Lab News
01/13/2024
Design of the first-in-class SARS-CoV-2 papain-like protease inhibitors with in vivo antiviral efficacy in a mouse model
https://www.biorxiv.org/content/10.1101/2023.12.01.569653v1
https://www.rutgers.edu/news/rutgers-racing-develop-paxlovid-replacement
03/13/2023
Welcome Yvonne Wen, who joined us as a Research Assistant Professor!
08/29-08/30/2022
We are glad to share our results of SARS-CoV-2 main protease drug resistant mutants on the World Health Organization meeting Scientific Strategies From Recent Outbreaks To Help Us Prepare For Pathogen X.
07/26/2022
China approves first homegrown COVID antiviral
06/29/2022
Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug
07/05/2022
Some Pre-existing Mutant Strains of the Virus Causing COVID-19 May Resist Paxlovid
05/27/2022
Coronavirus hasn’t developed resistance to Paxlovid. How long can that last?
Coronavirus hasn’t developed resistance to Paxlovid. How long can that last?
05/26/2022
新冠口服药对奥密克戎仍有效，但需警惕抗药性 (Paxlovid remains effective against Omicron variant, but be cautious)
05/10/2022
Paxlovid update
https://www.science.org/content/blog-post/paxlovid-update
04/07/2022
Research at Ernest Mario School of Pharmacy finds that antiviral drug can treat coronavirus
03/18/2022
How Omicron is Challenging China’s Grip on COVID-19
https://www.sixthtone.com/news/1009927/how-omicron-is-challenging-chinas-grip-on-covid-19
03/17/2022
Our study of the SARS-CoV-2 Mpro mutant was highlighted in Rutgers Today!
03/10/2022
Study joins search for variant-proof approach to SARS-CoV-2 treatment.
12/1/2021
COVID-19 antiviral drugs (SciLine)
Pfizer: Partnerships and anti-infective efforts
https://www.pfizer.com/science/coronavirus/partnerships
04/22/2021
Our paper on the rational design of non-covalent SARS-CoV-2 main protease inhibitors was published in
J. Med. Chem. The non-covalent Mpro inhibitors are highly selective against host cysteine proteases, while the canonical Mpro inhibitors such as GC376 were not selective and inhibited a number of host proteases. The most potent compound 23R occupies a new pocket in Mpro that has not been explored before.
02/25/2021
In a following up study, we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against MERS-CoV, SARS-CoV, HCoV-OC43, HCoV-NL63, and HCoV-229E in addition to SARS-CoV-2. More importantly, all four compounds also had potent antiviral activity against SARS-CoV-2 in TMPRSS2-expressing Caco2 cells. Check our recent publication in ACS Infect. Dis.
02/09/2021
Our paper entitled “The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor” was accepted by Emerging Microbes and Infections. In this study, we have shown the lactoferrin, a natural protein that is abundant in milk, inhibits multiple coronaviruses including SARS-CoV-2 by preventing the binding of the virus to the host heparan sulfate attachment factor. Check this paper at www.tandfonline.com/doi/full/10.1080/22221751.2021.1888660
1/21/2021
Our letter to the editor entitled “Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors” was accepted by
Proc. Natl. Acad. Sci. U S A. In this communication, we provided experimental evidence to invalidate the previous reported SARS-CoV-2 main protease inhibitor in this paper www.pnas.org/content/117/44/27381
11/6/2020
Our Science Advances paper is online! Check it out!
https://advances.sciencemag.org/content/early/2020/11/05/sciadv.abe0751
11/5/2020
Dr. Wang is honored to be elected as the editorial board member of the European Journal of Pharmaceutical Sciences, which he has reviewed more than 80 manuscripts so far! Check it out:
www.journals.elsevier.com/european-journal-of-pharmaceutical-sciences/editorial-board
11/1/2020
In this preprint we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 not only inhibits SARS-CoV-2, but also SARS-CoV, MERS-CoV, and seasonal human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43.
https://www.biorxiv.org/content/10.1101/2020.10.30.362335v1
Check out the news coverage of this study at News Medical Life Sciences.
Discovery of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376
10/14/2020
Our manuscript entitled “Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L” was accepted by Science Advances. Thanks to our collaborators Dr. Yu Chen (USF), Dr. Michael Marty (UA), Dr. Yan Xiang (UTSA), Dr. Brett Hurst and Dr. Bart Tarbet (USU) for their contribution!