{"id":1191,"date":"2019-11-09T21:41:46","date_gmt":"2019-11-09T21:41:46","guid":{"rendered":"http:\/\/sites.rutgers.edu\/ilya-raskin-lab\/?page_id=1191"},"modified":"2019-11-09T21:47:04","modified_gmt":"2019-11-09T21:47:04","slug":"caren-villano","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/caren-villano\/","title":{"rendered":"Caren Villano, Phytomedics Senior Scientist"},"content":{"rendered":"<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Current Work<\/strong><\/h2>\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">My current project involves the development of zebrafish models for screening of botanical compounds for biological activity.  The main focuses of this project include glucose metabolism, appetite suppression, angiogenesis, and wound repair. We are in the process of developing a transgenic zebrafish expressing PEPCK-GFP for faster screening of potential targets of glucose metabolism.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Education<\/strong><\/h2>\n<p><\/p>\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>2003-2007<\/strong> <u>Ph. D<\/u>. \/ Joint Graduate Program in Toxicology; Rutgers University, New Brunswick, NJ.\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Thesis: The effect of all-trans retinoic acid on the inhibitor of DNA binding (Id) family of proteins in cell cycle and development.<\/li>\n<\/ul>\n<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>1999-2001<\/strong> <u>M. S<\/u>. \/ Biology; New York University, New York, NY.\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Thesis: A phylogenetic study of the order Malpighiales using phytochrome C sequencing.<\/li>\n<\/ul>\n<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>1995-1999<\/strong> <u>B. S<\/u>. with Distinction \/ Biotechnology; Worcester Polytechnic Institute, Worcester, MA.\n<ul><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Thesis: TGF-&#946; signaling in A549 lung carcinoma cells.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 style=\"font-family:Trebuchet MS;font-size: 2rem\"><strong>Publications<\/strong><\/h2>\n<ol>\n<\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Rojo, L. E., <strong>Villano, C. M.<\/strong>, Joseph, G., Schmidt, B., Shulaev, V., Shuman, J. L., Lila, M. A., and I. Raskin. Wound-healing properties of nut oil from <i>Pouteria lucuma<\/i>. J Cosmet Dermatol., Vol. 9, No. 3, pp. <a href=\"http:\/\/dx.doi.org\/10.1111\/j.1473-2165.2010.00509.x\">185-195<\/a>, 2010.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Hillegass, J. M., <strong>Villano, C. M.<\/strong>, Cooper, K. R., White, L. A. Glucocorticoids alter craniofacial development and increase expression and activity of matrix metalloproteinases in developing zebrafish (<i>Danio rerio<\/i>). Toxicological Sciences, Vol. 102, No. 2, pp. <a href=\"http:\/\/dx.doi.org\/10.1093\/toxsci\/kfn010\">413-424<\/a>, 2008.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Hillegass, J., <strong>Villano, C. M.<\/strong>, Cooper, K., White, L. A., 2007. Matrix metalloproteinase-13 (MMP-13) is required for zebrafish development and is a target for glucocorticoids. Tox. Sci. 100: 168-179.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Akintobi, A. M., <strong>Villano, C. M.<\/strong>, White, L. A., 2007. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression. Tox. Applied Pharm. 220: 9-17.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Elo, B., Govorko, D., <strong>Villano, C. M.<\/strong>, White, L. A., 2007. Larval zebrafish as a model for glucose metabolism: expression of phophoenolpyruvate carboxykinase (PEPck) as a marker for exposure to anti-diabetic compounds.  J. Mol. Endocrinology. 38: 433-440.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Hillegass, J. M., Murphy, K. A., <strong>Villano, C. M.<\/strong>, and White, L. A., 2006. The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Biol. Chem. 387: 1159-1173.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>Villano, C. M<\/strong>., and White, L. A., 2006. The Aryl Hydrocarbon Receptor-Signaling Pathway and Tissue Remodeling: Insights from the Zebrafish (Danio rerio) Model System. Tox. Sci. 92: 1-4.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>Villano, C. M.<\/strong>, and White, L. A., 2006. Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (Id-1) is activated by all-trans retinoic acid in normal human keratinocytes. Tox. Applied Pharm. 214: 219-229.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\"><strong>Villano, C. M.<\/strong>, Murphy, K. A., Akintobi, A., White, L. A., 2006. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces matrix metalloproteinase (MMP) expression and invasion in A2058 melanoma cells. Tox. Applied Pharm. 210: 212-224.<\/li>\n<p><\/p>\n<li style=\"font-family:Trebuchet MS;font-size: 1rem\">Murphy, K. A., <strong>Villano, C. M.<\/strong>, Dorn, R., and White, L. A., 2004. Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J. Biol. Chem. 279: 25284-25293.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Current Work My current project involves the development of zebrafish models for screening of botanical compounds for biological activity. The main focuses of this project include glucose metabolism, appetite suppression, &hellip; <a href=\"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/caren-villano\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":82,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1191","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Caren Villano, Phytomedics Senior Scientist - Ilya Raskin&#039;s Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/ilya-raskin-lab\/caren-villano\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Caren Villano, Phytomedics Senior Scientist - Ilya Raskin&#039;s Laboratory\" \/>\n<meta property=\"og:description\" content=\"Current Work My current project involves the development of zebrafish models for screening of botanical compounds for biological activity. 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