{"id":559,"date":"2024-01-11T23:09:57","date_gmt":"2024-01-11T23:09:57","guid":{"rendered":"https:\/\/sites.rutgers.edu\/longqin-hu\/?page_id=559"},"modified":"2026-01-20T20:06:23","modified_gmt":"2026-01-20T20:06:23","slug":"drugdesign","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/","title":{"rendered":"Principles of Drug Design"},"content":{"rendered":"<div align=\"center\">\n<hr \/>\n<h4 style=\"text-align: left\"><strong>16:663:502 for graduate students \/ 30:715:452 for pharmacy students<\/strong><\/h4>\n<hr \/>\n<h4 style=\"text-align: left\"><strong>Syllabus and Lecture Schedule (<\/strong><span style=\"color: #ff0000\"><strong>new class time in Spring 2026;\u00a0<\/strong><\/span><strong><span style=\"color: #ff0000\">Tuesdays and Thursdays: 4:10 \u2013 5:30 PM, PH 288<\/span>)<\/strong><\/h4>\n<ul>\n<li style=\"text-align: left\">\n<h5><a href=\"http:\/\/sites.rutgers.edu\/longqin-hu\/wp-content\/uploads\/sites\/298\/2026\/01\/DrugDesign_Standardized-Syllabus_Spring2026.pdf\">DrugDesign_Standardized Syllabus_Spring2026<\/a><\/h5>\n<\/li>\n<li style=\"text-align: left\">\n<h5><a href=\"http:\/\/sites.rutgers.edu\/longqin-hu\/wp-content\/uploads\/sites\/298\/2026\/01\/s26courseschedule_502.pdf\">s26courseschedule_502<\/a><\/h5>\n<\/li>\n<\/ul>\n<\/div>\n<hr \/>\n<h4><b>Faculty<\/b><\/h4>\n<ul>\n<li>\n<h5><strong><a href=\"https:\/\/sites.rutgers.edu\/longqin-hu\/\">Dr. Longqin Hu<\/a>\u00a0(Course coordinator)<\/strong><\/h5>\n<h5><strong>\u201cDrug Discovery, Lead Optimization Approaches, Enzymes, R<\/strong><strong>eceptors, Prodrug Design, and Combinatorial Chemistry\u201d<\/strong><\/h5>\n<\/li>\n<li>\n<h5><strong><a href=\"https:\/\/www.linkedin.com\/in\/robert-palmere-28777225b\/\">Dr. Robert Palmere<\/a>\u00a0(Rutgers Office of Advanced Research Computing)<\/strong><\/h5>\n<h5><strong>\u201cComputer Aided Drug Design (CADD)\u201d<\/strong><\/h5>\n<\/li>\n<li>\n<h5><strong><a href=\"https:\/\/www.linkedin.com\/in\/youyi-peng-a032876\/\">Dr. Youyi Peng<\/a> (<span aria-hidden=\"true\">AI Discovery<\/span>, <span class=\"t-14 t-normal\"><span aria-hidden=\"true\">Tonix Pharmaceuticals)<\/span><\/span><\/strong><\/h5>\n<h5><strong>\u201cComputer Aided Drug Design (CADD)\u201d<\/strong><\/h5>\n<\/li>\n<\/ul>\n<h4><b>Invited Seminar Speakers<\/b><strong style=\"font-size: 1rem\">\u00a0<\/strong><\/h4>\n<table style=\"margin-left: 40px;height: 125px\" border=\"1\" width=\"1000\">\n<tbody>\n<tr style=\"border: 1px solid black\">\n<td width=\"20\"><strong>Date<\/strong><\/td>\n<td width=\"120\"><strong>Seminar speakers<\/strong><\/td>\n<td width=\"90\"><strong>Company<\/strong><\/td>\n<td width=\"200\"><strong>Seminar title<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Tuesday, January 27, 2026<\/strong><\/td>\n<td><strong>Dr. Nick Meanwell<\/strong><\/td>\n<td><strong>Formerly, BMS<\/strong><\/td>\n<td><strong>Applications of Bioisosteres in Drug Design<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Tuesday, February 24, 2026<\/strong><\/td>\n<td><strong>Dr. Nick Meanwell<\/strong><\/td>\n<td><strong>Formerly, BMS<\/strong><\/td>\n<td><strong>Applications of Fluorines in Drug Design<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Thursday, February 26, 2026<\/strong><\/td>\n<td><strong>Dr. Lou Lombardo and Dr. Zhicai Shi<\/strong><\/td>\n<td><strong>JNJ<\/strong><\/td>\n<td><strong>Innovative Chemistry Capabilities in Current Drug Discovery Paradigm<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Tuesday, March 3, 2026<\/strong><\/td>\n<td><strong>Dr. Dimitris Agrafiotis<\/strong><\/td>\n<td><strong>Arsenal Capital<\/strong><\/td>\n<td><strong>Application of AI in Drug Discovery<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Thursday, March 5, 2026<\/strong><\/td>\n<td><strong>Dr. Alaric Dyckman<\/strong><\/td>\n<td><strong>BMS<\/strong><\/td>\n<td><strong>Discovery of afimetoran, a small molecule dual antagonist of toll-like receptor 7 and 8 (TLR7\/8) for the treatment of lupus<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Thursday, March 12, 2026<\/strong><\/td>\n<td><strong>Dr. Scott Watterson<\/strong><\/td>\n<td><strong>BMS<\/strong><\/td>\n<td><strong>Multiple Shots on Goal: Dual Approaches to the Design of Inhibitors of Bruton\u2019s Tyrosine Kinase (BTK) that Advanced into Clinical Studies<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Thursday, April 23, 2026<\/strong><\/td>\n<td><strong>Dr. Jennifer Hickey<\/strong><\/td>\n<td><strong>Merck<\/strong><\/td>\n<td><strong>Cyclic peptides for trapping IL-1\u03b2<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Tuesday, April 28, 2026<\/strong><\/td>\n<td><strong>Dr. Ray Bakhtiar<\/strong><\/td>\n<td><strong>Formerly, Novartis, Merck, Teva, Organon &amp; Co.