{"id":543,"date":"2021-11-28T21:01:09","date_gmt":"2021-11-28T21:01:09","guid":{"rendered":"https:\/\/sites.rutgers.edu\/jun-wang-lab\/?page_id=543"},"modified":"2024-01-13T19:28:29","modified_gmt":"2024-01-13T19:28:29","slug":"lab-news-2","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/jun-wang-lab\/lab-news-2\/","title":{"rendered":"Lab News"},"content":{"rendered":"<p>01\/13\/2024<\/p>\n<p>Design of the first-in-class SARS-CoV-2 papain-like protease inhibitors with in vivo antiviral efficacy in a mouse model<\/p>\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.01.569653v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.01.569653v1<\/a><\/p>\n<p><a href=\"https:\/\/www.rutgers.edu\/news\/rutgers-racing-develop-paxlovid-replacement\">https:\/\/www.rutgers.edu\/news\/rutgers-racing-develop-paxlovid-replacement<\/a><\/p>\n<p>03\/13\/2023<\/p>\n<p>Welcome Yvonne Wen, who joined us as a Research Assistant Professor!<\/p>\n<p>08\/29-08\/30\/2022<\/p>\n<p>We are glad to share our results of SARS-CoV-2 main protease drug resistant mutants on the World Health Organization meeting <a href=\"https:\/\/www.who.int\/news-room\/events\/detail\/2022\/08\/29\/default-calendar\/save-the-date---scientific-strategies-from-recent-outbreaks-to-help-us-prepare-for-pathogen-x\">Scientific Strategies From Recent Outbreaks To Help Us Prepare For Pathogen X<\/a>.<\/p>\n<p>07\/26\/2022<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/d41586-022-02050-x\">China approves first homegrown COVID antiviral<\/a><\/p>\n<p>06\/29\/2022<\/p>\n<p><a href=\"https:\/\/www.science.org\/content\/article\/bad-news-paxlovid-coronavirus-can-find-multiple-ways-evade-covid-19-drug\">Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug<\/a><\/p>\n<p>07\/05\/2022<\/p>\n<p>Some Pre-existing Mutant Strains of the Virus Causing COVID-19 May Resist Paxlovid<\/p>\n<p><a href=\"https:\/\/www.rutgers.edu\/news\/some-pre-existing-mutant-strains-virus-causing-covid-19-may-resist-paxlovid\">https:\/\/www.rutgers.edu\/news\/some-pre-existing-mutant-strains-virus-causing-covid-19-may-resist-paxlovid<\/a><\/p>\n<p>05\/27\/2022<\/p>\n<p>Coronavirus hasn&#8217;t developed resistance to Paxlovid. How long can that last?<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"bVfa1BdCMF\"><p><a href=\"https:\/\/www.statnews.com\/2022\/05\/27\/paxlovid-resistance-covid-antivirals\/\">Coronavirus hasn&#8217;t developed resistance to Paxlovid. How long can that last?<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Coronavirus hasn&#8217;t developed resistance to Paxlovid. How long can that last?&#8221; &#8212; STAT\" src=\"https:\/\/www.statnews.com\/2022\/05\/27\/paxlovid-resistance-covid-antivirals\/embed\/#?secret=goJvbCX9T5#?secret=bVfa1BdCMF\" data-secret=\"bVfa1BdCMF\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>05\/26\/2022<\/p>\n<p class=\"inner_view_title\">\u65b0\u51a0\u53e3\u670d\u836f\u5bf9\u5965\u5bc6\u514b\u620e\u4ecd\u6709\u6548\uff0c\u4f46\u9700\u8b66\u60d5\u6297\u836f\u6027 <a href=\"http:\/\/zhishifenzi.com\/news\/multiple\/12333.html\">(Paxlovid remains effective against Omicron variant, but be cautious)<\/a><\/p>\n<p>05\/10\/2022<\/p>\n<p>Paxlovid update<\/p>\n<p><a href=\"https:\/\/www.science.org\/content\/blog-post\/paxlovid-update\">https:\/\/www.science.org\/content\/blog-post\/paxlovid-update<\/a><\/p>\n<p>04\/07\/2022<\/p>\n<p>Research at Ernest Mario School of Pharmacy finds that antiviral drug can treat coronavirus<\/p>\n<p><a