{"id":170,"date":"2017-12-22T18:13:36","date_gmt":"2017-12-22T18:13:36","guid":{"rendered":"http:\/\/sites.rutgers.edu\/professor-example\/?page_id=170"},"modified":"2026-04-17T15:06:04","modified_gmt":"2026-04-17T15:06:04","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/longqin-hu\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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  1. Ahmed Reda Ali, Longqin Hu<\/strong>* N<\/em>-Mesyl-enabled Cu\u2082O catalysis: Synthesis of (E<\/em>)-3-alkylideneisoindolin-1-ones and 3,4-unsubstituted isoquinolones via sequential alkynylation\/annulation. J.<\/em> Org. Chem.<\/em> 2026<\/strong>, 91<\/em>(15), 5402-5411. Full Text: PDF <\/a>\"\"<\/a>
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  2. Sumi Lee, Ahmed R, Ali, Dhulfiqar Ali Abed, Longqin Hu<\/strong>* Discovery of an N<\/em>-phenylglycine-based scaffold as a direct Keap1-Nrf2 PPI inhibitor through a molecular hybridization strategy. J. Enzyme Inhib. Med. Chem.<\/em> 2026<\/strong>, 41<\/em>(1), 2622777 (22 pp). <\/em>Full Text: PDF <\/a>\"\"<\/a>\"\"<\/a><\/em><\/li>\n
  3. Zi Hui, Xiang-Yang Ye, Yuting Zhang, Longqin Hu<\/strong>,* Tian Xie,* Zhao-Qian Liu* Lenacapavir, a first-in-class, long-acting capsid inhibitor approved for both HIV-1 treatment and prevention. Med. Chem. Res.<\/em> 2025<\/strong>, 34<\/em>(12), 2472-2485. Full Text: PDF <\/a>\"\"<\/a>
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  4. Ahmed Reda Ali, Longqin Hu<\/strong>* Cu2<\/sub>O-mediated regio- and stereoselective one-pot synthesis of (Z<\/em>)-3-ylidenephthalides from 2-iodobenzoic acids and terminal alkynes. Org. Biomol. Chem.<\/em> 2025<\/strong>, 23<\/em>(32), 7483-7490. Full Text: PDF<\/a> \"\"<\/a>\"\"<\/a><\/li>\n
  5. Ahmed Reda Ali, Longqin Hu<\/strong>* One-Pot Synthesis of 2-Substituted Indoles and 7-Azaindoles via Sequential Alkynylation and Cyclization of 2-Iodo-N-mesylarylamines and Alkynes in the Presence of Cu2<\/sub>O. Asian J.<\/em> Org. Chem.<\/em> 2025<\/strong>, 14<\/em>(1), e202400421 (7 pp). Full Text: PDF<\/a> \"\"<\/a>
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  6. Longqin Hu<\/strong>,* Akash Taneja, Husam Zahid, Yiling Wang, Min Yang, Zhihua An, Xingsheng Li, Jay Tischfield, John Knight, Michael D. Ward, and Amrik Sahota Discovery of L-lysine dioxalate (LH1513) as a novel inhibitor of calcium oxalate crystallization for hyperoxaluria. ACS Med. Chem. Lett.<\/em> 2024<\/strong>, 15<\/em>(11), 2005-2011. Full Text: PDF;<\/a>\u00a0Correction<\/a>
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  7. Longqin Hu<\/strong>*, Haifa Albanyan, Jeffrey Yang, Xiangduan Tan, Yiling Wang, Min Yang, Xiaodi Zhong, Michael D. Ward, Amrik Sahota Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria. Med. Chem. Res.<\/em> 2024<\/strong>, 33<\/em>(8), 1384 – 1407. Full Text: PDF\u00a0 \u00a0<\/a>\"\"<\/a>
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  8. Longqin Hu*<\/strong>, Haifa Albanyan, Jeffrey Yang, Yiling Wang, Min Yang, Xiangduan Tan, Xiaodi Zhong, Michael Ward, Amrik Sahota 8-L-Cystinyl bis(1,8-diazaspiro[4.5]decane) as an orally bioavailable L-cystine crystallization inhibitor for cystinuria. ACS Med. Chem. Lett.<\/em> 2024<\/strong>, 15<\/em>(7)<\/span>, 1026\u20131031.<\/span>\u00a0Full Text: PDF\u00a0 \u00a0<\/a>\"\"<\/a>
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  9. Sumi Lee, Ahmed R, Ali, Dhulfiqar Ali Abed, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu<\/strong>* Structural Modification of C2-substituents on 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N’-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction. Eur. J. Med. Chem.<\/em> 2024<\/strong>, 265<\/em>, 116104 (15 pp). Abstract | Full Text: PDF<\/a>
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  10. Jeffrey Yang, Haifa Albanyan, Yiling Wang, Yanhui Yang, Amrik Sahota, Longqin Hu<\/strong>* Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors. Med. Chem. Res.<\/em> 2023<\/strong>, 32<\/em>(7), 1391\u20131399. Full Text: PDF|<\/a>Full-Text View Only Public Link<\/a>
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  11. Dhulfiqar Abed, Ahmed R. Ali, Sumi Lee, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu<\/strong>* Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N\u2032-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur.<\/em> J. Med. Chem.<\/em> 2023<\/strong>, 252<\/em>, 115302 (18 pp). Abstract | Full Text: PDF<\/a>
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  12. Tingying Xie, Husam Zahid, Ahmed R. Ali, Ryan Joyce, Ge Yang, Cassandra Winz, Yicong Le, Renping Zhou, Philip Furmanski, Longqin Hu<\/strong>, Nanjoo Suh* Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer. Toxicol. Appl. Pharmacol. <\/em>2023<\/strong>, 460, 116375 (10 pp). Personal Share Link <\/a>| Abstract | Full Text: PDF<\/a>
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  13. Alexander L. Ruchelman*, Longqin Hu<\/strong> Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie. Med. Chem. Res.<\/em> 2022<\/strong>, 31<\/em>(10), 1621-22. Full Text: PDF|<\/a>Full-Text View Only Public Link\u00a0<\/a><\/li>\n