<\/strong><\/td>\n<td><strong>Monoclonal, antibody drug conjugates &amp; peptide therapeutics<\/strong><\/td>\n<\/tr>\n<tr style=\"border: 1px solid black\">\n<td><strong>Thursday, April 30, 2026<\/strong><\/td>\n<td><strong>Dr. Zhoupeng Zhang<\/strong><\/td>\n<td><strong>BMS<\/strong><\/td>\n<td><strong>Metabolic ID and Profiling in Drug Design<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h4><b>Times and Location<\/b><\/h4>\n<ul>\n<li><strong>Tuesdays and Thursdays:\u00a0 4:10 \u2013 5:30 PM, PH 288 (<span style=\"color: #ff0000\">This is the new class time in Spring 2026<\/span>)<\/strong><\/li>\n<\/ul>\n<h4><b>Examinations<\/b><\/h4>\n<ul>\n<li><strong>A term paper or minireview, computational project(s) and one exam<\/strong><\/li>\n<\/ul>\n<hr \/>\n<h4><b>Grading<\/b><\/h4>\n<table style=\"height: 125px;margin-left: 40px\" border=\"1\" width=\"1000\">\n<tbody style=\"padding-left: 40px\">\n<tr style=\"padding-left: 40px\">\n<td><strong>Term paper on a drug target with 5 drug design principles or a minireview article for potential publication in <em>Med. Chem. Res.<\/em><\/strong><\/td>\n<td><strong>20%<\/strong><\/td>\n<\/tr>\n<tr style=\"padding-left: 40px\">\n<td><strong>Exam on approaches to drug discovery (analog design), enzymes, receptors, prodrugs, and combinatorial chemistry<\/strong><\/td>\n<td><strong>40%<\/strong><\/td>\n<\/tr>\n<tr style=\"padding-left: 40px\">\n<td><strong>Computational project(s)<\/strong><\/td>\n<td><strong>35%<\/strong><\/td>\n<\/tr>\n<tr style=\"padding-left: 40px\">\n<td><strong>Class\/seminar attendance and participation<\/strong><\/td>\n<td><strong>5%<\/strong><\/td>\n<\/tr>\n<tr style=\"padding-left: 40px\">\n<td><strong>Total<\/strong><\/td>\n<td><strong>100%<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #0000ff\"><strong>Minireview articles published by students taking the Drug Design course previously<\/strong><\/span><\/h4>\n<ol>\n<li>Ryan L. Bassett\u2020, Giovanni Gallo\u2020, Kim-Phuong N. Le*, Lucio R. Volino Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus. <em>Med. Chem. Res.<\/em>\u00a0<strong>2024<\/strong>,\u00a0<em>33<\/em>(8), 1354-67. <a href=\"https:\/\/doi.org\/10.1007\/s00044-024-03274-4\">Full Text: PDF (Open access)<\/a><\/li>\n<li>Twinkle I. Patel\u2021, Jay N. Joshi\u00a7, Alexander J. Valvezan, Matthew J. Moschitto* A review of trilaciclib, a first-in-class cyclin-dependent kinase 4\/6 inhibitor, for the management of metastatic small-cell lung cancer. <em>Med. Chem. Res.<\/em>\u00a0<strong>2024<\/strong>,\u00a0<em>33<\/em>(10), 1757-68. <a href=\"https:\/\/doi.org\/10.1007\/s00044-024-03288-y\">Full Text: PDF (Open access)<\/a><\/li>\n<li>Ryan P. Joyce\u2021, Vivian W. Hu\u00a7, Jun Wang* The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations. <em>Med. Chem. Res.<\/em>\u00a0<strong>2022<\/strong>,\u00a0<em>31<\/em>(10), 1637-46.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s00044-022-02951-6\">Full Text: PDF|<\/a><a href=\"https:\/\/rdcu.be\/eNvNu\">Full-Text View Only Public Link<\/a><\/li>\n<li>Jun Wang\u2021, Daniel Lam\u00a7, Jeffrey Yang\u2021, Longqin Hu* Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations. <em>Med. Chem. Res.<\/em>\u00a0<strong>2022<\/strong>,\u00a0<em>31<\/em>(10), 1647-62.