","format-standard","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>All-MXene electronic tongue for neurotransmitters detection - Christopher Shuck Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"All-MXene electronic tongue for neurotransmitters detection - Christopher Shuck Lab\" \/>\n<meta property=\"og:description\" content=\"New article published in Biosensors and Bioelectronics!\u00a0 &nbsp; Neurotransmitters\u00a0(NTs) are molecules produced by neurons that act as the body&#8217;s chemical messengers. Their abnormal levels in the human system have been &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\" \/>\n<meta property=\"og:site_name\" content=\"Christopher Shuck Lab\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-24T16:55:44+00:00\" \/>\n<meta name=\"author\" content=\"Christopher E. Shuck\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Christopher E. Shuck\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\",\"url\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\",\"name\":\"All-MXene electronic tongue for neurotransmitters detection - Christopher Shuck Lab\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/#website\"},\"datePublished\":\"2024-09-24T16:55:44+00:00\",\"dateModified\":\"2024-09-24T16:55:44+00:00\",\"author\":{\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/#\/schema\/person\/48de8e0dab2e9b0f2dae353cf1304c40\"},\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/all-mxene-electronic-tongue-for-neurotransmitters-detection\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"All-MXene electronic tongue for neurotransmitters detection\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/\",\"name\":\"Christopher Shuck Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.rutgers.edu\/christopher-shuck\/#\/schema\/person\/48de8e0dab2e9b0f2dae353cf1304c40\",\"name\":\"Christopher E. 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