<\/p>\n
Jacinto, E. Making sense of fat in cancer, Science 2025<\/b>; 387(6739): 1147-1148. PMID: 40080596.<\/p>\n
Werlen, G., Hernandez, T. and Jacinto, E.<\/strong> Food for thought: Nutrient metabolism controlling early T cell development. Bioessays 2024<\/strong><\/a> PMID: 39504233<\/p>\n Chi, O.Z., Liu, X., Fortus, H., Werlen, G.,Jacinto, E<\/b>., and Weiss, H.R. Inhibition of p70 ribosomal S6 kinase (S6K1) reduces cortical blood flow in a rat model of autism-tuberous sclerosis.Neuromol. Med. 2024<\/b>, 4:26(1):10<\/a>, PMID: 3857042<\/p>\n Ragupathi, A., Kim, C., and Jacinto, E<\/strong>. The mTORC2 signaling network: targets and cross-talks, Biochem. J.<\/strong> 2024, 481: 45-91<\/a>. PMID: 38270460<\/p>\n <\/p>\n Jacinto, E.<\/strong> mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination, Cell Metab<\/strong> 2023, 35(12):2097-2099. PMID: 38056426<\/a><\/p>\n <\/p>\n Patel, N. and Jacinto, E<\/strong>. The mTOR complexes: Coordinating metabolism and translation, RNA-based Mechanisms in Cancer<\/strong>, pp243-302 (2023<\/a>), World Scientific<\/p>\n <\/p>\n Paneque, A., Fortus, H., Zheng, J., Werlen, G., and Jacinto, E<\/strong>. The hexosamine biosynthesis pathway: regulation and function, Genes<\/strong> 2023, 14(4),933<\/a>.<\/p>\n <\/p>\n Werlen, G., Li, M.L., Tottone, L., da Silva-Diz, V., Su, X., Herranz, D., and Jacinto, E<\/strong>. Dietary glucosamine overcomes the defects in alpha\/beta-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis, Nature Comm<\/strong>. 2022, 13, 7404<\/a><\/p>\n <\/p>\n Li, M.L., Ragupathi, A., Patel, N., Hernandez, T., Magsino, J., Werlen, G., Brewer, G. and Jacinto, E<\/strong>. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. J. Biol. Chem. 2022<\/strong> 298(10):102437. PMID: 36041631<\/a><\/p>\n <\/p>\n Werlen, G., Jain, R. and Jacinto, E<\/strong>. mTOR signaling and metabolism in early T cell development. Genes 2021<\/strong>, 12, 728<\/a>.<\/p>\n <\/p>\n Szwed, A., Kim, E. and Jacinto, E<\/strong>. Regulation and metabolic functions of mTORC1 and mTORC2., Physiol. Rev. 2021<\/strong>, 101(3):1371-1426 PMID: 33599151<\/a><\/p>\n <\/p>\n Chi, O.Z., Chiricolo, A. Liu, X., Patel, N., Jacinto E<\/strong>., and Weiss, H.R. Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption. Neurosci. Lett 2021<\/strong>, 762:136143, PMID: 34332027<\/a><\/p>\n <\/p>\n Chi, O.Z., Liu, X., Cofano, S., Patel, N., Jacinto, E.<\/strong>, and Weiss, H.R. Rapalink-1 increased infarct size in early cerebral ischemia-reperfusion with increased blood-brain barrier disruption. Front. Phys. 2021<\/strong>, 12:706528, doi: 10.3389\/fphys.2021.706528.<\/a><\/p>\n <\/p>\n Ye, C., Liu, B., Lu, H., Liu, J., Rabson, A.B., Jacinto, E<\/strong>., Pestov, D.G., and Shen, Z. BCCIP is required for nucleolar recruitment of eIF6 and 12s pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020<\/strong>, 48(22):12817-12832 PMID: 33245766<\/a><\/p>\n <\/p>\n Chi, O.Z., Mellender, S.J., Kiss, G.K., Chiricolo, A., Liu, X., Patel, N., Jacinto, E<\/strong>., and Weiss, H.R. Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability. J. Stroke Cerebrovasc Dis. 2020<\/strong>, 29(10):105029 PMID: 32912542<\/a><\/p>\n <\/p>\n Chou, P.C., Rajput, S., Zhao, X., Patel, C., Albaciete, D., Oh, W.J., Daguplo, H.Q., Patel, N., Su,, B., Werlen, G., and Jacinto, E<\/strong>. mTORC2 is involved in the induction of RSK phosphorylation by serum or nutrient starvation. Cells 2020<\/strong>, 9(7):E1567, PMID:32605013<\/a><\/p>\n <\/p>\n La Manna, F., De Menna, M., Patel, N., Karkampouna, S., De Filippo, M., Klima, I., Kloen, P., Beimers, L., Thalmann, G.N., Pelger, R.C.M., Jacinto, E.,<\/strong> and Kruithof-de Julio, M. Dual mTOR inhibitor Rapalink-1 reduces prostate cancer patient-derived xenograft growth and alters tumor heterogeneity. Front. Onc. 2020<\/strong>, 10:1012. PMID:32656088<\/a><\/p>\n <\/p>\n Cordover, E., Wei, J., Patel, C., Shen, N.L., Gionco, J., Sargsyan, D., Wu, R., Cai, L., Kong, A.T., Jacinto, E<\/strong>, and Minden, A. KPT_9274, an inhibitor of PAK4 and NAMPT, leads to downregulation of mTORC2 in triple negative breast cancer cells. Chem. Res. Toxicol. 2019<\/strong>, PMID: 31876149<\/a><\/p>\n <\/p>\n Magaway, C., Kim, E., and Jacinto, E.<\/strong> Targeting mTOR and metabolism in cancer:\u00a0 Lessons and Innovations. \u00a0Cells<\/a><\/strong> 2019<\/strong>, 8(12). Pii:E1584. PMID: 31817676<\/p>\n <\/p>\n Jacinto, E.<\/strong>\u00a0 The young and the restless: Isolating the dynamic mammalian pre-ribosomes, J. Biol. Chem<\/strong>., 2019<\/strong>, 294(28): 10758-10759. PMID 31300590.<\/a><\/p>\n <\/p>\n Jacinto, E<\/strong>.\u00a0 Amplifying mTORC2 signals through AMPK during energy stress., Science Sig<\/strong>. 2019<\/strong>, 12(585). PMID 31186374<\/a><\/p>\n <\/p>\n Chi, O.Z., Kiss, G.K., Mellender, S.J., Liu, X., Liu, S., Jacinto, E<\/strong>., and Weiss, H. Inhibition of p70 ribosomal S6 kinase (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability. Eur. J. Pharmacol. 2019<\/strong>, 855:202-207. PMID:31063769<\/a><\/p>\n <\/p>\n Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E<\/strong>. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation.\u00a0 J. Biol Chem. 2018<\/strong>, 293(42): 16464-16478, PMID 30201609<\/a><\/p>\n <\/p>\n Weiss, H.R., Chi, O.Z., Kiss, G.K., Liu, X., Damito, S., and Jacinto E<\/strong>., Akt activation improves microregional oxygen supply\/consumption balance after cerebral ischemia-reperfusion. Brain Res. 2018<\/strong> 1683:48-54. PMID 29371097<\/a><\/p>\n <\/p>\n Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, Wu, C., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E<\/strong>. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Molecular Cell 2016, <\/strong>63, 811-826. PMID:27570073<\/a><\/p>\n <\/p>\n Chi, O.Z., Barsoum, S., Vega-Cotto, N.M., Jacinto, E<\/strong>., Liu X., Mellender, S.J., and Weiss, H.R. Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia, Neuroscience 2016<\/strong> 316:321-7. PMID 26742793<\/a><\/p>\n <\/p>\n Tobias, I., Kaulich, M., Kim, P.K., Simon, N., Jacinto, E<\/strong>., Dowdy, S., King, C.C., and Newton, AC. Protein kinase C z exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation, Biochem J 2016<\/strong>, 473(4):509-23.