  14. Jun Wang, Daniel Lam, Jeffrey Yang, Longqin Hu<\/strong>* Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations. Med. Chem. Res.<\/em> 2022<\/strong>, 31<\/em>(10), 1647-62. Full Text: PDF|<\/a>Full-Text View Only Public Link<\/a>
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  15. Jeffrey Yang, Subhadwip Basu, Longqin Hu*<\/strong> Design, synthesis, and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as inhibitors of the programmed cell death-1 (PD-1)\/programmed cell death-ligand 1 (PD-L1) immune checkpoint pathway. Med. Chem. Res.<\/em> 2022<\/strong>, 31<\/em>(10), 1716-39. Full Text: PDF|<\/a>Full-Text View Only Public Link<\/a>
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  16. Sumi Lee, Dhulfiqar Abed, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu<\/strong>* Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N’-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur.<\/em> J. Med. Chem.<\/em> 2022<\/strong>, 237<\/em>, 114380 (17 pp). Abstract | Full Text: PDF<\/a>; Authors Personalized Share Link<\/a>
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  17. Alexander G. Shtukenberg, Longqin Hu<\/strong>, Amrik Sahota, Bart Kahr and Michael D. Ward* Disrupting crystal growth through molecular recognition: designer therapies for kidney stone prevention. Acc. Chem. Res.<\/em> 2022<\/strong>, 55<\/em>, 516-525. Abstract | Full Text: PDF<\/a>
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  18. Dhulfiqar Ali Abed, Sumi Lee, Xia Wen, Ahmed R. Ali, Vaibhav Mangipudy, Lauren M. Aleksunes, and Longqin Hu<\/strong>* Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N’<\/em>-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorg. Med. Chem.<\/em> 2021<\/strong>, 44<\/em>, 116300 (14 pp). Abstract | Full Text: PDF<\/a>
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  19. Moorthy S. S. Palanki, Michael S. Wolfe, Longqin Hu<\/strong> Editorial: Special issue of Medicinal Chemistry Research<\/em> in honor of Professor Gary L. Grunewald. Med. Chem. Res.<\/em> 2021<\/strong>, 30<\/em>(7), 1317-1320. Full Text: PDF<\/a><\/li>\n
  20. Ashwini Sadanand Ranade, Joseph R Bertino, Longqin Hu<\/strong>* Design, Synthesis, and Evaluation of Potential Carbamate Prodrugs of 5\u2019-methylthioadenosine (MTA). Med. Chem. Res.<\/em> 2021<\/strong>, 30<\/em>(7), 1358-1365. Abstract | Full Text: PDF | <\/a>Full-Text View Only Public Link |\u00a0<\/a> Preprint<\/a>
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  21. Sumi Lee, Dhulfiqar Ali Abed, Longqin Hu*<\/strong> Development of a homogeneous time-resolved fluorescence energy transfer (TR-FRET) assay for the inhibition of Keap1-Nrf2 protein-protein interaction. SLAS Discov.<\/em> 2021<\/b>, 26<\/i>(1), 100-112. Abstract | Full Text: PDF<\/a>
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  22. Herve Aloysius, Longqin Hu<\/strong>* Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate specific antigen. Med. Chem. Res.<\/em> 2020<\/strong>, 29<\/em>(7), 1280-1299. Abstract | Full Text: PDF<\/a>; Full-Text View Only Public Link<\/a>
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  23. Herve Aloysius, Longqin Hu<\/strong>* Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate specific antigen. Med. Chem. Res.<\/em> 2020<\/strong>, 29<\/em>(7), 1264-1279. Abstract | Full Text: PDF<\/a>; Full-Text View Only Public Link<\/a>
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  24. Siming L. Wang, Longqin Hu<\/strong>, Binghe Wang Editorial: In honor of Professor Robert P. Hanzlik on the occasion of his retirement. Med. Chem. Res.<\/em> 2020<\/strong>, 29<\/em>(7), 1091-1092. Full Text: PDF<\/a><\/li>\n
  25. Sumi Lee, Longqin Hu*<\/strong> Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction. Med. Chem. Res.<\/em> 2020<\/strong>, 29<\/em>(5), 846-867. Abstract | Full Text: PDF<\/a>; Full-Text View Only Public Link<\/a>
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  26. Dhulfiqar Ali Abed, Sumi Lee, Longqin Hu*<\/strong> Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg. Med. Chem.<\/em> 2020<\/strong>, 28<\/em>(6), 115343 (9 pp). Abstract | Full Text: PDF<\/a>
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  27. Longqin Hu<\/strong> Editorial: Message from the new Editor-in-Chief. Med. Chem. Res. <\/em>2020<\/strong>, 29<\/em>(2), 179. Full Text: PDF<\/a><\/li>\n
  28. Subhadwip Basu, Jeffrey Yang, Bin Xu, Katarzyna Magiera-Mularz, Lukasz Skalniak, Bogdan Musielak, Vladyslav Kholodovych, Tad A. Holak, Longqin Hu<\/strong>* Design, synthesis, evaluation and structural studies of C2-symmetric small molecule inhibitors of the programmed cell death-1\/programmed death-ligand 1 (PD-1\/PD-L1) protein-protein interaction.\u00a0J. Med. Chem.<\/em>\u00a02019<\/strong>, 62<\/em>(15), 7250-63. Abstract | Full Text: PDF<\/a>
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  29. Amrik Sahota*, Jay A. Tischfield, David S. Goldfarb, Michael D. Ward,\u00a0Longqin Hu<\/strong>\u00a0Cystinuria: Genetic aspects, mouse models, and a new approach to therapy.\u00a0Urolithiasis<\/em>\u00a02019<\/strong>,\u00a047<\/em>(1), 57-66.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  30. Jeffrey Yang,\u00a0Longqin Hu<\/strong>* Immunomodulators Targeting the PD-1\/PD-L1 Protein-Protein Interaction: From Antibodies to Small Molecules.\u00a0Med. Res. Rev.<\/em>\u00a02019<\/strong>,\u00a039<\/em>(1), 265-301.\u00a0Abstract | Full Text: PDF<\/a>
