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Tuğba Boyunegmez Tümer, Visiting Scientist

Education

Ph. D. 2004-2009 Middle East Technical University (Ankara, Turkey), Natural and Applied Sciences, Graduate Program of Biochemistry.

  • Thesis: “Pharmacogenetics of childhood Acute Lymphoblastic Leukemia: Investigation of frequency of TPMT risk alleles for Thiopurine toxicity and the role of SULT1A1, EPHX1 Polymorphisms as risk factor for development of the disease”.
M. Sc. 2002-2004 Middle East Technical University (Ankara, Turkey), Natural and Applied Sciences, Graduate Program of Biochemistry.

  • Thesis: “Biochemical Monitoring of Toxic and Carcinogenic Organic Pollutants Along the Izmir Bay After the Great Canal Project and Possible Health Effects”.
B. Sc. 1996-2001 Middle East Technical University (Ankara, Turkey), Department of Biological Sciences.

Research and Work Experience

2013-2014 Visiting Scientist, Rutgers University, Dept. of Plant Biology and Pathology, Ilya Raskin Laboratory, New Brunswick NJ, USA.
Nov. 2009-Present Assistant Professor, Çanakkale Onsekiz Mart University, Department of Molecular Biology and Genetics, Çanakkale, Turkey.
Aug. 2009-Nov. 2009 Research Scientist, Central Laboratory, Research and Development Center, Middle East Technical University, Ankara, Turkey.
2002-2009 Research Assistant, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.

 

Projects Involved

  1. Project Title: Elucidation of the Potential Ameliorating Effect and Mechanisms of Lavandula stoechas on the Factors Forming Insulin Resistance and Dyslipidemia as Components of Metabolic Syndrome at the Molecular Level”. Supported by Scientific and Technological Research Council of Turkey (TUBITAK), in the Program of National Young Investigator Career Development. Accepted in July 13, 2012-Current. Project Number: 112T442. Project Leader.

  2. Project Title: “Elucidation of the Effects of Natural Spirulina Preparation on Xenobiotic Metabolism at the Molecular Level”. Supported by TUBITAK in the Program of Fast Support. Supported for the period of October 15, 2011-October 15, 2012, Completed. Project Number: 111T582. Project Leader.

  3. Project Title: “The Monitoring of Persistent and Toxic Organic Chemical Pollutants in Izmir Bay by using Biotechnological Methods”. Supported by TUBITAK in the Program of Scientific and Technological Research Project Support. Supported for the period of July 1, 2006-July 1, 2009, Completed. Project Number: 102Y044. Investigator.

Publications

  1. Waterman, C., Rojas-Silva, P., Tümer, T. B., Kuhn, P., Richard, A. J., Wicks, S., Stephens, J. M., Wang, Z., Mynatt, R., Cefalu, W., and I. Raskin. Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance and hepatic gluconeogenesis in mice. Mol. Nutr. Food Res., e-pub ahead of print, 2015.

  2. T. B. Tümer, P. Rojas-Silva, A. Poulev, I. Raskin, and C. Waterman. Direct and Indirect Antioxidant Activity of Polyphenol and Isothiocyanate-Enriched Fractions from Moringa oleifera. J. Agric. Food Chem., Vol. 63, No. 5, pp. 1505-1513, 2015.

  3. Savranoglu, S., Tümer, T. B. Inhibitory Effects of Spirulina platensis on Carcinogen-Activating Cytochrome P450 Isozymes and Potential for Drug Interactions. International Journal of Toxicology, Vol. 32, No. 5, pp. 376-384, 2013.

  4. Tümer, T. B., Sahin, G., Arinç, E. Association between Polymorphisms of EPHX1 and XRCC1 Genes and the Risk of Childhood Acute Lymphoblastic Leukemia. Archives of Toxicology, Vol. 86, No. 3, pp. 431-439, 2012.

  5. Tümer, T. B., Yilmaz, D., Tanrikut, C., Sahin, G., Ulusoy, G., Arinç, E. DNA Repair XRCC1 Arg399Gln Polymorphism alone, and in Combination with CYP2E1 Polymorphisms Significantly Contribute to the Risk of Development of Childhood Acute Lymphoblastic Leukemia. Leukemia Research, Vol. 34, No. 10, pp. 1275-1281, 2010.

  6. Tümer, T. B., Ulusoy, G., Adali, O., Sahin, G., Gozdasoglu, S., Arinç, E. The Low frequency of defective TPMT alleles in Turkish population: A study on Pediatric Patients with Acute Lymphoblastic Leukemia. American Journal of Hematology, Vol. 82, No. 10, pp. 906-910, 2007.

  7. Ulusoy, G., Adali, O., Tümer, T. B., Sahin, G., Gozdasoglu, S., Arinç, E. Significance of Genetic Polymorphisms at Multiple Loci of CYP2E1 in The Risk of Development of Childhood Acute Lymphoblastic Leukemia. Oncology, Vol. 72, No. 1-2, pp. 125-131, 2007.

