{"id":681,"date":"2023-04-24T14:59:27","date_gmt":"2023-04-24T14:59:27","guid":{"rendered":"https:\/\/sites.rutgers.edu\/glytsou-lab\/?p=681"},"modified":"2023-04-24T15:05:28","modified_gmt":"2023-04-24T15:05:28","slug":"new-study-published","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/","title":{"rendered":"New study published"},"content":{"rendered":"<p><strong><a href=\"https:\/\/aacrjournals.org\/cancerdiscovery\/article-abstract\/doi\/10.1158\/2159-8290.CD-22-0601\" target=\"_blank\" rel=\"noopener\">Hot off the press!<\/a><\/strong><\/p>\n<p>Our brand new study published today in Cancer Discovery.<\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">Now in <a href=\"https:\/\/twitter.com\/CD_AACR?ref_src=twsrc%5Etfw\">@CD_AACR<\/a>: <a href=\"https:\/\/twitter.com\/hashtag\/Mitophagy?src=hash&amp;ref_src=twsrc%5Etfw\">#Mitophagy<\/a> Promotes Resistance to BH3 Mimetics in Acute Myeloid <a href=\"https:\/\/twitter.com\/hashtag\/Leukemia?src=hash&amp;ref_src=twsrc%5Etfw\">#Leukemia<\/a> &#8211; <a href=\"https:\/\/twitter.com\/glytsou?ref_src=twsrc%5Etfw\">@glytsou<\/a> <a href=\"https:\/\/twitter.com\/xufeng_chen?ref_src=twsrc%5Etfw\">@xufeng_chen<\/a> Emmanouil Zacharioudakis <a href=\"https:\/\/twitter.com\/ProfGavathiotis?ref_src=twsrc%5Etfw\">@ProfGavathiotis<\/a> <a href=\"https:\/\/twitter.com\/iannisaifantis1?ref_src=twsrc%5Etfw\">@iannisaifantis1<\/a> et al. <a href=\"https:\/\/twitter.com\/RutgersCancer?ref_src=twsrc%5Etfw\">@RutgersCancer<\/a> <a href=\"https:\/\/twitter.com\/ae_cancercenter?ref_src=twsrc%5Etfw\">@ae_cancercenter<\/a> <a href=\"https:\/\/twitter.com\/EinsteinMed?ref_src=twsrc%5Etfw\">@EinsteinMed<\/a> <a href=\"https:\/\/twitter.com\/Perlmutter_CC?ref_src=twsrc%5Etfw\">@Perlmutter_CC<\/a> <a href=\"https:\/\/twitter.com\/NYUGSOM_Path?ref_src=twsrc%5Etfw\">@NYUGSOM_Path<\/a> <a href=\"https:\/\/t.co\/Ehq9QtqAMy\">https:\/\/t.co\/Ehq9QtqAMy<\/a> <a href=\"https:\/\/t.co\/hbZmpNh7UE\">pic.twitter.com\/hbZmpNh7UE<\/a><\/p>\n<p>&mdash; Elizabeth McKenna (@ElizSMcKenna) <a href=\"https:\/\/twitter.com\/ElizSMcKenna\/status\/1650505926003048450?ref_src=twsrc%5Etfw\">April 24, 2023<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p>We asked, \u201cWhich are the common mechanisms of resistance to various BH3-mimetics-based therapies that are used in clinics or under clinical investigation in AML?\u201d. Applying CRISPR\/Cas9 screens and establishing preclinical drug-resistant AML models, we showed that mitophagy promotes resistance to BH3-mimetic drugs in AML. Targeting key regulators of mitochondrial clearance can reverse drug resistance.<\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">Check out our brand new study <a href=\"https:\/\/twitter.com\/CD_AACR?ref_src=twsrc%5Etfw\">@CD_AACR<\/a>.  We asked, \u201cWhich are the common mechanisms of resistance to various BH3-mimetics-based therapies that are used in clinics or under clinical investigation in Acute Myeloid Leukemia?\u201d <a href=\"https:\/\/t.co\/hvT9fnkm2d\">https:\/\/t.co\/hvT9fnkm2d<\/a><\/p>\n<p>&mdash; Christina Glytsou (@glytsou) <a href=\"https:\/\/twitter.com\/glytsou\/status\/1650494843582382080?ref_src=twsrc%5Etfw\">April 24, 2023<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hot off the press! Our brand new study published today in Cancer Discovery. Now in @CD_AACR: #Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid #Leukemia &#8211; @glytsou @xufeng_chen Emmanouil &hellip; <a href=\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":2892,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[],"class_list":["post-681","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New study published - Glytsou Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New study published - Glytsou Lab\" \/>\n<meta property=\"og:description\" content=\"Hot off the press! Our brand new study published today in Cancer Discovery. Now in @CD_AACR: #Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid #Leukemia &#8211; @glytsou @xufeng_chen Emmanouil &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\" \/>\n<meta