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  31. Yanhui Yang, Haifa Albanyan, Sumi Lee, Herve Aloysius, Jian-Jie Liang, Vladyslav Kholodovych, Amrik Sahota,\u00a0Longqin Hu<\/strong>* Design, synthesis, and evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02018<\/strong>,\u00a028<\/em>, 1303-1308.\u00a0SummaryPlus | Full Text + Links | PDF<\/a>
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  32. Jian Shen,* Sadagopan Magesh, Lin Chen,\u00a0Longqin Hu<\/strong>, Yanan He Enantiomeric characterization and structure elucidation of LH601A using vibrational circular dichroism spectroscopy.\u00a0Spectrochim. Acta A Mol Biomol Spectrosc.<\/em>\u00a02018<\/strong>, 192, 312-317.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a>
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  33. Lauren Seabrook,*\u00a0Longqin Hu*<\/strong>\u00a0Insects: An underrepresented resource for the discovery of biologically active natural products.\u00a0Acta Pharm. Sin. B<\/em>\u00a02017<\/strong>,\u00a07<\/em>(4), 409\u2013426.\u00a0Abstract | Full Text + Links | PDF<\/a>
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  34. Laura N. Poloni, Zina Zhu, Nelson G. V\u00e1zquez, Anthony Yu, David Connors,\u00a0Longqin Hu<\/strong>, Amrik Sahota, Michael D. Ward,* Alexander G. Shtukenberg* The role of molecular recognition in L-cystine crystal growth inhibition.\u00a0Cryst. Growth Des.\u00a0<\/em>2017<\/strong>,\u00a017<\/em>(5), 2767\u20132781.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a>
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  35. Longqin Hu<\/strong>,* Yanhui Yang, Herve Aloysius, Haifa Albanyan, Min Yang, Jian-Jie Liang, Anthony Yu, Alexander Shtukenberg, Laura N. Poloni, Vladyslav Kholodovych, Jay A. Tischfield, David Goldfarb, Michael D. Ward, Amrik Sahota L-Cystine Diamides as L-Cystine Crystallization Inhibitors for Cystinuria.\u00a0J. Med. Chem.<\/em>\u00a02016<\/strong>,\u00a059<\/em>(15), 7293-98.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a>
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  36. Jing Zhang, Lu Cheng, Tai-gang Liang, Shurong Ban, Qinshan Li,\u00a0Longqin Hu<\/strong>\u00a0Synthesis and Anti-tumor Activities of Novel Amide Compounds.\u00a0Drugs & Clinic<\/em>\u00a02016<\/strong>,\u00a031<\/em>(9), 1313-1318. [CN].<\/li>\n
  37. Lu Cheng, Jing Zhang, Tai-gang Liang, Shurong Ban, Qinshan Li,\u00a0Longqin Hu<\/strong>\u00a0Synthesis of Novel 3-(4-Fluorophenyl)-4(3H)-pyrimidinone-5-carboxylates.\u00a0Chem. Reagents\u00a0<\/em>2016<\/strong>,\u00a038<\/em>(11), 1125-28. [CN].<\/li>\n
  38. Fern Toh, Wonmo Suh, Haoxun Wang, Peter Zhou,\u00a0Longqin Hu<\/strong>, Geofeng You* Inhibitory effects of chemotherapeutics on human organic anion transporter hOAT4.\u00a0Int. J. Biochem. Mol. Biol.\u00a0<\/em>2016<\/strong>,\u00a07<\/em>(1), 11-18.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  39. Xinghua Wu and\u00a0Longqin Hu<\/strong>* Design and Synthesis of Peptide Conjugates of Phosphoramide Mustard as Prodrugs Activated by Prostate-Specific Antigen.\u00a0Bioorg. Med. Chem<\/em>.\u00a02016<\/strong>,\u00a024<\/em>(12), 2697-2706.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  40. Longqin Hu<\/strong>* Prodrug approaches to drug delivery. In\u00a0Drug Delivery: Principles and Applications<\/em>, 2nd Ed., B. Wang, L. Hu, and T. Siahaan, Eds; John Wiley & Sons: Hoboken, New Jersey,\u00a02016<\/strong>; pp 227-271. [Summary | CrossRef<\/a>]<\/li>\n
  41. Binghe Wang,\u00a0Longqin Hu<\/strong>, and Teruna J.Siahaan, Eds.\u00a0Drug Delivery: Principles and Applications<\/em>, 2nd Ed.; John Wiley & Sons: Hobeken, New Jersey, 2016; 697p. [Table of Contents | CrossRef<\/a>]<\/li>\n
  42. Dhulfiqar Ali Abed, Melanie Goldstein, Haifa Albanyan, Huijuan Jin,\u00a0Longqin Hu<\/strong>* Discovery of Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction as Potential Therapeutic and Preventive Agents (invited review).\u00a0Acta Pharm. Sin. B<\/em>\u00a02015<\/strong>,\u00a05<\/em>(4), 285-299.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  43. Herve Aloysius and\u00a0Longqin Hu<\/strong>* Improving the Specificity of the PSA Substrate Glutaryl-Hyp-Ala-Ser-Chg-Gln as a Promoiety.\u00a0Chem. Biol. Drug Des.<\/em>\u00a02015<\/strong>, 86(4), 837-848.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  44. James A. Sullivan, Jie Lun Tong, Martin Wong, Ambika Kumar, Hajrah Sarkar, Sarah Ali, Ikran Hussein, Iqra Zarman, Emma Louise Meredith, Nuala A. Helsby,\u00a0Longqin Hu<\/strong>\u00a0and Shane R. Wilkinson* Unravelling the Role of the DNA Repair Enzyme SNM1 in Trypanosoma brucei.\u00a0Mol. Microbiol.<\/em>\u00a02015<\/strong>,\u00a096<\/em>(4), 827\u2013838.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  45. Xia Wen, Gabriell Thorne,\u00a0Longqin Hu<\/strong>, Melanie S. Joy, Lauren M. Aleksunes* Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.\u00a0J. Biochem. Mol. Toxicol.\u00a0<\/em>2015<\/strong>,\u00a029<\/em>(6), 261-266.