href=\"https:\/\/dailytargum.com\/article\/2022\/04\/research-at-ernest-mario-school-of-pharmacy-finds-that-antiviral-drug-can\">https:\/\/dailytargum.com\/article\/2022\/04\/research-at-ernest-mario-school-of-pharmacy-finds-that-antiviral-drug-can<\/a><\/p>\n<p>03\/18\/2022<\/p>\n<p>How Omicron is Challenging China&#8217;s Grip on COVID-19<\/p>\n<p><a href=\"https:\/\/www.sixthtone.com\/news\/1009927\/how-omicron-is-challenging-chinas-grip-on-covid-19\">https:\/\/www.sixthtone.com\/news\/1009927\/how-omicron-is-challenging-chinas-grip-on-covid-19<\/a><\/p>\n<p>03\/17\/2022<\/p>\n<p>Our study of the SARS-CoV-2 Mpro mutant was highlighted in Rutgers Today!<\/p>\n<p><a href=\"https:\/\/www.rutgers.edu\/news\/key-antiviral-treatment-covid-19-still-effective-despite-resistance-fears\">https:\/\/www.rutgers.edu\/news\/key-antiviral-treatment-covid-19-still-effective-despite-resistance-fears<\/a><\/p>\n<p>03\/10\/2022<\/p>\n<p>Study joins search for variant-proof approach to SARS-CoV-2 treatment.<\/p>\n<p><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/study-joins-search-for-variant-proof-approach-to-sars-cov-2-treatment\">https:\/\/www.medicalnewstoday.com\/articles\/study-joins-search-for-variant-proof-approach-to-sars-cov-2-treatment<\/a><\/p>\n<p>12\/1\/2021<\/p>\n<p>COVID-19 antiviral drugs (SciLine)<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"gLJi1K3yht\"><p><a href=\"https:\/\/www.sciline.org\/covid-19\/quotes-antiviral-molnupiravir-paxlovid\/\">COVID-19 antiviral drugs<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;COVID-19 antiviral drugs&#8221; &#8212; SciLine\" src=\"https:\/\/www.sciline.org\/covid-19\/quotes-antiviral-molnupiravir-paxlovid\/embed\/#?secret=Is8mquZ47C#?secret=gLJi1K3yht\" data-secret=\"gLJi1K3yht\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>Pfizer: Partnerships and anti-infective efforts<\/p>\n<p><a href=\"https:\/\/www.pfizer.com\/science\/coronavirus\/partnerships\">https:\/\/www.pfizer.com\/science\/coronavirus\/partnerships<\/a><\/p>\n<p>04\/22\/2021<br \/>\nOur paper on the rational design of non-covalent SARS-CoV-2 main protease inhibitors was published in<br \/>\n<strong><em>J. Med. Chem.\u00a0<\/em><\/strong>The non-covalent Mpro inhibitors are highly selective against host cysteine proteases, while the canonical Mpro inhibitors such as GC376 were not selective and inhibited a number of host proteases. The most potent compound\u00a0<strong>23R\u00a0<\/strong>occupies a new pocket in Mpro that has not been explored before.<\/p>\n<p>02\/25\/2021<br \/>\nIn a following up study, we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against MERS-CoV, SARS-CoV, HCoV-OC43, HCoV-NL63, and HCoV-229E in addition to SARS-CoV-2. More importantly, all four compounds also had potent antiviral activity against SARS-CoV-2 in TMPRSS2-expressing Caco2 cells. Check our recent publication in\u00a0<strong><em>ACS Infect. Dis.\u00a0<\/em><\/strong><\/p>\n<p>02\/09\/2021<br \/>\nOur paper entitled &#8220;The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor&#8221; was accepted by\u00a0<em><strong>Emerging Microbes and Infections<\/strong><\/em>. In this study, we have shown the lactoferrin, a natural protein that is abundant in milk, inhibits multiple coronaviruses including SARS-CoV-2 by preventing the binding of the virus to the host heparan sulfate attachment factor.\u00a0\u00a0Check this paper at\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/22221751.2021.1888660\">www.tandfonline.com\/doi\/full\/10.1080\/22221751.2021.1888660<\/a><\/p>\n<p>1\/21\/2021<br \/>\nOur letter to the editor entitled &#8220;<strong>Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors&#8221;\u00a0<\/strong>was accepted by<br \/>\n<strong><em>Proc. Natl. Acad. Sci. U S A.