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s00044-022-02952-5\">Full Text: PDF|<\/a><a href=\"https:\/\/rdcu.be\/cUObW\">Full-Text View Only Public Link<\/a><\/li>\n<\/ol>\n<p style=\"padding-left: 40px\">(\u2020 PharmD Student; \u2021 Graduate Student; \u00a7 MD student, * corresponding author)<\/p>\n<h4><b>Useful Links<\/b><\/h4>\n<p style=\"padding-left: 40px\"><a href=\"https:\/\/sites.rutgers.edu\/longqin-hu\/resources\/\">Literature Search Links<\/a><\/p>\n<p style=\"padding-left: 40px\"><a href=\"https:\/\/www.lgmd-info.org\/wp-content\/uploads\/2025\/03\/Glossary-of-Drug-Development-Terms_.pdf\">Drug discovery &amp; development Glossary<\/a><\/p>\n<p style=\"padding-left: 40px\"><a href=\"http:\/\/publications.iupac.org\/pac\/1998\/pdf\/7005x1129.pdf\">Glossary of terms used in medicinal chemistry- IUPAC<\/a>\u00a0-Pure Appl. Chem., 70, 1129-1143 (1998)<\/p>\n<p style=\"padding-left: 40px\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/cc000071u\">Glossary of terms used in combinatorial chemistry<\/a> \u2013 J.Comb.Chem. 2000, 2, 562-578<\/p>\n<p style=\"padding-left: 40px\">\n","protected":false},"excerpt":{"rendered":"<p>16:663:502 for graduate students \/ 30:715:452 for pharmacy students Syllabus and Lecture Schedule (new class time in Spring 2026;\u00a0Tuesdays and Thursdays: 4:10 \u2013 5:30 PM, PH 288) DrugDesign_Standardized Syllabus_Spring2026 s26courseschedule_502 &hellip; <a href=\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":573,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-559","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Principles of Drug Design - Longqin Hu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Principles of Drug Design - Longqin Hu\" \/>\n<meta property=\"og:description\" content=\"16:663:502 for graduate students \/ 30:715:452 for pharmacy students Syllabus and Lecture Schedule (new class time in Spring 2026;\u00a0Tuesdays and Thursdays: 4:10 \u2013 5:30 PM, PH 288) DrugDesign_Standardized Syllabus_Spring2026 s26courseschedule_502 &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\" \/>\n<meta property=\"og:site_name\" content=\"Longqin Hu\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-20T20:06:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\",\"url\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\",\"name\":\"Principles of Drug Design - Longqin Hu\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/#website\"},\"datePublished\":\"2024-01-11T23:09:57+00:00\",\"dateModified\":\"2026-01-20T20:06:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Principles of Drug Design\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/\",\"name\":\"Longqin Hu\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/longqin-hu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Principles of Drug Design - Longqin Hu","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/","og_locale":"en_US","og_type":"article","og_title":"Principles of Drug Design - Longqin Hu","og_description":"16:663:502 for graduate students \/ 30:715:452 for pharmacy students Syllabus and Lecture Schedule (new class time in Spring 2026;\u00a0Tuesdays and Thursdays: 4:10 \u2013 5:30 PM, PH 288) DrugDesign_Standardized Syllabus_Spring2026 s26courseschedule_502 &hellip; Read More","og_url":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/","og_site_name":"Longqin Hu","article_modified_time":"2026-01-20T20:06:23+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/","url":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/","name":"Principles of Drug Design - Longqin Hu","isPartOf":{"@id":"https:\/\/sites.rutgers.edu\/longqin-hu\/#website"},"datePublished":"2024-01-11T23:09:57+00:00","dateModified":"2026-01-20T20:06:23+00:00","breadcrumb":{"@id":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.rutgers.edu\/longqin-hu\/drugdesign\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.rutgers.edu\/longqin-hu\/"},{"@type":"ListItem","position":2,"name":"Principles of Drug Design"}]},{"@type":"WebSite","@id":"https:\/\/sites.rutgers.edu\/longqin-hu\/#website","url":"https:\/\/sites.rutgers.edu\/longqin-hu\/","name":"Longqin Hu","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.rutgers.edu\/longqin-hu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/pages\/559"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/users\/573"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/comments?post=559"}],"version-history":[{"count":45,"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/pages\/559\/revisions"}],"predecessor-version":[{"id":705,"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/pages\/559\/revisions\/705"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/longqin-hu\/wp-json\/wp\/v2\/media?parent=559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}