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  46. Herve Aloysius and\u00a0Longqin Hu<\/strong>* Targeted prodrug approaches for hormone refractory prostate cancer.\u00a0Med. Res. Rev.<\/em>\u00a02015<\/strong>,\u00a035<\/em>(3) 554-585.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  47. Lin Chen, Sadagopan Magesh, Hong Wang, Chung S. Yang, Ah-Ng Tony Kong and\u00a0Longqin Hu<\/strong>* Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as potential anti-inflammatory agents.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02014<\/strong>,\u00a024<\/em>(3), 940-943.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  48. Jong hun Lee, Kyeong-Ryoon Lee, Zheng-Yuan Su, Sarandeep Boyanapalli, Dipti Barman, Mou-Tuan Huang, Lin Chen, Magesh Sadagopan,\u00a0Longqin Hu<\/strong>, Ah-Ng (Tony) Kong* In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione.\u00a0Chem. Res. Toxicol.<\/em>\u00a02014<\/strong>,\u00a027<\/em>(1), 34\u201341.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  49. Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama, and\u00a0Longqin Hu<\/strong>* Enzymes and Targeted Activation of Prodrugs. in\u00a0Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents<\/em>, H.C. Yang, W.K. Yeh, and J.R. McCarthy, Eds; Wiley & Sons: New York,\u00a02014<\/strong>, pp 165-235. [Summary | CrossRef<\/a>]<\/li>\n
  50. Yongying Jiang and\u00a0Longqin Hu<\/strong>* Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA).\u00a0Bioorg. Med. Chem.\u00a0<\/em>2013<\/strong>,\u00a021<\/em>(23), 7507-7514.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  51. Grace Buchanan-Kilbey, Joshua Djumpah, Maria V. Papadopoulou,\u00a0Longqin Hu<\/strong>, Shane R. Wilkinson* and Rachel Ashworth* Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish.\u00a0Acta Tropica<\/em>\u00a02013<\/strong>,\u00a0128<\/em>(3), 701\u2013705.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  52. Andrew A. Voak, Karin Seifert, Edina Balczo,\u00a0Longqin Hu<\/strong>, Belinda S. Hall and Shane R. Wilkinson* An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.\u00a0J. Biol. Chem.<\/em>\u00a02013<\/strong>,\u00a0288<\/em>, 28466-28476.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  53. Longqin Hu<\/strong>*, Sadagopan Magesh, Lin Chen, Lili Wang, Timothy A. Lewis, Yu Chen, Carol Khodier, Daigo Inoyama, Lesa J. Beamer, Thomas J. Emge, Jian Shen, John E. Kerrigan, Ah-Ng Tony Kong, Sivaraman Dandapani, Michelle Palmer, Stuart L. Schreiber and Benito Munoz Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02013<\/strong>, 23(10), 3039-3043.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  54. Peng Duan, Shanshan Li, Ni Ai,\u00a0Longqin Hu<\/strong>, William Welsh, Guofeng You* Potent Inhibitors for Organic Anion Transporters 1 and 3 from Clinical Drug Libraries: Discovery and Molecular Characterization.\u00a0Mol. Pharmaceut.<\/em>\u00a02012<\/strong>,\u00a09<\/em>(11), 3340\u20133346.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  55. Yanhui Yang, Andrew Voak, Shane R. Wilkinson, and\u00a0Longqin Hu<\/strong>* Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02012<\/strong>,\u00a022<\/em>(21), 6583\u20136586.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  56. Longqin Hu and Binghe Wang Editorial in honor of the 80th birthday of Professor Lester A. Mitscher.\u00a0Med. Res. Rev.<\/em>\u00a02012<\/strong>,\u00a032<\/em>(4), 685-686. Full Text: PDF<\/a><\/li>\n
  57. Sadagopan Magesh, Yu Chen, and\u00a0Longqin Hu<\/strong>* Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents.\u00a0Med. Res. Rev.<\/em>\u00a02012<\/strong>,\u00a032<\/em>(4), 687-726.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  58. Daigo Inoyama, Yu Chen, Xinyi Huang, Lesa J. Beamer, Ah-Ng Tony Kong, and\u00a0Longqin Hu<\/strong>* Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.\u00a0J. Biomol. Screen.<\/em>\u00a02012<\/strong>,\u00a017<\/em>(4), 435-447 .\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  59. Yu Chen, Daigo Inoyama, Ah-Ng Kong, Lesa J. Beamer, and\u00a0Longqin Hu<\/strong>* Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using Surface Plasmon Resonance.\u00a0Chem. Biol. Drug Des.<\/em>\u00a02011<\/strong>,\u00a078<\/em>(6), 1014-1021.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  60. Yanhui Yang, Herve Aloysius, Daigo Inoyama, Yu Chen, and\u00a0Longqin Hu<\/strong>* Enzyme-mediated hydrolytic activation of prodrugs.\u00a0Acta Pharmaceutica Sinica B<\/em>\u00a02011<\/strong>,\u00a01<\/em>(3), 143-159.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  61. Xinghua Wu, Yu Chen, Herve Aloysius, and\u00a0Longqin Hu<\/strong>* A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: important synthons for the synthesis of chromogenic\/fluorogenic protease substrates.\u00a0Beilstein J. Org. Chem.<\/em>\u00a02011<\/strong>,\u00a07<\/em>, 1030-1035.\u00a0HTML | PDF | Album | Supporting Information<\/a><\/li>\n
