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David Ribnicky PhD, Assistant Research Professor

I graduDavid Ribnickyated with honors in botany from the University of Michigan in 1989. In my doctoral thesis on “The Role of Auxin in Carrot Embryogenesis”, which was completed at the University of Maryland and at the USDA, I investigated basic mechanisms of plant totipotency.

I joined the laboratory of Ilya Raskin in 1996, focusing on the biosynthesis of salicylic acid and how some of its potential precursors may also be involved in the process of systemic acquired resistance (SAR) in plants. Previous work in our lab showed that an important volatile metabolite of salicylic acid, methyl salicylate, acts as an airborne signal between plants (Shulaev et al., 1997). I showed that benzaldehyde is also produced and released as a volatile organic compound from tobacco and measured endogenous concentrations of benzaldehyde by GC-MS. Benzaldehyde treatment leads to increased concentrations of salicylic acid and PR protein mRNA and promotes increased resistance to TMV inoculation. Even though a great deal of work has been directed at the biosynthesis of salicylic acid, the conversion of cinnamic acid to benzoic acid has not yet been elucidated. Through stable isotope labeling experiments, I have shown that benzaldehyde is not the intermediate between cinnamic and benzoic acid and that alternate pathways of salicylic acid are likely to be active (Ribnicky et al, 1997).

Currently I am a research associate and the principal investigator for the development of novel nutraceuticals from plants. This is a fascinating research area that has allowed me to combine my expertise in plant growth regulation and defense response with the production of natural products that impart significant health benefit. Many plants contain nutraceutical compounds and the concentrations of these important chemicals can differ dramatically between different species. As a botanist by training, I believe that these compounds are not present in plants by chance. Rather, they represent the chemical means that a plant must utilize in order to survive in a hostile environment from which it cannot escape. With some knowledge of such biochemical pathways, it is possible to determine which species contain the richest concentrations of such compounds and to take advantage of the innate defense mechanisms of plants to promote elevated production of desirable products.

My work has involved optimizing the production of various nutraceutical products using these basic approaches. In addition, I have developed the necessary methods for the precise quantification of these compounds as well as appropriate protocols for their efficient extraction. Using this approach, I have developed a natural analgesic with aspirin-like characteristics that can be taken on a daily basis for cardiovascular health. This extract can also provide protection to other plants from various pathogens, demonstrating the role of these compounds in nature.

I have also developed a rich source of phenyl ethyl isothiocyanate (PEITC), one of the beneficial compounds of cruciferous vegetables. The research conducted with PEITC suggests how its consumption provides protection from toxins in the environment such as the nitrosamines in food and tobacco products.

Additional projects are under development.

