{"id":1079,"date":"2019-11-07T23:38:41","date_gmt":"2019-11-07T23:38:41","guid":{"rendered":"http:\/\/sites.rutgers.edu\/ilya-raskin-lab\/?page_id=1079"},"modified":"2019-11-07T23:48:55","modified_gmt":"2019-11-07T23:48:55","slug":"thirumurugan-rathinasabapathy","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/thirumurugan-rathinasabapathy\/","title":{"rendered":"Thirumurugan Rathinasabapathy, Postdoctoral Associate"},"content":{"rendered":"<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Education<\/strong><\/h2>\n<p><\/p>\n<table style=\"border:1px solid #ccc\" cellpadding=\"10\">\n<tr>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;width:16%;vertical-align:top\"><strong>Ph. D.<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;width:12%;vertical-align:top\"><strong>2005<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\">Medicinal Chemistry, BITS, Pilani, India.<\/td>\n<\/tr>\n<tr style=\"background-color:#f9f9f9\">\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\"><strong>M. Pharm.<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\"><strong>2000<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\">Pharmaceutical Chemistry, BHU, Varanasy, India.<\/td>\n<\/tr>\n<tr>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\"><strong>B. Pharm.<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\"><strong>1997<\/strong><\/td>\n<td style=\"font-family:Trebuchet MS;font-size: 1rem;vertical-align:top\">Pharmaceutical Sciences, Madurai Medical College, Tamil Nadu, India.<\/td>\n<\/tr>\n<\/table>\n<p><\/p>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Research Experience<\/strong><\/h2>\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Drug design &#8211; Lead optimization of transcriptional modulators (anticancer activity).<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Multi-step synthesis of heterocyclic compounds, drug intermediates, molecular scaffolds for libraries. Process development for known compounds for large scale production and planning new routes for unknown compounds.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Isolation and characterization of natural products from plant sources.<\/li>\n<\/ul>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Professional Skills &amp; Exposure<\/strong><\/h2>\n<p><\/p>\n<ul>\n<\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Well trained in the synthesis and development of lead molecules to pre-clinical candidates.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Experience in multi-step synthesis, well-versed with modern synthetic organic chemistry techniques, familiarity with handling air and moisture sensitive reagents.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Efficient problem solving capabilities in process development; yield improvement and standardization for cost effective process.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Good practical knowledge in various chromatographic techniques such as column chromatography, Preparative TLC, HPLC (Analytical &amp; Preparative) and FCPC (Fast Centrifugal Partition Chromatography).<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Working experience with B&#252;chi syncore parallel synthesizer, Biostage microwave synthesizer, CombiFlash Companion Flash chromatography, NMR, IR and UV-Visible spectroscopy.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Experienced in the isolation and characterization of bioactive compounds from plant crude extracts.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Experience in the interpretation of various NMR spectra such as <sup>1<\/sup>H NMR, <sup>13<\/sup>C NMR, DEPT, COSY, HMQC and HMBC.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Skilled in efficient interpretation of other spectral data such as UV, IR, MS and elemental analysis.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Working knowledge of databases like ISIS base, Chemdraw, Chemsketch, Alchemy 2000, MDL Crossfire commander, Reaxys, Sci-Finder as well as<br \/>\nscientific information retrieval using internet and also good knowledge of patent search databases and its legal aspects.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Great exposure to certain screening methods like cell based assays (3T3-L1 &amp; H4IIE cells) and biochemical assay (determination of GABA level in rat brain).<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Experience in common <i>in vitro<\/i> pharmacological and microbiological assays and have great hands on experimental animal handling.<\/li>\n<\/ul>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Honors and Fellowships<\/strong><\/h2>\n<p><\/p>\n<ul>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Registered Pharmacist, under the Pharmacy Council of India<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">GATE qualified (97.11 percentile, All India Rank &#8211; 64)<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Recipient of Junior Research Fellowship (UGC, Govt. of India)<br \/>\n<\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Recipient of Senior Research Fellowship (CSIR, Govt. of India)<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Member of The American Chemical Society<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Member of Indian Pharmacy Graduates Association<\/li>\n<\/ul>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Publications<\/strong><\/h2>\n<p><\/p>\n<ol>\n<\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">S. Komarnytsky, D. Esposito, <strong>Th. Rathinasabapathy<\/strong>, A. Poulev, and I. Raskin. Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of Melanocortin Pathway and BDNF in Animal Model. J. Agric. Food Chem., Vol. 61, No. 8, pp. <a href=\"http:\/\/dx.doi.org\/10.1021\/jf3033649\">1841-1849<\/a>, 2013.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Esposito, D., <strong>Rathinasabapathy, Th.<\/strong>, Schmidt, B., Shakarjian, M., Komarnytsky, S., and I. Raskin. Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair and Regeneration, Vol. 21, No. 5, pp. <a href=\"http:\/\/dx.doi.org\/10.1111\/wrr.12075\">688-696<\/a>, 2013.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">R. Graziose, M. H. Grace, <strong>Th. Rathinasabapathy<\/strong>, P. Rojas-Silva, C. Dekock, A. Poulev, M. A. Lila, P. Smith, and I. Raskin. Antiplasmodial activity of cucurbitacin glycosides from <i>Datisca glomerata<\/i> (C. Presl) Baill. Phytochemistry, Vol. 87, pp. <a href=\"http:\/\/dx.doi.org\/10.1016\/j.phytochem.2012.11.025\">78-85<\/a>, March 2013.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Graziose, R., Rojas-Silva, P., <strong>Rathinasabapathy, Th.<\/strong>, Dekock, C., Grace, M. H., Poulev, A., Lila, M. A., Smith, P., and I. Raskin. Antiparasitic compounds from <i>Cornus florida<\/i> L. with activities against <i>Plasmodium falciparum<\/i> and <i>Leishmania tarentolae<\/i>. J. of Ethnopharmacology, Vol. 142, No. 2, pp. <a href=\"http:\/\/dx.doi.org\/10.1016\/j.jep.2012.05.017\">456-461<\/a>, 2012.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Esposito, D., <strong>Rathinasabapathy, Th.<\/strong>, Poulev, A., Komarnytsky, S., Raskin, I. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J. Med. Chem., Vol. 54, No. 12, pp. 4057-4066, 2011<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Graziose, R., <strong>Th. Rathinasabapathy<\/strong>, C. Lategan, A. Poulev, P. J. Smith, M. Grace, M. A. Lila, and I. Raskin. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from <i>Liriodendron tulipifera<\/i> L. J. Ethnopharmacology, Vol. 133, No. 1, pp. 26-30, 2011.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">D. Sriram, P. Yogeeswari, M. Dinakaran, <strong>R. Thirumurugan<\/strong>. Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3 (sub) phenyl \/ pyridyl thiourea compounds endowed with high activity toward multidrug-resistant <i>Mycobacterium tuberculosis<\/i>. J. Antimicrobial Chemother., Vol. 59, pp. 1194-1196, 2007.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">D. Sriram, P. Yogeeswari, <strong>R. Thirumurugan<\/strong>, P. Roheeth Kumar. Discovery of newer antitubercular oxazolyl thiosemicarbazones. J. Med. Chem., 49, 3448 &#8211; 3450, 2006.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>R. Thirumurugan<\/strong>, D. Sriram, J. P. Stables, A. Saxena, P. Yogeeswari. 2,4-Dimethoxyphenyl semicarbazones with anticonvulsant activity against three animal models of seizure, synthesis and pharmacological evaluation. Bioorg. Med. Chem., 14, 3106 &#8211; 3112, 2006.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, J. V. Raghavendran, <strong>R. Thirumurugan<\/strong>, S. Induja, J. P. Stables. Synthesis and structure-activity relationship on anticonvulsant arylsemicarbazones. Med. Chem., 2, 55 &#8211; 62, 2006.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, <strong>R. Thirumurugan<\/strong>, D. Sriram, L. R. J. Sunil Jit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J. P. Stables. Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA-mediated mechanism. Acta Pharm., 56, 259 &#8211; 272, 2006.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, <strong>R. Thirumurugan<\/strong>, T. R. Bal. Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: An Uptate. Nat. Prod. Res., 20, 497 &#8211; 505, 2006.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, <strong>R. Thirumurugan<\/strong>, J. V. Raghavendran, K. Sudhan, J. P. Stables. Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants effective against various animal models of seizure with GABA-T inhibitory activity. J. Med. Chem., 48, 6202 &#8211; 6211, 2005.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, V. Veena, R. Kavya, K. Rakhra, S. Mehta, J. Vaigunda Ragavendran, <strong>R. Thirumurugan<\/strong>, J. P. Stables. Synthesis of novel aryl semicarbazones as potential anticonvulsant agents. Biomed. Pharmacother., 59, 51 &#8211; 55, 2005.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">D. Sriram, P. Yogeeswari, <strong>R. Thirumurugan<\/strong>, T. R. Bal. Camptothecin and its Analogues : A review on their chemotherapeutic potential. Nat. Prod. Res., 19, 393 &#8211; 412, 2005.