  62. Longqin Hu<\/strong>,* Xinghua Wu, Jiye Han, Lin Chen, Simon O. Vass, Patrick Browne, Belinda S. Hall, Christopher Bot, Vithurshaa Gobalakrishnapilla, Peter F. Searle, Richard J. Knox, and Shane R. Wilkinson Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02011<\/strong>,\u00a021<\/em>(13), 3986-3991.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  63. Yang Zhao, Mao-Jung Lee, Connie Cheung, Ji-Hyeung Ju, Yu-Kuo Chen, Ba Liu,\u00a0Longqin Hu<\/strong>, and Chung S. Yang* Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans.\u00a0J. Agric. Food Chem.<\/em>\u00a02010<\/strong>,\u00a058<\/em>(8), 4844\u20134852.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  64. Belinda S. Hall, Xinghua Wu,\u00a0Longqin Hu<\/strong>, and Shane R. Wilkinson* Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.\u00a0Antimicrob. Agents Chemother.\u00a0<\/em>2010<\/strong>,\u00a054<\/em>(3), 1193-1199.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  65. Mansooreh Jaberi-Pour, Simon Vass, Christopher P. Guise, Jane I. Grove, Richard Knox,\u00a0Longqin Hu<\/strong>, Eva I. Hyde and Peter F. Searle* Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.\u00a0Biochem. Pharmacol.<\/em>\u00a02010<\/strong>,\u00a079<\/em>(2), 102-111.\u00a0Abstract | Full Text + Links | PDF<\/a><\/li>\n
  66. Xinghua Wu, Yu Chen, and\u00a0Longqin Hu<\/strong>* An improved practical synthesis of protected <alpha>-amino selenocarboxylates and its application to the synthesis of N-(<alpha>-aminoacyl)sulfonamides.\u00a0Tetrahedron Lett.<\/em>\u00a02009<\/strong>,\u00a050<\/em>(40), 5585-5588.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  67. Auemduan Prawan, Constance Lay Lay Saw, Tin Oo Khor, Young-Sam Keum, Siwang Yu,\u00a0Longqin Hu<\/strong>\u00a0and Ah-Ng Tony Kong* Anti-NF-KB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling.\u00a0Chem. Biol. Interact.\u00a0<\/em>2009<\/strong>,\u00a0179<\/em>(2-3), 202-211.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  68. Yongying Jiang, Robert S. DiPaola, and\u00a0Longqin Hu<\/strong>* Synthesis and stereochemical preference of peptide 4 aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA).\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02009<\/strong>, 19(9), 2587-2590.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  69. Yiyu Ge, Xinhua Wu, Dazhi Zhang, and\u00a0Longqin Hu<\/strong>* 3-Aminoxypropionate-based linker system for cyclization activation in prodrug design.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02009<\/strong>,\u00a019<\/em>(3), 941-944.SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  70. Yu Chen and\u00a0Longqin Hu<\/strong>* Design of anticancer prodrugs for reductive activation.\u00a0Med. Res. Rev.<\/em>\u00a02009<\/strong>,\u00a029<\/em>(1), 29-64.\u00a0Abstract | Full Text: PDF<\/a><\/li>\n
  71. Yongying Jiang and\u00a0Longqin Hu<\/strong>* N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02008<\/strong>,\u00a018<\/em>(14), 4059-4063..\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  72. Auemduan Prawan, Young-Sam Keum, Tin Oo Khor, Siwang Yu, Sujit Nair, Wenge Li,\u00a0Longqin Hu<\/strong>, and Ah-Ng Tony Kong* Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression.\u00a0Pharm. Res.<\/em>\u00a02008<\/strong>,\u00a025<\/em>(4), 836-844.\u00a0[Abstract] [Full Text] [PDF]<\/a><\/li>\n
  73. Young-Sam Keum, Peter Pil-Jae Chang, Ki Han Kwon, Xiaoling Yuan, Wenge Li,\u00a0Longqin Hu<\/strong>, and Ah-Ng Tony Kong* 3-Morpholinopropyl isothiocyanate (3MP-ITC) is a novel synthetic isothiocyanate that strongly induces the antioxidant response element (ARE)-dependent Nrf2-mediated detoxifying\/antioxidant enzymes in vitro and in vivo.\u00a0Carcinogenesis<\/em>\u00a02008<\/strong>,\u00a029<\/em>(3), 594-599.\u00a0[Abstract] [Full Text] [PDF]<\/a><\/li>\n
  74. Yongying Jiang, Zhoupeng Zhang, Robert S. DiPaola, and\u00a0Longqin Hu<\/strong>* Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides.\u00a0Tetrahedron<\/em>\u00a02007<\/strong>,\u00a063<\/em>(43), 10637-10645.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  75. Yiyu Ge and\u00a0Longqin Hu<\/strong>* Microwave-assisted deformylation of N-aryl formamide by KF on basic Al2O3.\u00a0Tetrahedron Lett<\/em>.\u00a02007<\/strong>,\u00a048<\/em>(26), 4585-4588.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  76. Kumar B. Pabbisetty, Xin Yue, Chen Li, Juha-Pekka Himanen, Renping Zhou, Dimitar B. Nikolov, and\u00a0Longqin Hu<\/strong>* Kinetic analysis of binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay.\u00a0Protein Sci.<\/em>\u00a02007<\/strong>,\u00a016<\/em>(3), 355-361.\u00a0Abstract | Full: HTML\/PDF<\/a><\/li>\n
  77. Xinghua Wu and\u00a0Longqin Hu<\/strong>* Efficient amidation from carboxylic acids and azides via selenatriazoline: application to the coupling of amino acids and peptides with azides.\u00a0J. Org. Chem.<\/i>\u00a02007<\/strong>,\u00a072<\/em>(3), 765-774.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  78. Yongying Jiang and\u00a0Longqin Hu<\/strong>* Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage.\u00a0Bioorg. Med. Chem. Lett.<\/i>\u00a0<\/b>2007<\/strong>,\u00a017<\/em>(2), 517-521.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  79. Yongying Jiang, Jiye Han, Chengzhi Yu, Simon O. Vass, Peter F. Searle, Patrick Browne, Richard J. Knox, and\u00a0Longqin Hu<\/strong>* Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzyl phosphoramide mustards for\u00a0E. coli<\/em>\u00a0nitroreductase activation.\u00a0J. Med. Chem.