Publications, Book Chapters, Patents, & Meeting Abstracts

    1. Floyd, Z. E., Ribnicky, D. M., Raskin, I., Hsia, D. S., Rood, J. C., Gurley, B. J. Designing a clinical study with dietary supplements: it’s all in the details. Frontiers in Nutrition, Vol. 8, Article 779486, January 2022.
    2. Sailaja, B. S., Aita, R., Maledatu, S., Ribnicky, D., Verzi, M. P., Raskin, I. Moringa isothiocyanate-1 regulates Nrf2 and NF-κB pathway in response to LPS-driven sepsis and inflammation. PLoS ONE, Vol. 16, No. 4, article e0248691, April 2021.
    3. Vandanmagsar, B., Yu, Y., Simmler, C., Dang, T. N., Kuhn, P., Poulev, A., Ribnicky, D. M., Pauli, G. F., Floyd, Z. E. Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle. Biomedicine & Pharmacotherapy, Vol. 143, 112188, November 2021.
    4. Ribnicky, D., Kim, S. B., Poulev, A., Wang, Y., Boudreau, A., Raskin, I., Bisson, J., Ray, G. J., Chen, S-N., Richard, A., Stephens, J. M., Pauli, G. F. Prenylated coumaric acids from Artemisia scoparia beneficially modulate adipogenesis. J. Nat. Prod., article ASAP, April 2021.
    5. Bruce-Keller, A. J., Richard, A. J., Fernandez-Kim, S.-O., Ribnicky, D. M., Salbaum, J. M., Newman, S., Carmouche, R., Stephens, J. M. Fenugreek counters the effects of high fat diet on gut microbiota in mice: links to metabolic benefit. Scientific Reports, Vol. 10, No. 1, 1245, 2020.
    6. Fuller, S., Yu, Y., Allerton, T. D., Mendoza, T., Ribnicky, D. M., Floyd, Z. E. Adaptive fat oxidation is coupled with increased lipid storage in adipose tissue of female mice fed high dietary fat and sucrose. Nutrients, Vol. 12, No. 8, 2233, 2020.
    7. Boudreau, A., Burke, S. J., Collier, J. J., Richard, A. J., Ribnicky, D. M., Stephens, J. M. Mechanisms of Artemisia scoparia’s anti‐inflammatory activity in cultured adipocytes, macrophages, and pancreatic β‐cells. Obesity, Vol. 28, No. 9, pp. 1726-1735, 2020.
    8. Wolff, K., Jaja-Chimedza, A., Kim, Y., Waterman, C., Poulev, A., Raskin, I., Ribnicky, D. Moringa isothiocyanate-1 is bioaccessible and bioavailable as a stable unmodified compound. Phytochemistry Letters, Vol. 38, pp. 33-38, 2020.
    9. Rebello, C. J., Beyl, R. A., Lertora, J. J. L., Greenway, F. L., Ravussin, E., Ribnicky, D. M., Poulev, A., Kennedy, B. J., Castro, H. F., Campagna, S. R., Coulter, A. A., Redman, L. M. Safety and pharmacokinetics of Naringenin: A randomized, controlled, single ascending dose, clinical trial. Diabetes, Diabetes, Obesity and Metabolism, Vol. 22, No. 1, pp. 91-98, 2020.
    10. Yu, Y., Simmler, Ch., Kuhn, P., Poulev, A., Raskin, I., Ribnicky, D., Floyd, Z. E., Pauli, G. F. The DESIGNER approach helps decipher the hypoglycemic bioactive principles of Artemisia dracunculus (Russian Tarragon). J. Nat. Prod., Vol. 82, No. 12, pp. 3321-3329, 2019.
    11. Boudreau, A., Poulev, A., Ribnicky, D. M., Raskin, I., Rathinasabapathy, T., Richard, A. J., Stephens, J. M. Distinct fractions of an Artemisia scoparia extract contain compounds with novel adipogenic bioactivity. Frontiers in Nutrition, Vol. 6, article 18, March 08, 2019.
    12. Boudreau, A., Fuller, S., Ribnicky, D. M., Richard, A. J., Stephens, J. M. Groundsel Bush (Baccharis halimifolia) extract promotes adipocyte differentiation in vitro and increases adiponectin expression in mature adipocytes. Biology, Vol. 7, No. 2, 22, 2018.
    13. Boudreau, A., Richard, A. J., Burrell, J. A., King, W. T., Dunn, R., Schwarz, J.-M., Ribnicky, D. M., Rood, J., Salbaum, J. M., Stephens, J. M. An ethanolic extract of Artemisia scoparia inhibits lipolysis in vivo and has antilipolytic effects on murine adipocytes in vitro. Am J Physiol Endocrinol Metab., Vol. 315, No. 5, pp. E1053-E1061, 2018.
    14. Fuller, S., Yu, Y., Mendoza, T., Ribnicky, D. M., Cefalu, W. T., Floyd, Z. E. Potential adverse effects of botanical supplementation in high-fat-fed female mice. Biology of Sex Differences, Vol. 9, No. 41, published September, 2018.
    15. Wang, J., Fernandez, A. E., Tiano, S., Huang, J., Floyd, E., Poulev, A., Ribnicky, D. M., Pasinetti, G. An extract of Artemisia dracunculus L. promotes psychological resilience in a mouse model of depression. Oxidative Medicine and Cellular Longevity, Vol. 2018, Article ID 7418681, 2018.
    16. Yu, Y., Mendoza, T., Ribnicky, D., Poulev, A., Noland, R. C., Mynatt, R. L., Raskin, I., Cefalu, W. T., Floyd, Z. E. An extract of Russian Tarragon prevents obesity-related ectopic lipid accumulation. Mol. Nutr. Food Res., Vol. 62, No. 8, article 1700856, 2018.
    17. Kuhn, P., Kalariya, H., Poulev, A., Ribnicky, D. M., Jaja-Chimedza, A., Roopchand, D. E., and Raskin, I. Grape polyphenols reduce gut-localized reactive oxygen species associated with the development of metabolic syndrome in mice. PLoS|ONE, Vol. 13, No. 10, article e0198716, 2018.
    18. Rebello, C., Greenway, F., Johnson, W., Ribnicky, D., Poulev, A., Stadler, K., Coulter, A. Fucoxanthin and its metabolite fucoxanthinol do not induce browning in human adipocytes. J. Agric. Food Chem., Vol. 65, No. 50, pp. 10915-10924, 2017.
    19. Knott, E. J., Richard, A. J., Mynatt, R. L., Ribnicky, D. M., Stephens, J. M., Bruce-Keller, A. Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Scientific Reports, Vol. 7, article number 12770, 2017.
    20. Cheng, D. M., Roopchand, D. E., Poulev, A., Kuhn, P., Armas-Gutierez, I., Johnson, W. D., Oren, A., Ribnicky, D., Zelzion, E., Bhattacharya, D., Raskin, I. High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet-induced obese mice. Mol. Nutr. Food Res., Vol. 60, No. 11, pp. 2367-2378, 2016.
