{"id":447,"date":"2020-09-05T21:43:08","date_gmt":"2020-09-05T21:43:08","guid":{"rendered":"http:\/\/sites.rutgers.edu\/friedman-lab\/?page_id=447"},"modified":"2024-03-13T21:18:52","modified_gmt":"2024-03-13T21:18:52","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects\/","title":{"rendered":"Research Projects"},"content":{"rendered":"

p75NTR in the Developing Cerebellum<\/strong><\/p>\n

The p75 neurotrophin receptor (p75NTR) is highly expressed in proliferating progenitor cells in the developing brain.\u00a0 In the cerebellum, p75NTR (green) is present in all proliferating (red) granule cell progenitors.<\/p>\n

\"\"<\/p>\n

We have demonstrated that this receptor regulates the duration of the cell cycle of these progenitors.\u00a0 We continue to study the mechanisms by which this receptor regulates the cell cycle, and the consequences of its absence for brain development and function.<\/p>\n

See our recent papers on this topic:<\/p>\n

Zanin, J.P., J. Verpeut, Li, Y., Shiflett, M.W., S.-S. Wang, Santhakumar, V., and W.J. Friedman,<\/strong> The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors, J. Neurosci<\/em>. 39 (46) 9119-9129; DOI: https:\/\/doi.org\/10.1523\/JNEUROSCI.0990-19.2019<\/a>, 2019, Cover Article<\/strong><\/p>\n

Zanin, J.P. and W.J. Friedman<\/strong>, p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation, eLife, https:\/\/doi.org\/10.7554\/eLife.79934<\/a>, 2022<\/p>\n

Zanin, J.P., M.A. Pandya, D. Espinoza, W.J. Friedman, <\/strong>and M.W. Shiflett, Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice, Frontiers in Molecular Neuroscience, Volume 16, https:\/\/doi.org\/10.3389\/fnmol.2023.1147597<\/a>, 2023<\/p>\n","protected":false},"excerpt":{"rendered":"

p75NTR in the Developing Cerebellum The p75 neurotrophin receptor (p75NTR) is highly expressed in proliferating progenitor cells in the developing brain.\u00a0 In the cerebellum, p75NTR (green) is present in all … Read More<\/a><\/p>\n","protected":false},"author":1213,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-447","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResearch Projects - Friedman Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Projects - Friedman Lab\" \/>\n<meta property=\"og:description\" content=\"p75NTR in the Developing Cerebellum The p75 neurotrophin receptor (p75NTR) is highly expressed in proliferating progenitor cells in the developing brain.\u00a0 In the cerebellum, p75NTR (green) is present in all … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects\/\" \/>\n<meta property=\"og:site_name\" content=\"Friedman Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-13T21:18:52+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/friedman-lab\/wp-content\/uploads\/sites\/532\/2020\/08\/p75cblm-e1598802982368-300x116.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects\/\",\"url\":\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects\/\",\"name\":\"Research Projects - 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