<\/em>\u00a02006<\/strong>,\u00a049<\/em>(14), 4333-4343.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  80. Prathima Surabhi, Xinghua Wu, and\u00a0Longqin Hu<\/strong>* Improved solubility and stability of trialkylammonium selenocarboxylate in organic solvents for efficient amidation with azides.\u00a0Tetrahedron Lett.<\/em>\u00a02006<\/strong>,\u00a047<\/em>(27), 4609-4613.\u00a0SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  81. Raghavendra S. Navath, Kumar B. Pabbisetty, and\u00a0Longqin Hu*<\/strong>\u00a0Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth (III) trichloride.\u00a0Tetrahedron Lett.<\/em>\u00a02006<\/strong>,\u00a047<\/em>(3), 389-393.\u00a0<\/strong>SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  82. Xinghua Wu and\u00a0Longqin Hu<\/strong>* Amide bond formation from selenocarboxylates and aromatic azides.\u00a0Tetrahedron Lett.<\/em>\u00a02005<\/strong>,\u00a046<\/em>(28), 8401-8405.SummaryPlus | Full Text + Links | PDF<\/a><\/li>\n
  83. Longqin Hu<\/strong>* Prodrug approaches to drug delivery. in\u00a0Drug Delivery: Principles and Applications<\/em>, B. Wang, T. Siahaan, and R. Soltero, Eds; John Wiley & Sons: Hoboken, New Jersey,\u00a02005<\/strong>; pp 125-165. [Summary | CrossRef<\/a>]<\/li>\n
  84. Peter F Searle,* Ming-Jen Chen,\u00a0Longqin Hu<\/strong>, Paul R Race, Andrew L Lovering, Jane I Grove, Chris Guise, Mansooreh Jaberipour, Nicholas D James, Vivien Mautner, Lawrence S Young, David J Kerr, Andrew Mountain, Scott A White, and Eva I Hyde Nitroreductase: a prodrug-activating enzyme for gene therapy.\u00a0Clin. Exp. Pharmacol. Physiol.<\/em>\u00a02004<\/strong>,\u00a031<\/em>(11), 811-816.\u00a0Abstract<\/a>\u00a0Full:\u00a0HTML<\/a>\u00a0\/\u00a0PDF<\/a><\/li>\n
  85. Longqin Hu<\/strong>* Prodrugs: Effective Solutions for Solubility, Permeability, and Targeting Challenges, June 28-29, 2004, Philadelphia, PA, USA,\u00a0IDrugs<\/em>\u00a02004<\/strong>,\u00a07<\/em>(8), 736-742. [IDrugs2004<\/a>] [PubMed<\/a>]<\/li>\n
  86. Longqin Hu<\/strong>* The prodrug approach to better targeting.\u00a0Current Drug Discovery<\/em>\u00a02004<\/strong>,\u00a04<\/em>(8), 28-32. [CurrentDrugDiscovery2004<\/a>]<\/li>\n
  87. Longqin Hu<\/strong>,* Chengzhi Yu, Yongying Jiang, Jiye Han, Zhuorong Li, Patrick Browne, Paul R. Race, Richard J. Knox, Peter F. Searle, and Eva I. Hyde Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy.\u00a0J. Med. Chem.<\/em>\u00a02003<\/strong>,\u00a046<\/em>(23), 4818 – 4821.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  88. Zhuorong Li, Jiye Han, Yongying Jiang, Patrick Browne, Richard J. Knox, and\u00a0Longqin Hu<\/strong>* Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture.\u00a0Bioorg. Med. Chem.<\/em>\u00a02003<\/strong>,\u00a011<\/em>(19), 4171-4178.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0PDF<\/a><\/li>\n
  89. Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a05′-(2-Nitrophenylalkanoyl)-2′-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation.\u00a0Bioorg. Med. Chem.<\/em>\u00a02003<\/strong>,\u00a011<\/em>(18), 3889-3899.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0PDF<\/a><\/li>\n
  90. Jun Zhao, Vatee Pattaropong, Yongying Jiang, and\u00a0Longqin Hu*<\/strong>\u00a0Facile synthesis and cleavage of imidazolidines in a novel protection strategy for the preparation of peptides containing a reduced amide bioisostere.\u00a0Tetrahedron Lett.<\/i>\u00a02003<\/strong>,\u00a044<\/em>(2), 229-232.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0PDF<\/a><\/li>\n
  91. Yongying Jiang, Jun Zhao, and\u00a0Longqin Hu*<\/strong>\u00a02,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines.\u00a0Tetrahedron Lett.<\/i>\u00a02002<\/b>,\u00a043<\/i>(26), 4589-4592.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0PDF<\/a><\/li>\n
  92. Chengzhi Yu and\u00a0Longqin Hu*<\/strong>\u00a0Successful Baylis-Hillman Reaction of Acrylamide with Aromatic Aldehydes.\u00a0J. Org. Chem.<\/i>\u00a02002<\/b>,\u00a067<\/i>(1), 219-223.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  93. Chengzhi Yu, Bin Liu, and\u00a0Longqin Hu*<\/strong>\u00a0Efficient Baylis-Hillman reaction using stoichiometric base catalyst and an aqueous medium.\u00a0J. Org. Chem.<\/i>\u00a02001<\/b>,\u00a066<\/i>(16), 5413-5418.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  94. Chengzhi Yu and\u00a0Longqin Hu*<\/strong>\u00a0A facile synthesis of cyclic enecarbamates using Dess-Martin periodinane.\u00a0Tetrahedron Lett.<\/i>\u00a02001<\/b>,\u00a042<\/i>(31), 5167-5170.\u00a0SummaryPlus | Full Text + Links | Journal Format-PDF<\/a><\/li>\n
  95. Chengzhi Yu, Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a0Samarium(0) and 1,1′-dioctyl-4,4′-bipyridinium dibromide: a novel electron-transfer system for the chemoselective reduction of aromatic nitro groups.\u00a0J. Org. Chem.<\/i>\u00a02001<\/b>,\u00a066<\/i>(3), 919-924.\u00a0Abstract | Full: HTML \/ PDF | Supporting Info<\/a><\/li>\n
  96. Chengzhi Yu, Yongying Jiang, Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a0A facile synthesis of 2-oxazolidinones via Hofmann rearrangement medicated by bis(trifluoroacetoxy)iodobenzene.\u00a0Tetrahedron Lett<\/i>.\u00a02001<\/b>,\u00a042<\/i>(8), 1449-1452.\u00a0SummaryPlus | Full Text + Links | Journal Format-PDF<\/a><\/li>\n