    21. Obanda, D. N., Zhao, P., Richard, A. J., Ribnicky, D., Cefalu, W. T., Stephens, J. M. Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner. PLoS | ONE, Vol. 11, No. 3, article e0150252, 2016.
    22. Obanda, D. N., Ribnicky, D., Yu, Y., Stephens, J., Cefalu, W. T. An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A). Scientific Reports, Vol. 6, article number 22222, 2016.
    23. Aggarwal, S., Shailendra, G., Ribnicky, D. M., Burk, D., Karki, N., Wang, M. S. Q. X. An extract of Artemisia dracunculus L. stimulates insulin secretion from beta cells, activates AMPK and suppresses inflammation. J. of Ethnopharmacology, Vol. 170, pp. 98-105, 2015.
    24. T. M. Henagan, W. T. Cefalu, D. M. Ribnicky, R. C. Noland, K. Dunville, W. W. Campbell, L. K. Stewart, L. A. Forney, T. W. Gettys, J. S. Chang, and C. D. Morrison. In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity. Genes & Nutrition, Vol. 10, No. 1, published online, January 2015.
    25. B. Vandanmagsar, K. R. Haynie, S. E. Wicks, E. M. Bermudez, T. M. Mendoza, D. Ribnicky, W. T. Cefalu and R. L. Mynatt. Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture. Diabetes, Obesity and Metabolism, Vol. 16, No. 8, pp. 728-738, 2014.
    26. D. N. Obanda, D. Ribnicky, I. Raskin, W. T. Cefalu. Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S59-S66, 2014.
    27. Kheterpal, I., Scherp, P., Kelley, L., Wang, Z., Johnson, W., Ribnicky, D. M., Cefalu, W. T. Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S43-S51. 2014.
    28. Vance, K. M., Ribnicky, D. M., Hermann, G. E., Rogers, R. C. St. John’s Wort enhances the synaptic activity of the nucleus of the solitary tract. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S37-S42, 2014.
    29. Vance, K. M., Ribnicky, D. M., Rogers, R. C., Hermann, G. E. Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract. Neuroscience Letters, Vol. 582, pp. 115-119, 2014.
    30. Richard, A. J., Burris, T. P., Sanchez-Infantes, D., Wang, Y. J., Ribnicky, D. M., and J. M. Stephens. Artemisia extracts activate PPARγ, promote adipogenesis, and enhance insulin sensitivity in adipose tissue of obese mice. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S31-S36, 2014.
    31. Wicks, S., Taylor, C. M., Luo, M., Blanchard, E., Ribnicky, D. M., Cefalu, W. T., Mynatt, R. L., Welsh, D. A. Artemisia supplementation differentially affects the mucosal and luminal ileal microbiota of diet-induced obese mice. Nutrition, Vol. 30, No. 7-8, Supplement, July-August, pp. S26-S30, 2014.
    32. Kirk-Ballard, H., Kilroy, G., Day, B. C., Wang, Z. Q., Ribnicky, D. M., Cefalu, W. T., Floyd, Z. E. An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: Potential role in the treatment of sarcopenic obesity. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S21-S25, 2014.
    33. Boudreau, A., Cheng, D. M., Ruiz, C., Ribnicky, D. M., Allain, L., Brassieur, C. R., Turnipseed, D. P., Cefalu, W. T., Floyd, Z. E. Screening native botanicals for bioactivity: An interdisciplinary approach. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S11-S16, 2014.
    34. D. M. Ribnicky, D. E. Roopchand, A. Poulev, P. Kuhn, A. Oren, W. T. Cefalu, I. Raskin. Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S4-S10, 2014.
    35. Cefalu, W. T., Floyd, Z. E., Stephens, J. M., Ribnicky, D. M. Botanicals and translational medicine: A paradigm shift in research approach. Nutrition, Vol. 30, No. 7-8, Supplement, pp. S1-S3, 2014.
    36. Fuller, S., Richard, A. J., Ribnicky, D. M., Beyl, R., Mynatt, R., and J. M. Stephens. St. John’s Wort Has Metabolically Favorable Effects on Adipocytes In Vivo. Evidence-Based Complementary and Alternative Medicine, Vol. 2014, Article ID 862575, 2014.
    37. Ribnicky, D. M., Roopchand, D. E., Oren, A., Grace, M., Poulev, A., Lila, M. A., Havenaar, R., and I. Raskin. Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chemistry, Vol. 142, No. 1, pp. 349-357, 2014.
    38. Yu, Y., Zhang, X. H., Ebersole, B., Ribnicky, D., and Wang, Z. Q. Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice. Scientific Reports, Vol. 3, Article No.: 3142, 2013.
    39. Wang, Zh. Q., Zhang, X. H., Yu, Y., Tipton, R. C., Raskin, I., Ribnicky, D., Johnson, W., and W. T. Cefalu. Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. Metabolism, Vol. 62, No. 9, pp. 1239-1249, 2013.
    40. A. Speranza, M. G. Corradini, T. G. Hartman, D. Ribnicky, A. Oren, and M. A. Rogers. Influence of emulsifier structure on lipid bioaccessibility in oil-water nanoemulsions. J. Agric. Food Chem., Vol. 61, No. 26, pp. 6505-6515, 2013.
    41. Kirk-Ballard, H., Wang, Z. Q., Acharya, P., Zhang, X. H., Yu, Y. M., Kilroy, G., Ribnicky, D., Cefalu, W. T., Floyd, Z. E. An Extract of Artemisia dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a Murine Model of Diabetes. PLOS One, Vol. 8, No. 2, article No. e57112, Feb., 2013.
    42. Richard, A. J., Amini-Vaughan, Z., Ribnicky, D. M., Stephens, J. M. Naringenin Inhibits Adipogenesis and Reduces Insulin Sensitivity and Adiponectin Expression in Adipocytes. Evidence-Based Complementary and Alternative Medicine, Vol. 2013, Article ID 549750, 10 pages, 2013.
