{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/david-zald\/?page_id=365"},"modified":"2024-11-22T15:39:41","modified_gmt":"2024-11-22T15:39:41","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/david-zald\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Interests<\/strong><\/h2>\n

NEURAL SUBSTRATES OF EMOTION AND MOTIVATION<\/strong><\/p>\n

Using functional MRI we can map the brain regions involved in emotion and motivation.\u00a0 Brain regions, such as the amygdala, play an integral role in emotional processing. We have attempted to reveal the situations in which the amygdala becomes more active and the impact of lesions on the amygdala.<\/p>\n

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NEUROCIRCUITRY AND FUNCTIONS OF THE ORBITOFRONTAL CORTEX<\/strong><\/p>\n

The orbitofrontal cortex lies at the based of the frontal lobe and plays a critical role in personality and psychopathology. I was not a neuroscience major in college. In fact I studied music, film-video and near-eastern studies. Trying to understand what this brain region does was my entry point into the world of neuroscience. Understanding what happens to people when this brain region is damaged and how its functions contribute to psychopathology remain key elements of my lab’s research.<\/p>\n

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BEHAVIORAL AND PERSONALITY CORRELATES OF INDIVIDUAL DIFFERENCES IN THE DOPAMINE SYSTEM<\/strong><\/p>\n

Multiple aspects of the dopamine system can be measured in humans with Positron Emission Tompograph (PET) imaging, including levels of D2 receptors, dopamine transporters, dopamine synthesis capacity and dopamine release in response to drugs such as amphetamine.\u00a0 We have found that aspects of the dopamine system that regulate dopamine, including autoreceptors and dopamine transporters are related to externalizing traits including impulsivity, novelty-seeking, and antisociality.<\/p>\n

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THE IMPACT OF AGING ON THE DOPAMINE SYSTEM<\/strong><\/p>\n

D2 dopamine receptors decline steadily with age.\u00a0 Working wit Greg Samanez-Larkin and colleagues at Duke University, we have attempted to understand how these declines impact behavior.<\/p>\n

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TEMPTATIONS, IMPULSIVE AND COMPULSIVE BEHAVIOR<\/p>\n

Impulsivity and compulsive behaviors are common problems across different types of psychopathology and even arises in response to certain dopaminergic medicines in Parkinson’s Disease.\u00a0 We have worked to define the neurobiological correlates of these problems. Current work also focuses on individual differences in the ability to resist temptations, and whether poor temptation resistance efficacy represents a common featuresof externalzing disorder. This work also examines the impact of genes and environment on temptation resistance efficacy.<\/p>\n

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TRANSDIAGNOSTIC AND NONSPECIFIC DIMENSIONS OF PSYCHOPATHOLOGY<\/p>\n

Although psychiatric research and treatment often focuses on specific categorically-defined disorders, the pattern of correlations across symptoms make clear that many mental health problems cut across disorders.\u00a0 Indeed, there is a complex dimensional structure of psychopathology.\u00a0 We have attempted to elucidate the structure of psychopathology, particularly as it relates to a nonspecific general factor of psychopathology.\u00a0 Working with Benjamin Lahey, we provided early evidence for such a nonspecific factor, and have continue to worked to examine whether their are neural correlates of psychopathology that are more related to this general factor as opposed to being related to a specific disorder or narrower dimension of psychopathology.<\/p>\n

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THE INTERACTION OF EMOTION AND ATTENTION<\/p>\n

Emotional stimuli capture our attention.\u00a0 We have attempted to explore precisely how this happens, and where in the brain this prioritization of emotional stimuli occurs.<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

Interests NEURAL SUBSTRATES OF EMOTION AND MOTIVATION Using functional MRI we can map the brain regions involved in emotion and motivation.\u00a0 Brain regions, such as the amygdala, play an integral … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResearch - David Zald<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/david-zald\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - David Zald\" \/>\n<meta property=\"og:description\" content=\"Interests NEURAL SUBSTRATES OF EMOTION AND MOTIVATION Using functional MRI we can map the brain regions involved in emotion and motivation.\u00a0 Brain regions, such as the amygdala, play an integral … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/david-zald\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"David Zald\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-22T15:39:41+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/david-zald\/wp-content\/uploads\/sites\/537\/2020\/09\/Screen-Shot-2020-09-03-at-12.05.15-PM-300x181.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/david-zald\/research\/\",\"url\":\"https:\/\/sites.rutgers.edu\/david-zald\/research\/\",\"name\":\"Research - 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