  97. Chengzhi Yu, Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a0A simple one-pot procedure for the conversion of alcohols to azides using phosphate activation.\u00a0Org. Lett<\/i>.\u00a02000<\/b>,\u00a02<\/i>(13), 1959-1961.\u00a0Abstract | Full Text – HTML | Full Article – PDF<\/a><\/li>\n
  98. Chengzhi Yu, Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a0A convenient biphasic process for the monosilylation of symmetrical 1,n-primary diols.\u00a0Tetrahedron Lett<\/i>.\u00a02000<\/b>,\u00a041<\/i>(22), 4281-4285.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0Journal Format-PDF<\/a><\/li>\n
  99. Longqin Hu*<\/strong>, Bin Liu and Douglas R. Hacking 5′-[2-(2-Nitrophenyl)-2-methylpropionyl]-2′-deoxy-5-fluorouridine as a potential bioreductive activated prodrug of FUDR: synthesis, stability, and reductive activation.\u00a0Bioorg. Med. Chem. Lett.<\/i>\u00a02000<\/b>,\u00a010<\/i>(8), 797-800.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0Journal Format-PDF<\/a><\/li>\n
  100. Chengzhi Yu, Bin Liu and\u00a0Longqin Hu*<\/strong>\u00a0A modified procedure for the deprotection of methoxymethyl ether.\u00a0Tetrahedron Lett<\/i>.\u00a02000<\/b>,\u00a041<\/i>(6), 819-822.\u00a0SummaryPlus | Full Text + Links<\/a>\u00a0|\u00a0Journal Format-PDF<\/a><\/li>\n
  101. Longqin Hu<\/b>\u00a0and Roberta F. Colman* Resonance Energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at Cys17 and Cys111.\u00a0Biochemistry<\/i>\u00a01997<\/b>,\u00a036<\/i>\u00a0(7),1635-1645.\u00a0Abstract | Full: HTML \/ PDF<\/a><\/li>\n
  102. Longqin Hu<\/b>, Barbara L. Borleske and Roberta F. Colman* Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane.\u00a0Protein Science<\/i>\u00a01997<\/b>,\u00a06<\/i>\u00a0(1), 43-52.\u00a0[Abstract]<\/a>\u00a0[Full Text – HTML]<\/a><\/li>\n
  103. Longqin Hu<\/b>\u00a0and Roberta F. Colman* Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3.\u00a0J. Biol. Chem.<\/i>\u00a01995<\/b>,\u00a0270<\/i>\u00a0(37), 21875-21883.\u00a0[Abstract]<\/a>\u00a0[Full Text]<\/a>\u00a0[PDF]<\/a><\/li>\n
  104. Longqin Hu<\/b>, Preeti Balse and Michael B. Doughty* Neuropeptide Y N-terminal deletion fragments: Correlation between solution structure and receptor binding activity at Y1 receptors in rat brain cortex.\u00a0J. Med. Chem.<\/i>\u00a01994<\/b>,\u00a037<\/i>\u00a0(21), 3622-3629.\u00a0Abstract | Full Text – PDF<\/a><\/li>\n
  105. Longqin Hu<\/b>\u00a0and Michael B. Doughty* Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label.\u00a0J. Protein Chem.<\/i>\u00a01994<\/b>,\u00a013<\/i>\u00a0(1), 135-140.\u00a0Abstract | Full Text – PDF<\/a><\/li>\n
  106. Michael B. Doughty* and\u00a0Longqin Hu<\/b>\u00a0The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment.\u00a0Biopolymers<\/i>\u00a01993<\/b>,\u00a033<\/i>\u00a0(8), 1195-1206.\u00a0Abstract | Full Text – PDF<\/a><\/li>\n
  107. Michael B. Doughty,* Ke Li,\u00a0Longqin Hu<\/b>, Shao Song Chu and Richard Tessel Benextramine neuropeptide Y (NPY) binding site interactions: characterization of NPY binding site heterogeneity in rat brain.\u00a0Neuropeptides<\/i>\u00a01992<\/b>,\u00a023<\/i>\u00a0(3), 169-180.\u00a0[Abstract]<\/a><\/li>\n
  108. Longqin Hu<\/b>\u00a0and Deyu Xu* HPLC separation and characterization of chlorin derivatives with intact ring V from acid degradation products of silkworm excrement crude chlorophyll mixture.\u00a0Biomed. Chromatogr.<\/i>\u00a0(London)\u00a01989<\/b>,\u00a03<\/i>(2), 72-74.\u00a0Abstract | Full Text – PDF<\/a><\/li>\n
  109. Longqin Hu<\/strong>\u00a0and Deyu Xu* Studies on photochemodiagnostic and photochemotherapeutic agents for human malignancies III: separation and identification of pheophorbides from the acid degradation products of silkworm excrement crude chlorophyll.\u00a0Zhongguo Yiyao Gongye Zazhi<\/em>\u00a01988<\/strong>,\u00a019<\/em>(4), 157-161 (Ch).<\/li>\n
  110. Jun Liu,\u00a0Longqin Hu<\/strong>, and Deyu Xu* The sensitizing effect of porphyrin derivatives on the photo oxidation of NADPH in deuterium oxide.\u00a0Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo)<\/em>\u00a01988<\/strong>,\u00a09<\/em>(5), 435-437.<\/li>\n
  111. Lilin Liu*, Jiqiu Yang,\u00a0Longqin Hu<\/strong>, Jianguo Lu, Jianhuang Zhao and Yijie Wu Synthesis and antifungal activity of some imidazolyl oxime ether derivatives.\u00a0J. Med. Coll. PLA<\/em>\u00a01988<\/strong>,\u00a03<\/em>(2), 95-99.<\/li>\n
  112. Lilin Liu*, Jiqiu Yang,\u00a0Longqin Hu<\/strong>, Jianguo Lu, Jianhuang Zhao and Yijie Wu Synthesis and antifungal activity of imidazolyl oxime ether derivatives.\u00a0Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo)\u00a0<\/em>1988<\/strong>,\u00a09<\/em>(2), 100-105 (Ch).<\/li>\n
  113. Longqin Hu<\/strong>\u00a0and Deyu Xu* On the chemistry of pheophorbide a: A novel photosensitizer.\u00a0J. Med. Coll. PLA<\/em>\u00a01987<\/strong>,\u00a02<\/em>(2), 162-166.<\/li>\n
  114. Longqin Hu<\/strong>\u00a0and Deyu Xu* Pheophorbide a as a novel photosensitizer for the Photodynamic Therapy of Cancer.\u00a0Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo)<\/em>\u00a01987<\/strong>,\u00a08<\/em>(1), 1-6 (Ch).<\/li>\n