    43. Scherp, P., Putluri, N., LeBlanc, G. J., Wang, Z. Q., Zhang, X. H., Yu, Y. M., Ribnicky, D., Cefalu, W. T., Kheterpal, I. Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L. Journal of Proteomics, Vol. 75, No. 11, pp. 3199-3210, 2012.
    44. Rojo, L., Ribnicky, D., Logendra, S., Poulev, A., Rojas, P., Kuhn, P., Dorn, R., Grace, M., Lila, M. A., and I. Raskin. In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chemistry, Vol. 131, pp. 387-396, 2012.
    45. M. A. Lila, D. M. Ribnicky, L. E. Rojo, P. Rojas-Silva, A. Oren, R. Havenaar, E. M. Janle, I. Raskin, G. G. Yousef, and M. H. Grace. Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. J. Agric. Food Chem., Vol. 60, No. 23, pp. 5763-5771, 2012.
    46. A. J. Richard, Zh. J. Amini, D. M. Ribnicky, and J. M. Stephens. St. John’s Wort inhibits insulin signaling in murine and human adipocytes. Biochimica et Biophysica Acta – Molecular Basis of Disease, Vol. 1822, No. 4, pp. 557-563, 2012.
    47. D. N. Obanda, A. Hernandez, D. Ribnicky, Y. Yu, X. H. Zhang, Zh. Q. Wang, and W. T. Cefalu. Bioactives of Artemisia dracunculus L. Mitigate the Role of Ceramides in Attenuating Insulin Signaling in Rat Skeletal Muscle Cells. Diabetes, Vol. 61, No. 3, pp. 597-605, 2012.
    48. B. M. Buehrer, D. J. Duffin, Y. R. Lea-Currie, D. Ribnicky, I. Raskin, J. M. Stephens, W. T. Cefalu, and J. M. Gimble. Tools for the identification of bioactives impacting the metabolic syndrome: screening of a botanical extract library using subcutaneous and visceral human adipose-derived stem cell-based assays. J. Nutr. Biochem., Vol. 23, No. 6, pp. 519-525, 2012.
    49. M. A. Lila, D. M. Ribnicky, L. E. Rojo, P. Rojas-Silva, A. Oren, R. Havenaar, E. M. Janle, I. Raskin, G. G. Yousef, and M. H. Grace. Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. J. Agric. Food Chem., Vol. 60, No. 23, pp. 5763-5771, 2011.
    50. Eisenman, S. W., Poulev, A., Struwe, L., Ribnicky, D. M., and I. Raskin. Qualitative variation of anti-diabetic compounds in different wild tarragon (Artemisia dracunculus L.) cytotypes. Fitoterapia, Vol. 82, No. 7, pp. 1062-1074, 2011.
    51. Wang, Z. Q., Zhang, X. H., Yu, Y., Poulev, A., Ribnicky, D., and W. T. Cefalu. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet fed mice. J. Nutr. Biochem., Vol. 22, No. 11, pp. 1064-1073, 2011.
    52. Ilnytska, O., Stütz, A. M., Park-York, M., York, A. D., Ribnicky, D., Zuberi, A., Cefalu, W. T., and G. Argyropoulos. Molecular mechanisms for activation of the Agouti-related protein and stimulation of appetite. Diabetes, Vol. 60, pp. 97-106, January 2011.
    53. Wang, Z. Q., Ribnicky, D., Zhang, X. H., Zuberi, A., Raskin, I., Yu, Y., and W. T. Cefalu. An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-AY mice. J. Nutr. Biochem., Vol. 22, No. 1, pp. 71-78, 2011.
    54. M. Dey, P. Kuhn, D. Ribnicky, V. G. Premkumar, K. Reuhl, and I. Raskin. Dietary phenethylisothiocyanate attenuates inflammation in mice. BMC Chemical Biology, 10:4, 2010.
    55. Graf, B. L., Raskin, I., Cefalu, W. T., and D. Ribnicky. Plant-derived therapeutics for the treatment of metabolic syndrome. Curr. Opin. Investig. Drugs, Vol. 11, No. 10, pp. 1107-1115, 2010.
    56. Kheterpal, I., Coleman, L., Ku, G., Wang, Z. Q., Ribnicky, D., and W. T. Cefalu. Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: A proteomics approach. Phytotherapy Research, Vol. 24, No. 9, p.p. 1278-1284, 2010.
    57. Watcho, P., Stavniichuk, R., Ribnicky, D., Raskin, I., and I. G. Obrosova. High-fat diet-induced neuropathy of prediabetes and obesity: Effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L. Mediators of Inflammation, Article No. 268547, 2010.
    58. Kellog, J., J. Wang, C. Flint, D. Ribnicky, P. Kuhn, E. G. De Mejia, I. Raskin, and M. A. Lila. Alaskan wild berry resources and human health under the cloud of climate change. J. Agric. Food Chem. 58 (7), p. 3884-3900, 2010.
    59. William T. Cefalu and David Ribnicky. Modulation of Insulin Action by Botanical Therapeutics. Obesity and Weight Management, Vol. 5, No. 6, pp. 277-281, December 2009.
    60. Stewart, L. K., Wang, Z., Ribnicky, D., Soileau, J. L., Cefalu, W. T., and T. W. Gettys. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia, Vol. 52, No. 3, p.p. 514-523, 2009.
    61. Amini, Z., Boyd, B., Doucet, J., Ribnicky, D., and J. M. Stephens. St. John’s Wort inhibits adipocyte differentiation and induces insulin resistance in adipocytes. Biochem. Biophys. Res. Commun., Vol. 388, No. 1, p.p. 146-149, 2009.
    62. D. M. Ribnicky, P. Kuhn, A. Poulev, S. Logendra, A. Zuberi, W. T. Cefalu, and I. Raskin. Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. International Journal of Pharmaceutics, Vol. 370, No. 1-2, p.p. 87-92, 2009.
    63. Wang, Z. Q., D. Ribnicky, X. H. Zhang, I. Raskin, Y. Yu, W. T. Cefalu. Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture. Metabolism, Clinical and Experimental 57: S58-S64, 2008.
    64. Barbara Schmidt, David M. Ribnicky, Alexander Poulev, Sithes Logendra, William T. Cefalu and Ilya Raskin. A Natural History of Botanical Therapeutics. Metabolism, Clinical and Experimental, Vol. 57, No. 7, pp. S3-S9, Suppl. 1, 2008.
    65. L. K. Stewart, J. L. Soileau, D. Ribnicky, Zh. Q. Wang, I. Raskin, A. Poulev, M. Majewski, W. T. Cefalu, and Th. W. Gettys. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism, Clinical and Experimental 57:S39-S46, 2008.
    66. H. Kirk, W. T. Cefalu, D. Ribnicky, Zh. Liu, and K. J. Eilertsen. Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome. Metabolism Clinical and Experimental, Vol. 57, Suppl. 1, S16-S23, 2008.