\u00a0 PMID: 26635352<\/a><\/p>\n <\/p>\n Lynch, T., Moloughney, J., and Jacinto, E<\/strong>. The mTOR complexes in cancer cell metabolism., in PI3K-mTOR in cancer and cancer therapy 2016<\/strong>, Springer,\u00a0 p. 29-63, ed. B. Leyland Jones, P. De, N. Dey,.<\/a><\/p>\n <\/p>\n Jacinto, E<\/strong>. and Werlen, G. mTOR: The mTOR complexes in T cell development and immunity, in Encyclopedia of Inflammatory Diseases 2015<\/strong>, ed. M.J. Parnham, Springer.<\/a><\/p>\n <\/p>\n Chi, O.Z., Wu, C.C., Liu, X., Rah, K.H., Jacinto, E<\/strong>., and Weiss, H.R., Restoration of cerebral oxygen consumption with rapamycin treatment in a rat model of autism-tuberous sclerosis, Neuromolecular Medicine 2015<\/strong>, 17(3):305-13. PMID: 26048361<\/a><\/p>\n <\/p>\n Chou, P.C., Moloughney, J., Oh, W.J., Wu, C.C., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E.*<\/strong> and Werlen, G.* mTORC2 modulates alpha\/beta T cell receptor processing and surface expression during thymocyte development., J. Immunol. 2014<\/strong>,\u00a0 193, 1162-1170.\u00a0 PMID: 24981454<\/a> *co-corresponding authors<\/p>\n <\/p>\n DeStefano, M.A. and Jacinto, E<\/strong>. Regulation of insulin receptor substrate-1 by mTORC2. Biochem. Soc. Trans<\/strong>. 2013<\/strong>;\u00a0 41, 896-901. PMID: 23142081<\/a><\/p>\n <\/p>\n Kim, S.J*., DeStefano, M.A.*, Oh, W.J., Wu, C., Vega-Cotto, N.M., Finlan, M., Liu, D., Su, B., and Jacinto, E<\/strong>. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase Fbw8.\u00a0 Molecular Cell 2012; <\/strong>48, 875-887.\u00a0 <\/strong>PMID: 23142081<\/a><\/p>\n <\/p>\n Wu, C., Chou, P., and Jacinto, E<\/strong>.\u00a0 The target of rapamycin; structure and functions, in Protein Kinases 2012<\/strong>, Intech Publishing, p1-40, ed. Xavier, G.<\/a><\/p>\n <\/p>\n Su, B., and Jacinto, E<\/strong>.\u00a0 mTOR signaling to the AGC kinases.\u00a0 Crit. Rev. in Biochem. and Molec. Biol. 2011<\/strong>, 46, 527-547.<\/a><\/p>\n <\/p>\n Jacinto, E<\/strong>.\u00a0 TFEBulous control of traffic by mTOR.\u00a0 EMBO J<\/strong>. 2011<\/strong>, 30, 3215-3216<\/a><\/p>\n <\/p>\n Oh, W., and Jacinto, E<\/strong>.\u00a0 mTOR complex 2 signaling and functions.\u00a0 Cell Cycle 2011<\/strong>; 10, 1-12. PMID: 21670596<\/a><\/p>\n <\/p>\n Oh, W*., Wu, C.*, Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., and Jacinto, E<\/strong>. mTORC2 associates with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010; <\/em><\/strong>29, 3939-3951. PMID: 21045808<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong>\u00a0 AGC kinases in mTOR signaling.\u00a0 Ed. M. Hall and F. Tamanoi: The Enzymes 2010<\/strong>; 27, 101-128. Burlington: Academic Press.\u00a0 PMID: 18215152<\/a><\/p>\n <\/p>\n Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A.C., Mao, Y., Miao, R.Q., Sessa, W.C., Qin, J., Zhang, P., Su, B., and Jacinto, E.