  115. Longqin Hu<\/strong>\u00a0and Deyu Xu* On the medical applications of chlorophills and derivatives: a review.\u00a0World Pharmacy – Synthetics, Biochemicals and Pharmaceutics (Guowei Yiyao \u2013 Hechengyao, Shenghuayao, Zhiji)<\/em>\u00a01987<\/strong>,\u00a08<\/em>(3), 146-153 (Ch).<\/li>\n
  116. Longqin Hu<\/strong>\u00a0and Deyu Xu* Studies on pheophorbide a as a novel antitumor photosensitizer.\u00a0Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo)\u00a0<\/em>1986<\/strong>,\u00a07<\/em>, 405-409 (Ch).<\/li>\n<\/ol>\n

    Published Patents<\/strong><\/p>\n

      \n
    1. Longqin Hu<\/strong> and Herve Aloysius Peptide linker and combination for prodrugs activated by prostate-specific antigen. US 11,628,221 B2 (2023).<\/li>\n
    2. Longqin Hu<\/strong>\u00a0 Cystine Diamide Analogs for the Prevention of Cystine Stone Formation in Cystinuria. US 11,420,949 B2 (2022).<\/li>\n
    3. Longqin Hu<\/strong> and Herve Aloysius Peptide-linked ester prodrugs activated by prostate-specific antigen. US 11,129,901 B2 (2021).<\/li>\n
    4. Longqin Hu<\/strong> and Amrik Sahota Cystine Diamide Analogs for the Prevention of Cystine Stone Formation in Cystinuria. US 10,836,737 B2 (2020).<\/li>\n
    5. Longqin Hu<\/strong> and Haifa Albanyan Cystine Diamide Analogs for Cystinuria. WO2021119475 (US 62\/947,799), US Patent App. 17\/757,244<\/li>\n
    6. Longqin Hu,<\/strong> Dhulfiqar Ali Abed, and Sumi Lee A Homogenous Time-Resolved Fluorescence Energy Transfer (TR-FRET) Assay for the Inhibition of KEAP1-NRF2 Protein-Protein Interaction. U.S. Provisional Application Serial No. 63\/031,301.<\/li>\n
    7. Longqin Hu<\/strong> and Dhulfiqar Ali Abed Small Molecule Direct inhibitors of Keap1-Nrf2 interaction. PCT\/US20\/13831.<\/li>\n
    8. Longqin Hu<\/strong>, Sadagopan Magesh, Lin Chen, Timothy Lewis, Ben Munos, and Lili Wang Direct inhibitors of Keap1-Nrf2 interaction as antioxidant inflammation modulators. US 10106502 B2 (2018).<\/li>\n
    9. Longqin Hu<\/strong> and Herve Aloysius New peptide-linked ester prodrugs activated by prostate-specific antigen. PCT Int. Appl. <\/em>2018, WO2018144880A1; US2019\/0358337A1.<\/li>\n
    10. Longqin Hu<\/strong> and Amrik Sahota Cystine Diamide Analogs for the Prevention of Cystine Stone Formation in Cystinuria. US9428453 B2 (2016).<\/li>\n
    11. Longqin Hu <\/strong>and Daigo Inoyama HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction<\/em>. US 9075070 B2 (2015).<\/li>\n
    12. Longqin Hu<\/strong>\u00a0and Amrik Sahota Cystine Diamide Analogs for the Prevention of Cystine Stone Formation in Cystinuria. U.S. Patent Application\u00a02014<\/strong>, US20140187546, pp 31.<\/li>\n
    13. Longqin Hu<\/strong>, Sadagopan Magesh, Lin Chen, Timothy Lewis, Ben Munos, and Lili Wang Direct inhibitors of Keap1-Nrf2 interaction as antioxidant inflammation modulators. PCT Int. Appl.\u00a02013<\/strong>, WO 2013067036A1, pp 133.<\/li>\n
    14. Longqin Hu<\/strong>, Ah-Ng Tony Kong, Lin Chen, Sadagopan Magesh, and Constance Lay Lay Saw\u00a0Composition, synthetic process, and use of new antioxidant inflammation modulators<\/em>. PCT Int. Appl.\u00a02012<\/strong>, WO 2012145420A1, pp 111.<\/li>\n
    15. Longqin Hu<\/strong>\u00a0and Daigo Inoyama\u00a0HTS fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction<\/em>. U.S. Pat. Appl. Publ.\u00a02012<\/strong>, US 20120202298A1, pp 20.<\/li>\n
    16. Longqin Hu<\/strong>, Shane R. Wilkinson, Xinghua Wu, and Belinda S. Hall\u00a0Compounds, compositions and methods for treating protozoan infections<\/em>. PCT Int. Appl.\u00a02011<\/strong>, WO 2011066416A1, pp 40.<\/li>\n
    17. Longqin Hu<\/strong>\u00a0and Xinghua Wu\u00a0Preparation of peptide-phosphoramide chemotherapeutic conjugates<\/em>. PCT Int. Appl.\u00a02008<\/strong>, WO 2008067495 A2, pp 57.<\/li>\n
    18. Longqin Hu<\/strong>\u00a0Nitroaryl phosphoramide compositions and methods for targeting and inhibiting undesirable cell growth or proliferation<\/em>. U.S. Pat. Appl. Publ.\u00a02004<\/strong>, US 20040214798 A1, pp 20.<\/li>\n<\/ol>\n

      MyBibliography<\/a><\/p>\n

      Search PubMed for a listing of our publications in Biomedical Journals.<\/a><\/p>\n

      Google Scholar Citations<\/a><\/p>\n

      Search SCOPUS for a listing of our publications from Rutgers.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

      Ahmed Reda Ali, Longqin Hu* N-Mesyl-enabled Cu\u2082O catalysis: Synthesis of (E)-3-alkylideneisoindolin-1-ones and 3,4-unsubstituted isoquinolones via sequential alkynylation\/annulation. J. Org. Chem. 2026, 91(15), 5402-5411. Full Text: PDF Sumi Lee, Ahmed R, … Read More<\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-170","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - Longqin Hu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/longqin-hu\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Longqin Hu\" \/>\n<meta property=\"og:description\" content=\"Ahmed Reda Ali, Longqin Hu* N-Mesyl-enabled Cu\u2082O catalysis: Synthesis of (E)-3-alkylideneisoindolin-1-ones and 3,4-unsubstituted isoquinolones via sequential alkynylation\/annulation. 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