    67. Burns Kraft, T. F., M. Dey, R. B. Rogers, D. M. Ribnicky, D. M. Gipp, W. T. Cefalu, I. Raskin, and M. A. Lila. Phytochemical composition and metabolite performance enhancing activity of dietary berries traditionally used by Native North Americans. J. of Agricultural and Food Chemistry, Vol. 56, No. 3, pp. 654-660, 2008.
    68. Ribnicky, D. M., A. Poulev, B. Schmidt, W. T. Cefalu, and I. Raskin. Evaluation of botanicals for improving human health. Am. J. Clinical Nutrition, Vol. 87, No. 2, pp. 472S-475S, 2008.
    69. Cefalu, W. T., J. Ye, A. Zuberi, D. M. Ribnicky, I. Raskin, Z. Liu, Z. Q. Wang, P. J. Brantley, L. Howard, and M. Lefevre. Botanicals and the metabolic syndrome. Am. J. Clinical Nutrition, Vol. 87, No. 2, pp. 481S-487S, 2008.
    70. Govorko, D., Logendra, S., Wang, Y., Esposito, D., Komarnytsky, S., Ribnicky, D., Poulev, A., Cefalu, W. T., and I. Raskin. Polyphenolic Compounds from Artemisia dracunculus L. Inhibit PEPCK Gene Expression and Gluconeogenesis in an H4IIE Hepatoma Cell Line. AJP: Endocrinology and Metabolism, Vol. 293, No. 6, p.p. E1503-E1510, 2007.
    71. Barbara M. Schmidt, David M. Ribnicky, Peter E. Lipsky and Ilya Raskin. Revisiting the ancient concept of botanical therapeutics. Nature Chemical Biology, Vol. 3, No. 7, p.p. 360-366, 2007.
    72. Christopher Okunji, Slavko Komarnytsky, Georgie Fear, Alexander Poulev, David M. Ribnicky, Peter I. Awachie, Yoichiro Ito, and Ilya Raskin. Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography. J. of Chromatography A, Vol. 1151, No. 1-2, 45-50, 2007.
    73. S. Logendra, D. M. Ribnicky, H. Yang, A. Poulev, J. Ma, E. J. Kennelly, and I. Raskin. Bioassay-guided fractionation and isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry, 67, No. 14, 1539-1546, 2006.
    74. David M. Ribnicky, Alexander Poulev, Malcolm Watford, William T. Cefalu, and Ilya Raskin. Antihyperglycemic Activity of TARRALIN™, an Ethanolic Extract of Artemisia dracunculus L. Phytomedicine, Vol. 13, No. 8, 550-557, 2006.
    75. Dey, M., Ribnicky, D., Kurmukov, A. G., and Ilya Raskin. Transcriptional modulation and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate. Journal of Pharmacology and Experimental Therapeutics; 317(1), 326-333, 2006.
    76. David M. Ribnicky, Alexander Poulev, Joseph O’Neal, Gary Wnorowski, Dolores E. Malek, Ralf Jäger, Ilya Raskin. Toxicological Evaluation of the Ethanolic Extract of Artemisia dracunculus L. for Use as a Dietary Supplement and in Functional Foods. Food and Chemical Toxicology, Vol. 42/4, pp 585-598, 2004.
    77. Ribnicky, D. M., A. Poulev, and I. Raskin. The determination of salicylates in Gaultheria procumbens for use as a natural Aspirin alternative. Journal of Nutraceuticals, Functional and Medical Foods. Vol. 4, No. 1, 2003.
    78. Ilya Raskin, David M. Ribnicky, Slavko Komarnytsky, Nebojša Ilić, Alexander Poulev, Nikolai Borisjuk, Anita Brinker, Diego A. Moreno, Christophe Ripoll, Nir Yakoby, Joseph M. O’Neal, Teresa Cornwell, Ira Pastor and Bertold Fridlender. Plants and human health in the twenty-first century. Trends in Biotechnology, Vol. 20, No. 12, pp. 522-531, 2002.
    79. David M. Ribnicky, W.-S. Hu, Jerry D. Cohen, and Todd J. Cooke (2002). An auxin surge following fertilization in carrot: a plausible mechanism for regulating plant totipotency. Planta 214: 505-509
    80. David M. Ribnicky, Alexander Poulev, Eve Henry, and Ilya Raskin (2001). Seed of Barbarea verna as a rich source of phenethyl isothiocyanate to provide natural protection from environmental and dietary toxins. Journal of Nutraceuticals, Functional and Medical Foods: 3(3) 43-65
    81. Cary Leizer, David Ribnicky, Alexander Poulev, Slavik Dushenkov, and Ilya Raskin (2000). The composition of hemp seed oil and its potential as an important source of nutrition. Journal of Nutraceuticals, Functional and Medical Foods: 2(4) 35-53
    82. David M. Ribnicky, Vladimir Shulaev, and Ilya Raskin (1998). Intermediates of salicylic acid biosynthesis in tobacco. Plant Physiol. 118: 565-572
    83. David M. Ribnicky, Jerry D. Cohen, and Todd J. Cooke (1998). Microscale analysis of free and conjugated indole-3-acetic acid in milligram amounts of plant tissue using a benchtop gas chromatograph-mass spectrometer. Planta 204: 1-7
    84. Michele Barker-Bridgers, David M. Ribnicky, Jerry Cohen and Alan M. Jones (1998). Red light-regulated growth. Changes in the abundance of indoleacetic acid in the maize (normal Zea mays L. mesocotyl). Planta 204: 207-211
    85. David M. Ribnicky, Nebojša Ilić, Jerry D. Cohen and Todd J. Cooke (1996). The effects of exogenous auxins on endogenous indole-3-acetic acid metabolism. Plant Physiol. 112: 549-558
    86. Jerry D. Cohen, Janet P. Slovin, Kristina Bialek, Ellen G. Sutter, Bruce G. Baldi, Lech Michalczuk, David M. Ribnicky, Yuen Yee Tam, and Todd J. Cooke (1992). Stable isotope techniques for the analysis of indole auxin metabolism in normal and mutant plants. In: C.M. Karssen, L.C. Van Loon, and D. Vreugdenhil, eds, Progess in Plant Growth Regulation, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 859 – 873
    87. Lech Michalczuk, David M Ribnicky, Todd J. Cooke, and Jerry D. Cohen (1992). Regulation of indole-3-acetic acid biosynthetic pathways in carrot cell cultures. Plant Physiol. 100: 1346-1353

