{"id":994,"date":"2023-04-19T20:03:27","date_gmt":"2023-04-19T20:03:27","guid":{"rendered":"https:\/\/sites.rutgers.edu\/jacinto-lab\/?page_id=994"},"modified":"2023-04-19T20:03:27","modified_gmt":"2023-04-19T20:03:27","slug":"chang-chih-wu","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/jacinto-lab\/chang-chih-wu\/","title":{"rendered":"Chang-chih Wu"},"content":{"rendered":"<p><strong>Publications:<\/strong><\/p>\n<p>Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., <strong>Wu, C<\/strong>., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation.\u00a0 <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(20)35111-5\/fulltext\"><strong>J. Biol Chem. 2018<\/strong>, 293(42): 16464-16478, PMID 30201609<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, <strong>Wu, C<\/strong>., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. <a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(16)30368-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276516303689%3Fshowall%3Dtrue\"><strong>Molecular Cell 2016, <\/strong>63, 811-826. PMID:27570073<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Chi, O.Z., <strong>Wu, C.C<\/strong>., Liu, X., Rah, K.H., Jacinto, E., and Weiss, H.R., Restoration of cerebral oxygen consumption with rapamycin treatment in a rat model of autism-tuberous sclerosis, <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12017-015-8359-5\"><strong>Neuromolecular Medicine 2015<\/strong>, 17(3):305-13. PMID: 26048361<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Chou, P.C., Moloughney, J., Oh, W.J., <strong>Wu, C.C<\/strong>., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E<strong>.*<\/strong> and Werlen, G.* mTORC2 modulates alpha\/beta T cell receptor processing and surface expression during thymocyte development., <a href=\"https:\/\/journals.aai.org\/jimmunol\/article\/193\/3\/1162\/108995\/Mammalian-Target-of-Rapamycin-Complex-2-Modulates\"><strong>J. Immunol. 2014<\/strong>,\u00a0 193, 1162-1170.\u00a0 PMID: 24981454<\/a> *co-corresponding authors<\/p>\n<p>&nbsp;<\/p>\n<p>Kim, S.J*., DeStefano, M.A.*, Oh, W.J., <strong>Wu, C<\/strong>., Vega-Cotto, N.M., Finlan, M., Liu, D., Su, B., and Jacinto, E. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase Fbw8.\u00a0 <a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(12)00852-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276512008520%3Fshowall%3Dtrue\"><strong>Molecular Cell 2012; <\/strong>48, 875-887<strong>.\u00a0 <\/strong>PMID: 23142081<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Wu, C<\/strong>., Chou, P., and Jacinto, E.\u00a0 The target of rapamycin; structure and functions, in <a href=\"https:\/\/www.rwjms.rutgers.edu\/documents\/labs\/jacinto-lab\/InTechBookChapter2012.pdf\"><strong>Protein Kinases 2012<\/strong>, Intech Publishing, p1-40, ed. Xavier, G.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Oh, W*., <strong>Wu, C<\/strong>.*, Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., and Jacinto, E. mTORC2 associates with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/emboj.2010.271\"><strong>EMBO J. 2010<em>; <\/em><\/strong>29, 3939-3951. PMID: 21045808<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications: Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates &hellip; <a href=\"https:\/\/sites.rutgers.edu\/jacinto-lab\/chang-chih-wu\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":1728,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-994","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chang-chih Wu - Jacinto Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/jacinto-lab\/chang-chih-wu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chang-chih Wu - Jacinto Lab\" \/>\n<meta property=\"og:description\" content=\"Publications: Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates &hellip; 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