property=\"og:site_name\" content=\"Glytsou Lab\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-24T14:59:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-24T15:05:28+00:00\" \/>\n<meta name=\"author\" content=\"Christina Glytsou\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Christina Glytsou\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\",\"url\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\",\"name\":\"New study published - Glytsou Lab\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/#website\"},\"datePublished\":\"2023-04-24T14:59:27+00:00\",\"dateModified\":\"2023-04-24T15:05:28+00:00\",\"author\":{\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/221550038d09c2c515d9a4452cc1d438\"},\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New study published\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/\",\"name\":\"Glytsou Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/221550038d09c2c515d9a4452cc1d438\",\"name\":\"Christina Glytsou\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/363c2c2baf205017ab2f9858ea4944ac?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/363c2c2baf205017ab2f9858ea4944ac?s=96&d=mm&r=g\",\"caption\":\"Christina Glytsou\"},\"url\":\"https:\/\/sites.rutgers.edu\/glytsou-lab\/author\/cg1006\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New study published - Glytsou Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/","og_locale":"en_US","og_type":"article","og_title":"New study published - Glytsou Lab","og_description":"Hot off the press! Our brand new study published today in Cancer Discovery. Now in @CD_AACR: #Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid #Leukemia &#8211; @glytsou @xufeng_chen Emmanouil &hellip; Read More","og_url":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/","og_site_name":"Glytsou Lab","article_published_time":"2023-04-24T14:59:27+00:00","article_modified_time":"2023-04-24T15:05:28+00:00","author":"Christina Glytsou","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Christina Glytsou"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/","url":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/","name":"New study published - Glytsou Lab","isPartOf":{"@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/#website"},"datePublished":"2023-04-24T14:59:27+00:00","dateModified":"2023-04-24T15:05:28+00:00","author":{"@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/221550038d09c2c515d9a4452cc1d438"},"breadcrumb":{"@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/new-study-published\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.rutgers.edu\/glytsou-lab\/"},{"@type":"ListItem","position":2,"name":"New study published"}]},{"@type":"WebSite","@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/#website","url":"https:\/\/sites.rutgers.edu\/glytsou-lab\/","name":"Glytsou Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.rutgers.edu\/glytsou-lab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/221550038d09c2c515d9a4452cc1d438","name":"Christina Glytsou","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/glytsou-lab\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/363c2c2baf205017ab2f9858ea4944ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/363c2c2baf205017ab2f9858ea4944ac?s=96&d=mm&r=g","caption":"Christina Glytsou"},"url":"https:\/\/sites.rutgers.edu\/glytsou-lab\/author\/cg1006\/"}]}},"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/posts\/681"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/users\/2892"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/comments?post=681"}],"version-history":[{"count":4,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/posts\/681\/revisions"}],"predecessor-version":[{"id":686,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/posts\/681\/revisions\/686"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/media?parent=681"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/categories?post=681"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/glytsou-lab\/wp-json\/wp\/v2\/tags?post=681"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}