    Book Chapters

    • Rojo, L. E., D. Roopchand, B. Graf, D. Cheng, D. Ribnicky, and I. Raskin. Role of anthocyanins in skin aging and UV-induced skin damage. In: Anthocyanins in Health and Disease. T. C. Wallace (ed.), CRC Press, ISBN 9781439894712, 2013.
    • Roopchand, D., L. E. Rojo, D. Ribnicky, and I. Raskin. Anthocyanins in the Prevention of Metabolic Syndrome and Type-2 Diabetes. In: Anthocyanins in Health and Disease. T. C. Wallace (ed.), CRC Press, ISBN 9781439894712, 2013.

    Patents

    • Ribnicky, D. M., Poulev, A., and Raskin, I. Methods of administering gaultherin-containing compositions. U. S. patent # 7,033,618, April 25, 2006.
    • Ribnicky, D. M., and I. Raskin. Method for treating type 2 diabetes with an extract of Artemisia. U. S. patent # 6,893,627, May 17, 2005.
    • Ribnicky, D. M., A. Poulev, and I. Raskin. Phenethylisothiocyanate Nutraceutical Compositions and Methods. U.S. patent # 6,348,220, February 19, 2002.

    Patent Applications

    • Ribnicky, D. M., and I. Raskin. Berry Preparations For Treatment Of Diabetes And Metabolic Syndrome. U. S. Patent application 20090176718, July 9, 2009.
    • Ribnicky, D. M., Logendra, S., Poulev, A., Cefalu, W. T., Raskin, I. Compounds from an extract of Artemisia and methods for treating disorders. U. S. Patent application 20070224301, September 27, 2007.
    • Ribnicky, D. M., Dey, M., Raskin, I. Anti-inflammatory activity of phenethylisothiocyanate (PEITC) and the Barbarea verna seed preparation containing this compound. U. S. Patent application 20070042061, February 22, 2007.
    • Ribnicky, D. M., and I. Raskin. Methods for treating disorders using plant extracts. U. S. Patent application 20050069598, March 31, 2005.
    • Ribnicky, D. M., and I. Raskin. Methods for Treating Disorders Using Plant Extracts. U. S. Patent application 20030072822, April 17, 2003.
    • Ribnicky, D. M., Poulev, A., Raskin, I. Methods of administering gaultherin-containing compositions. U. S. Patent application 20030161898, August 28, 2003.
    • Ribnicky, D. M., Poulev, A., Raskin, I. Recovery of gaultherin from plants. U. S. Patent application 20020031562, March 14, 2002.