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, <strong>R. Thirumurugan<\/strong>, R. Kavya, S. Samuel, J. P. Stables. 3-Chloro-2-methyl phenyl semicarbazones; synthesis and anticonvulsant activity. Eur. J. Med. Chem., 39, 729 &#8211; 734, 2004.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">D. Sriram, P. Yogeeswari, <strong>R. Thirumurugan<\/strong>. Antituberculous activity of some aryl semicarbazone derivatives. Bioorg. Med. Chem. Lett., 14, 3923 &#8211; 3924, 2004.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, J. Vaigunda Raghavendran, <strong>R. Thirumurugan<\/strong>, A. Saxena, D. Sriram. Ion channels as important targets for antiepileptic drug design. Curr. Drug Targets, 5, 589 &#8211; 602, 2004.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, V. Saraswat, J. Vaigunda Raghavendran, M. Mohan Kumar, S. Murugesan, <strong>R. Thirumurugan<\/strong>, J. P. Stables. Synthesis and anticonvulsant and neurotoxicity evaluation of N4 &#8211; phthalimido phenyl (thio) semicarbazides. Eur. J. Pharm. Sci., 20, 341 &#8211; 346, 2003.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">P. Yogeeswari, D. Sriram, A. Brahmandam, I. Sridharan, <strong>R. Thirumurugan<\/strong>, J. P. Stables. Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism. Med. Chem. Res., 12, 57 &#8211; 68, 2003.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>R. Thirumurugan<\/strong>, S. Kavimai, R. S. Srivastava. Anti-tumour activity of Rhinacanthone against Dalton&#8217;s Ascitic Lymphoma, Biol. Pharm. Bull., 23(12), 1438 &#8211; 1440, 2000.<\/li>\n<\/ol>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Abstracts<\/strong><\/h2>\n<ol><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Graziose, R., Grace, M. H., <strong>Rathinasabapathy, Th.<\/strong>, Rojas-Silva, P., Dekock, C.,Poulev, A., Lila, M. A., Smith, P. J., and I. Raskin. New cucurbitacin glycosides from <i>Datisca glomerata<\/i> with antiplasmodial and cytotoxic activities. Poster presentation at the International Congress on Natural Products Research (ICNPR), July 28 &#8211; August 1, New York, NY, 2012.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>R. Thirumurugan<\/strong>, D. Sriram, P. Yogeeswari. Design and synthesis of novel aryl semicarbazone derivatives as anticonvulsants with GABA and glycine mediated mechanism. International symposium on drug discovery and process research, Shivaji University, Kolhapur &#8211; 416004, January 23 &#8211; 25, 2003.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">J. Vaigunda Ragavendran, <strong>R. Thirumurugan<\/strong>, I. Sridharan, D. Sriram, P. Yogeeswari. 4-Amino butyrate amino transferase (GABA-T) inhibition as a possible mechanism of some novel anticonvulsant aryl semicarbazones. 55<sup>th<\/sup> Indian Pharmaceutical Congress, Chennai, December, 19 &#8211; 21, 2003.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">R. Kavya, <strong>R. Thirumurugan<\/strong>, D. Sriram, P. Yogeeswari. Pharmacological evaluation of aryl(heteroaryl) semi(thio)carbazones for CNS activity. 55<sup>th<\/sup> Indian Pharmaceutical Congress, Chennai, December 19 &#8211; 21, 2003.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">I. Sridharan, B. Archana, <strong>R. Thirumurugan<\/strong>, P. Yogeeswari, D. Sriram. &#947;-aminobutyric acid (GABA) level studies on novel anticonvulsant compounds in rat brain tissue preparation. 54<sup>th<\/sup> Indian Pharmaceutical Congress, Pune, December 13 &#8211; 15, 2002.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">K. Jyothi Mallika, <strong>R. Thirumurugan<\/strong>, N. S. Chakravarthy, P. Yogeeswari, D. Sriram. Tetrahydro-2H-1,3,5-thiadiazine-5-(4-Pyridyl carboxamide)-2-thione derivatives as prodrugs for isoniazid: synthesis and antituberculous activity. 54<sup>th<\/sup> Indian Pharmaceutical Congress, Pune, December, 13 &#8211; 15, 2002.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Education Ph. D. 2005 Medicinal Chemistry, BITS, Pilani, India. M. Pharm. 2000 Pharmaceutical Chemistry, BHU, Varanasy, India. B. Pharm. 1997 Pharmaceutical Sciences, Madurai Medical College, Tamil Nadu, India. Research Experience &hellip; <a href=\"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/thirumurugan-rathinasabapathy\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":82,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1079","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Thirumurugan Rathinasabapathy, Postdoctoral Associate - Ilya Raskin&#039;s Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/thirumurugan-rathinasabapathy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thirumurugan Rathinasabapathy, Postdoctoral Associate - Ilya Raskin&#039;s Laboratory\" \/>\n<meta property=\"og:description\" content=\"Education Ph. 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D. 2005 Medicinal Chemistry, BITS, Pilani, India. M. Pharm. 2000 Pharmaceutical Chemistry, BHU, Varanasy, India. B. Pharm. 1997 Pharmaceutical Sciences, Madurai Medical College, Tamil Nadu, India. 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