<\/strong> The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008; <\/strong>27, 1932-1943. PMID: 18566586<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong>, and Lorberg, A.\u00a0 TOR regulation of AGC kinases in yeast and mammals.\u00a0\u00a0 Biochem. J. 2008;<\/strong> 410, 19-37.\u00a0 PMID:18215152<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong>\u00a0 What controls TOR?\u00a0 IUBMB Life 2008;<\/strong> 60, 483-96.\u00a0 PMID: 18493947<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong> *, Facchinetti*, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., and Su, B. SIN1\/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006<\/strong>; 127, 125-137. PMID: 16962653<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong> Phosphatase targets in TOR signaling.\u00a0 Ed. G. Moorhead, Methods Mol. Biol 2006;<\/strong> 365, 323-334.\u00a0 Humana Press Inc., Totowa, NJ.\u00a0 PMID: 17200572<\/a><\/p>\n <\/p>\n Jacinto, E.*<\/strong>, Loewith, R.*, Schmidt, A., Lin, S., Ruegg, M., Hall, A., and Hall, M.N. Mammalian TOR complex 2 (mTORC2) controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology 2004;<\/strong> 6, 1122-1128. \u00a0PMID: 15467718<\/a> *equal contribution<\/p>\n <\/p>\n Jacinto, E.<\/strong>, and Hall, M.N.\u00a0 TOR signaling in bugs, brain, and brawn.\u00a0 Nature Reviews (Mol. Cell. Biol.) 2003;<\/strong> 4, 117-126. PMID: 12563289<\/a><\/p>\n <\/p>\n Bonenfant, D., Schmelzle, T., Jacinto, E.<\/strong>, Crespo, J.L., Mini, T., Hall, M.N., and Jenoe, P. Quantitation of changes in site specific phosphorylation: a simple method based on stable isotope labelling and mass spectrometry. Proc. Natl. Acad. Sci. 2003; <\/strong>100, 880-885. PMID: 12540831<\/a><\/p>\n <\/p>\n Loewith, R., Jacinto, E.<\/strong>, Wullschleger, S., Lorberg, A., Crespo, J.L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell 2002<\/strong>; 10, 457-468. PMID:12408816<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong>, Guo, B., Arndt, K.T., Schmelzle, T., and Hall, M.N. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Molecular Cell 2001; <\/strong>\u00a08, 1017-1026. PMID: 11741537<\/a><\/p>\n <\/p>\n Werlen, G., Jacinto, E.<\/strong>, Xia, Y., and Karin, M. Calcineurin preferentially synergizes with PKC-theta to activate JNK in T lymphocytes. EMBO J 1998;<\/strong> 17, 3101-3111. PMID: 9606192<\/a><\/p>\n <\/p>\n Jacinto, E.<\/strong>, Werlen, G., and Karin, M. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 1998; <\/strong>\u00a08, 31-41. PMID: 9462509<\/a><\/p>\n <\/p>\n Wu, Z., Wu, J., Jacinto, E.<\/strong>, and Karin, M. Molecular cloning and characterization of human JNKK2, a novel Jun N-terminal kinase (JNK)-specific kinase. Mol. Cell. Biol 1997; <\/strong>\u00a017, 7407-7416. PMID: 9372971<\/a><\/p>\n <\/p>\n Su, B., Jacinto, E.<\/strong>, Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994;<\/strong> 77, 727-736. PMID: 8205621<\/a><\/p>\n <\/p>\n Jacinto, E<\/strong>. Signal integration in T lymphocytes: The role of JNK and ERK. Dissertation (UCSD) 1997<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"