    Abstracts

    1. Floyd, Z. E., Boudreau, A., Cheng, D. M., Ruiz, C., Ribnicky, D., Brassieur, C. R., Allain, L., Cefalu, W. T. Screening native botanicals for bioactivity: an interdisciplinary approach. Hortscience, Vol. 50, No. 9, p. S99, Presentation at the annual conference of the Am. Soc. Hort. Sci., New Orleans, LA. August 2015.
    2. Jacqueline M. Stephens, David M. Ribnicky, and Allison J. Richard. Botanical extracts modulate adipocyte function and insulin sensitivity in vitro and in vivo. FASEB Journal, Vol. 27, Meeting Abstract Supplement, 637.38, 2013.
    3. Aggarwal, S., Wang, Q., Shailendra, G., Ribnicky, D., Burk, D., Cefalu, W. T. An Extract of Artemisia drancunculus L. Stimulates Insulin Secretion from beta cells, Activates AMPK and Suppresses Inflammation. Pancreas, Vol. 41, No. 8, p. 1345, Meeting Abstract, 2012.
    4. Moul Dey, Yi Liu, Kenneth Reuhl, Ilya Raskin, David Ribnicky, and Peter Kuhn. Alleviation of bowel inflammation by dietary phenethylisothiocyanate in a mouse ulcerative colitis model. FASEB Journal, Vol. 25, Meeting Abstract Supplement, 599.6, 2011.
    5. Zhong Q. Wang, Yongmei Yu, Xian H. Zhang, David Ribnicky, William T. Cefalu. Effect of Ecdysterone on Hepatic AMP Activated Protein Kinase in Mice Fed with a High-Fat Diet. Abstract No.: 1684-P. Abstract for the 71st Scientific Sessions, American Diabetes Association, June 24 – 28, San Diego, CA, USA, 2011.
    6. Diana N. Obanda, David Ribnicky, Zhong Q. Wang, William T. Cefalu. Mitigating Ceramide Induced Insulin Resistance in Rat Skeletal Muscle Culture Using Bioactives of Artemisia dracunculus L. Abstract No.: 1501-P. Abstract for the 71st Scientific Sessions, American Diabetes Association, June 24 – 28, San Diego, CA, USA, 2011.
    7. Zhong Q. Wang, Toniya Acharya, Xian Zhang, Heather Kirk-Ballard, Yongmei Yu, Gail Kilroy, David Ribnicky, William T. Cefalu, Z. Elizabeth Floyd. Botanical Modulation of the Ubiquitin Proteasome System in Skeletal Muscle. Abstract No.: 1733-P. Abstract for the 71st Scientific Sessions, American Diabetes Association, June 24 – 28, San Diego, CA, USA, 2011.
    8. Julie Doucet, Zhaleh Amini, David M. Ribnicky, Jacqueline M. Stephens. St. John’s Wort Modulates Adipogenesis and Induces Insulin Resistance in Cultured Fat Cells. Abstract No.: 2330-PO. Abstract for the 69th Scientific Sessions, American Diabetes Association, June 05 – 09, New Orleans, LA, USA, 2009.
    9. David Ribnicky, Alexander Poulev, Peter Kuhn, Sithes Logendra, Aamir Zuberi, William Cefalu, and Ilya Raskin. A Chalcone from an Extract of Artemisia dracunculus L. Is Glucuronidated In Vivo and Has Antidiabetic Activity Comparable to Metformin. Abstract No.: 1995-PO. Abstract for the 69th Scientific Sessions, American Diabetes Association, June 05 – 09, New Orleans, LA, USA, 2009.
    10. Zhaleh Amini, Julie Doucet, David M. Ribnicky, and Jacqueline M. Stephens. Botanical extracts from St. John�s Wort inhibit adipogenesis and induce insulin resistance. FASEB Journal, Vol. 23, Meeting Abstract Supplement, 559.3, 2009.
    11. David Ribnicky, Alexander Poulev, Peter Kuhn, Sithes Logendra, Aamir Zuberi, William Cefalu, and Ilya Raskin. Enhancement of the in vivo Antidiabetic Activity of an Extract of Artemisia dracunculus L. by Improving the Bioavailability of its Active Components. Abstract No.: 2079-PO. Abstract for the 68th Scientific Sessions, American Diabetes Association, June 06 – 10, San Francisco, CA, USA, 2008.
    12. Zhong Q. Wang, Yongmei Yu, Jianhua Qin, Xian H. Zhang, Aamir Zuberi, Ilya Raskin, David Ribnicky, William T. Cefalu. Effect of an Alcholic Extract of Artemisia dracunculus L. on Gene Expression Profiles in Skeletal Muscle of KK-AY Mice. Abstract No.: 2560-PO. Abstract for the 68th Scientific Sessions, American Diabetes Association, June 06 – 10, San Francisco, CA, USA, 2008.
    13. Xian H. Zhang, Zhong Wang, Jianhua Qin, David M. Ribnicky, Ilya Raskin, William T. Cefalu, Aamir R. Zuberi. Mouse Genotype Dependent Effects of a Known Insulin Sensitizer, Artemisia dracunculus L. (Russian Tarragon). Abstract No.: 2508-PO. Abstract for the 68th Scientific Sessions, American Diabetes Association, June 06 – 10, San Francisco, CA, USA, 2008.
    14. Ann A. Coulter, David Ribnicky, Sunita Gupta, George Argyropoulos, Zhong Q. Wang, Ilya Raskin, William T. Cefalu. Effect of an Alcoholic Extract of Artemisia dracunculus L on Carbohydrate Metabolism in Humans. Abstract No.: 469-P. Abstract for the 68th Scientific Sessions, American Diabetes Association, June 06 – 10, San Francisco, CA, USA, 2008.
    15. Ann A. Coulter, George Argyropoulos, David M. Ribnicky, Xian Zhang, Zhang Q. Wang, William T. Cefalu. Reduction in PTP-1B protein levels in skeletal muscle by an alcoholic extract of Artemisia dracunculus L. is phenotype dependent. Abstract No.: 1280-P. Abstract for the 67th Scientific Sessions, American Diabetes Association, June 22 – 26, Chicago IL, USA, 2007.
    16. Zhong Q. Wang, David M. Ribnicky, Aamir Zuberi, Xian Zhang, Xin Ye, Jianhua Qin, Leslie Son, Ilya Raskin, William T. Cefalu. An Extract Of Artemisia dracunculus L. Increases Insulin Sensitivity And Enhances Cellular Insulin Signaling In KK-AY Mice. Abstract No.: 0610-P. Abstract for the 67th Scientific Sessions, American Diabetes Association, June 22 – 26, Chicago IL, USA, 2007.
    17. Leslie S. Son, Jianhua Qin, Zhong Q. Wang, Xian Zhang, David Ribnicky, William T. Cefalu. Effect of an active fraction of Artemisia dracunculus L. on cellular insulin signaling in primary human skeletal muscle culture. Abstract No.: 2168-PO. Abstract for the 67th Scientific Sessions, American Diabetes Association, June 22 – 26, Chicago IL, USA, 2007.
    18. David Ribnicky, Alexander Poulev, Peter Kuhn, Sithes Logendra, Aamir Zuberi, William Cefalu, and Ilya Raskin. Bioavailability assessment of an extract of Artemisia dracunculus L. with antidiabetic activities in vitro and in vivo. Abstract No.: 2205-PO. Abstract for the 67th Scientific Sessions, American Diabetes Association, June 22 – 26, Chicago IL, USA, 2007.
    19. Moul Dey, David Ribnicky, Anvar Kurmukov, and Ilya Raskin. Phenethylisothiocyanate from Barbarea verna as anti-inflammatory agent. FASEB Journal, Vol. 20, Meeting Abstract Supplement, LB551, 2006.