\u00a0<\/em><\/strong>In this communication, we provided experimental evidence to invalidate the previous reported SARS-CoV-2 main protease inhibitor in this paper\u00a0<a href=\"https:\/\/www.pnas.org\/content\/117\/44\/27381\">www.pnas.org\/content\/117\/44\/27381<\/a><\/p>\n<p>11\/6\/2020<br \/>\nOur\u00a0<strong><em>Science Advances<\/em><\/strong>\u00a0paper is online! Check it out!<br \/>\nhttps:\/\/<a href=\"https:\/\/advances.sciencemag.org\/content\/early\/2020\/11\/05\/sciadv.abe0751\">advances.sciencemag.org\/content\/early\/2020\/11\/05\/sciadv.abe0751<\/a><\/p>\n<p>11\/5\/2020<br \/>\nDr. Wang is honored to be elected as the editorial board member of the\u00a0<strong><em>European Journal of Pharmaceutical Sciences<\/em><\/strong>, which he has reviewed more than 80 manuscripts so far! Check it out:<br \/>\n<a href=\"https:\/\/www.journals.elsevier.com\/european-journal-of-pharmaceutical-sciences\/editorial-board\">www.journals.elsevier.com\/european-journal-of-pharmaceutical-sciences\/editorial-board<\/a><\/p>\n<p>11\/1\/2020<br \/>\nIn this preprint we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 not only inhibits SARS-CoV-2, but also SARS-CoV, MERS-CoV, and seasonal human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43.<br \/>\nhttps:\/\/<a href=\"http:\/\/www.biorxiv.org\/content\/10.1101\/2020.10.30.362335v1\">www.biorxiv.org\/content\/10.1101\/2020.10.30.362335v1<\/a><br \/>\nCheck out the news coverage of this study at News Medical Life Sciences.<br \/>\n<strong><a href=\"https:\/\/www.news-medical.net\/news\/20201103\/Discoverey-of-four-SARS-CoV-2-Mpro-inhibitors-boceprevir-calpain-inhibitors-II-and-XII-and-GC-376.aspx\">Discovery\u00a0of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376<\/a><\/strong><\/p>\n<p>10\/14\/2020<br \/>\nOur manuscript entitled &#8220;Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L&#8221; was accepted by\u00a0<strong><em>Science Advances.\u00a0<\/em><\/strong>Thanks to our collaborators Dr. Yu Chen (USF), Dr. Michael Marty (UA), Dr. Yan Xiang (UTSA), Dr. Brett Hurst and Dr. Bart Tarbet (USU) for their contribution!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>01\/13\/2024 Design of the first-in-class SARS-CoV-2 papain-like protease inhibitors with in vivo antiviral efficacy in a mouse model https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.01.569653v1 https:\/\/www.rutgers.edu\/news\/rutgers-racing-develop-paxlovid-replacement 03\/13\/2023 Welcome Yvonne Wen, who joined us as a Research &hellip; <a href=\"https:\/\/sites.rutgers.edu\/jun-wang-lab\/lab-news-2\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":2041,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-543","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lab News - Jun Wang Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/jun-wang-lab\/lab-news-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lab News - Jun Wang Lab\" \/>\n<meta property=\"og:description\" content=\"01\/13\/2024 Design of the first-in-class SARS-CoV-2 papain-like protease inhibitors with in vivo antiviral efficacy in a mouse model https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.01.569653v1 https:\/\/www.rutgers.edu\/news\/rutgers-racing-develop-paxlovid-replacement 03\/13\/2023 Welcome Yvonne Wen, who joined us as a Research &hellip; 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