Selected Symposia and Conference Proceedings

  1. Tümer, T. B., Savranoglu, S., Atmaca, P., Sen, A., Arslan, S. (2012) Role of Genetic Polymorphism of DNA Repair Gene XRCC1 in the Modulation of DNA Damage in Farmers Occupationally Exposed to Pesticides: A Preliminary Study From Denizli, Turkey. Abstract from 12th European ISSX Meeting, Drug Metabolism Reviews, Vol. 44, in press, 2012.

  2. Tümer, T. B., Yilmaz, D., Tanrikut, C., Ulusoy, G., Arinç, E. EPHX1 Gene Tyr113H is Variant Alone, or in Combination with XRCC1 Arg399Gln Polymorphism Significantly and Considerably Increased the Risk of Childhood Acute Lymphoblastic Leukemia. Drug Metabolism Reviews, Vol. 42, Suppl. 1, pp. 259-260, 2010.

  3. Tanrikut, C., Boyunegmez Tümer, T., Arinç, E. Protective Role of DNA Repair XRCC3 Thr241Met Polymorphism on Development of Childhood Acute Lymphoblastic Leukemia. Drug Metabolism Reviews, Vol. 42, Suppl. 1, pp. 264-265, 2010.

  4. Arinç, E., Tümer, T., Yilmaz, D., Cihan Tanrikut, and Gulen Ulusoy. The role of DNA repair gene XRCC1 Arg194Trp and Arg399Gln polymorphisms as risk factor for the development of childhood acute lymphoblastic leukemia: A study on Turkish population including the case only analysis of interactive effect of cigarette smoke. Drug Metabolism Reviews, Vol. 41, Suppl. 3, p. 158, 2009.

  5. Tümer, T., Ulusoy, G., Adali, O., Sahin, G., Arinç, E. The Role Of SULT1A1 and EPHX1 Polymorphisms as Risk Modifiers In Childhood Acute Lymphoblastic Leukemia in Turkish Population: A Case-Control Study. Drug Metabolism Reviews, Vol. 40, Suppl. 1, pp. 141-142, 2008.

  6. Ulusoy, G., Tümer, T., Adali, O., Sahin, G., Arinç, E. Significance of CYP2E1 and NQO1 Polymorphisms in the risk development of childhood acute lymphoblastic leukemia. Drug Metabolism Reviews, Vol. 40, Suppl. 1, pp. 134-135, 2008.

  7. Tümer, T., Ulusoy, G., Adali, O., Sahin, G., Gozdasoglu, S., Arinç, E. Genetic polymorphism of Thiopurine Methyltransferase Enzyme in Children with Acute Lymphoblastic Leukemia in Turkish population: A Preliminary Study on TPMT *3A and TPMT *3C allele. Drug Metabolism Reviews, Vol. 38, Suppl. 2, p. 205, 2006.

  8. Tümer, T., Arinç, E. Screening of PAH/PCB Type Pollution along Izmir Bay by CYP1A Levels and EROD Activities of Three Different Fish Species. The FEBS Journal, Vol. 273, Suppl. 1, p. 292, 2006.

  9. Tümer, T., Arinç, E. Biotransformation Enzyme Activities of Feral Annular Seabream along the Pollution Gradient of Izmir Bay: EROD Activities Correlate with MROD but not with Other Monooxygenase Activities. Marine Environmetal Research, Vol. 62, Suppl. 1, p. 52, 2005.

Meetings and Congresses Attended

  1. June 17-21, 2012. 19th International Symposium on Microsomes and Drug Oxidations and 12th European ISSX Meeting, Noordwijk aan Zee, The Netherlands. Poster Presentation.

  2. June 21-25, 2010. 20th National Biology Congress (With International Participation) Denizli, Turkey. Oral Presentation.

  3. September 4-8, 2010. 9th International Meeting of the International Society for the Study of Xenobiotics(ISSX), Istanbul, Turkey. Poster Presentation.

  4. May 30 – June 1, 2009. The Society of Turkish Toxicology with International Participation, Ankara, Turkey. Oral Presentation.

  5. May 18-22, 2008. 10th European ISSX Regional Meeting, Vienna, Austria. Poster Presentation.

  6. June 15-20, 2007. ESF-UB Conference in Biomedicine, Pharmacogenetics and Pharmacogenomics, Sant Feliu de Guixols, Spain. Poster Presentation.

  7. October 22-26, 2006. 14th North American ISSX Meeting, Rio Grande, Puerto Rico, USA. Oral Presentation.

  8. June 24-29, 2006. 31st FEBS Congress, Istanbul, Turkey. Poster Presentation.

  9. June 19-22, 2005. 13th PRIMO Meeting, Alessandria, Italy. Oral Presentation.

  10. October 3-8, 2004. 19th Eurepean Workshop on Drug Metabolism, Kemer-Antalya, Turkey. Poster Presentation.

  11. October 12-15, 2003. 13th Balkan Biochemical Biophysical Days and Meeting on Metabolic Disorders, Kusadasi, Turkey. Poster Presentation.