    20. Dmitry Govorko, Sithes Logendra, David M. Ribnicky, Alexander Poulev, Jun Ma, Hui Yang, Edward J. Kennelly, and Ilya Raskin. Bioactivity-guided isolation of anti-diabetic compounds from an extract of Artemisia dracunculus L. using a novel PEPCK gene expression assay. Abstract No.: 478-P. Abstract for the 66th Scientific Sessions, American Diabetes Association, June 9 – 13, Washington DC, USA, 2006.
    21. Sithes Logendra, David M. Ribnicky, Alexander Poulev, Jun Ma, Hui Yang, Edward J. Kennelly, and Ilya Raskin. Isolation of novel inhibitors of human aldose reductase activity from an anti-diabetic extract of Artemisia dracunculus L. Abstract No.: 520-P. Abstract for the 66th Scientific Sessions, American Diabetes Association, June 9 – 13, Washington DC, USA, 2006.
    22. Zhong Q. Wang, David M. Ribnicky, Sithes Logendra, Alexander Poulev, Jun Ma, Hui Yang, Edward J. Kennelly, Ilya Raskin, and William T. Cefalu. Bioactives from an extract of Artemisia dracunculus L. exhibit potent inhibitory activities for PTP-1B in human skeletal muscle culture. Abstract No.: 613-P. Abstract for the 66th Scientific Sessions, American Diabetes Association, June 9 – 13, Washington DC, USA, 2006.
    23. Dubuisson, O. S., Macgowan, J., Ribnicky, D. M., Raskin, I., Cefalu, W. T., Zuberi, A. Hypoglycemic and hypoinsulinemic effects of a dietary supplement, Artemisia dracunculus (Russian Tarragon), in obese and diabetic mice. Abstract No.: 2510-PO. Abstract for the 66th Scientific Sessions, American Diabetes Association, June 9 – 13, Washington DC, USA, 2006.
    24. Lefevre, M., Wang, Z. Q., Ribnicky, D. M., Raskin, I., Zhang, X. H., Hulver, M., Civitarese, A., Ye, J., Cefalu, W. T. Use of hierarchical cluster analysis to prioritize secondary screening of bioactive botanicals for treatment of insulin resistance. Abstract No.: 2084-PO. Abstract for the 66th Scientific Sessions, American Diabetes Association, June 9 – 13, Washington DC, USA, 2006.
    25. David M. Ribnicky, Alexander Poulev, Sithes Logendra, William T. Cefalu, Zhong Wang, and Ilya Raskin. The development of an extract of Artemisia dracunculus for decreasing the insulin resistance associated with diabetes, from concept to clinic. Gordon Research Conference on Agricultural Sciences “Adding more value to production agriculture”, February 13 – 18, Ventura, California, USA, 2005.
    26. Raskin, I. and D. Ribnicky. Phenethyl isothiocyanate (PEITC): A secondary antioxidant with unique pharmacological activities. Abstracts of Papers of the American Chemical Society, Vol. 230, p. U35. Meeting Abstract: 65-AGFD, 2005.
    27. Zhong Wang, Xian M. Zhang, David M. Ribnicky, William Cefalu. Effect of a Alcoholic Extract of Artemisia dracunculus (Tarralin™) on Glucose Uptake in Human Skeletal Muscle Culture. Abstract No.: 1706-P. Abstract for the 64th Scientific Sessions of the American Diabetes Association. June 4 – 8, Orlando, Florida, USA, 2004.
    28. David M. Ribnicky, Alexander Poulev, Malcolm Watford, Ilya Raskin, Zhong Q. Wang. The Effect of Tarralin™, an Extract of Artemisia dracunculus L., on Blood Glucose Parameters in Diabetic Animal Models. Abstract No.: 1703-P. Abstract for the 64th Scientific Sessions of the American Diabetes Association. June 4 – 8, Orlando, Florida, USA, 2004.
    29. David M. Ribnicky, Alexander Poulev, and Ilya Raskin. Development of PMI-5001, a Natural Salicylate from Gaultheria procumbens L. for Cardiovascular Health. (Download poster in pdf-format). Abstract for the University/Industry Workshop Advances in Therapeutic Agents Discovery & Development. January 29, 2002, New Brunswick, NJ, USA.
    30. David M. Ribnicky, Ilan Chet, Iris Yedidya, Miriam Abramsky, Dana Frisem, Alexander Poulev, and Ilya Raskin. Extracts of Gaultheria procumbens L. promote disease resistance in Cucumis sativus challenged with Pseudomonas syringae pv. Lachrymans. (Download poster in pdf-format). Abstract for the Annual Meeting of the American Society of Plant Biologists, July 21 – 25, 2001, Providence, RI, USA.
    31. David M. Ribnicky, Alexander Poulev, and Ilya Raskin(1999). Determination of salicylates in Gaultheria procumbens using LC-MS and GC-MS. Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    32. David M. Ribnicky, Vladimir Shulaev, and Ilya Raskin (1997). Benzaldehyde as an intermediate in salicylic acid biosynthesis in tobacco. Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    33. David M. Ribnicky, Jerry D. Cohen, and Todd J. Cooke (1996). The role of auxin in carrot zygotic embryogenesis. Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    34. Michele Barker-Bridgers, Alan M. Jones, David M. Ribnicky, Terri L. Lomax, and Jerry D. Cohen (1996). The diageotropica phenotype – is it a result of auxin conjugation? Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    35. David M. Ribnicky, Jerry D. Cohen, and Todd J. Cooke (1995). Microscale analysis of free and conjugated IAA by GC-MS-SIM. Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    36. David M. Ribnicky, Jerry D. Cohen, and Todd J. Cooke (1995). A microtechnique for the analysis of free and conjugated IAA by GC-MS-SIM. Abstract for 15th International Conference on Plant Growth Substances.
    37. Michele Barker-Bridgers, Alan M. Jones, David M. Ribnicky, and Jerry D. Cohen (1995). Red light causes auxin to decrease preferentially within the epidermis of the maize mesocotyl. Abstract for the Annual Meeting of the American Society of Plant Physiologists.
    38. Jerry D. Cohen, Janet P. Slovin, David M. Ribnicky, Carol Auer, Gary A. Kuleck, Yuen Yee Tam, and Todd J. Cooke (1994). Hormone metabolism during plant regeneration from culture. Research on Plant Growth Substances (a post-lBC symposium on plant hormones), Univ. of Tokyo, Japan; Abstract pp. 5-6.
    39. David M. Ribnicky, Jerry D. Cohen, and Todd J. Cooke (1993). Control of auxin metabolism in relation to carrot somatic embryogenesis. Abstract for the Annual Meeting of the American Society of Plant Physiologists
    40. David M. Ribnicky, Lech Michalczuk, Jerry D. Cohen, and Todd J. Cooke (1992). Auxin metabolism of carrot somatic embryogenesis. Abstract for the Annual Meeting of the American Society of Plant Physiologists
    41. David M. Ribnicky, Lech Michalczuk, Jerry D. Cohen, and Todd J. Cooke (1991). Auxin relationships during carrot somatic embryogenesis. Abstract for the 14th International Conference on Plant Growth Substances