{"id":484,"date":"2020-09-05T21:43:52","date_gmt":"2020-09-05T21:43:52","guid":{"rendered":"http:\/\/sites.rutgers.edu\/friedman-lab\/?page_id=484"},"modified":"2024-03-13T21:14:41","modified_gmt":"2024-03-13T21:14:41","slug":"research-projects-cont","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects-cont\/","title":{"rendered":"Research Projects, cont."},"content":{"rendered":"<p><strong>Neurotrophins and neurodegeneration<\/strong><\/p>\n<p>The p75 neurotrophin receptor is induced in neurons after brain injury, and mediates neuronal death.\u00a0 We have shown that blocking activation of p75NTR, either by preventing upregulation of the receptor or blocking the ligands with antibodies, under injury conditions provides neuroprotection.<\/p>\n<p>See our recent papers on this:<\/p>\n<p>Montroull, L.E., D. Rothbard, H.D. Kanal, V. D\u2019Mello, V. Dodson, C.M. Troy, J.P. Zanin, S.W. Levison, and W.J. Friedman, Pro-Neurotrophins induce apoptotic neuronal death after controlled cortical impact injury in adult mice, <em>ASN Neuro<\/em>, 12:1-13; <a href=\"https:\/\/doi.org\/10.1177%2F1759091420930865\">https:\/\/doi.org\/10.1177\/1759091420930865<\/a>, 2020<\/p>\n<p>Dasgupta, S., L. Montroull, M. Pandya, W. Wang, Z. Wu, and <strong>W.J. Friedman<\/strong>, Cortical brain injury causes retrograde degeneration of afferent basal forebrain cholinergic neurons via p75NTR, eNeuro, 10(8) ENEURO.0067-23.2023 1\u201314 <a href=\"https:\/\/www.eneuro.org\/content\/early\/2023\/08\/07\/ENEURO.0067-23.2023\">https:\/\/www.eneuro.org\/content\/early\/2023\/08\/07\/ENEURO.0067-23.2023<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurotrophins and neurodegeneration The p75 neurotrophin receptor is induced in neurons after brain injury, and mediates neuronal death.\u00a0 We have shown that blocking activation of p75NTR, either by preventing upregulation &hellip; <a href=\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects-cont\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":1213,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-484","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Projects, cont. - Friedman Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/friedman-lab\/research-projects-cont\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Projects, cont. - Friedman Lab\" \/>\n<meta property=\"og:description\" content=\"Neurotrophins and neurodegeneration The p75 neurotrophin receptor is induced in neurons after brain injury, and mediates neuronal death.\u00a0 We have shown that blocking activation of p75NTR, either by preventing upregulation &hellip; 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