Publications
Yang Z, He M, Austin J, Pfleger J, Abdellatif M. Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism. Mol Metab. 2021 Nov;53:101249. doi: 10.1016/j.molmet.2021.101249. Epub 2021 May 11. PubMed PMID: 33989779; PubMed Central PMCID: PMC8188563.
Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M, Sadoshima J. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovasc Res. 2021 Sep 28;117(11):2365-2376. doi: 10.1093/cvr/cvaa298. PubMed PMID: 33070172.
Oka SI, Tang F, Chin A, Ralda G, Xu X, Hu C, Yang Z, Abdellatif M, Sadoshima J. β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes. Antioxidants (Basel). 2021 Jul 20;10(7). doi: 10.3390/antiox10071153. PubMed PMID: 34356388; PubMed Central PMCID: PMC8301070.
Jeon YH, He M, Austin J, Shin H, Pfleger J, Abdellatif M. Adiponectin enhances the bioenergetics of cardiac myocytes via an AMPK- and succinate dehydrogenase-dependent mechanism. Cell Signal. 2021 Feb;78:109866. doi: 10.1016/j.cellsig.2020.109866. Epub 2020 Dec 1. PubMed PMID: 33271223.
Choi S, Pfleger J, Jeon YH, Yang Z, He M, Shin H, Sayed D, Astrof S, Abdellatif M. Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications. Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194436. doi: 10.1016/j.bbagrm.2019.194436. Epub 2019 Nov 1. PubMed PMID: 31682939; PubMed Central PMCID: PMC7187930.
Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI. Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation. Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529. PubMed PMID: 30798619; PubMed Central PMCID: PMC6392084.
Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. PubMed PMID: 30582455; PubMed Central PMCID: PMC6645688.
Shin H, He M, Yang Z, Jeon YH, Pfleger J, Sayed D, Abdellatif M. Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A. Biochim Biophys Acta Gene Regul Mech. 2018 May;1861(5):481-496. doi: 10.1016/j.bbagrm.2018.03.002. Epub 2018 Mar 8. PubMed PMID: 29524612; PubMed Central PMCID: PMC6053077.
Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2016 Jan;126(1):195-206. doi: 10.1172/JCI84015. Epub 2015 Nov 30. PubMed PMID: 26619120; PubMed Central PMCID: PMC4701548.
He M, Yang Z, Abdellatif M, Sayed D. GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy. PLoS One. 2015;10(12):e0145112. doi: 10.1371/journal.pone.0145112. eCollection 2015. PubMed PMID: 26675618; PubMed Central PMCID: PMC4684496.
Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015 Oct 23;117(10):891-904. doi: 10.1161/CIRCRESAHA.115.306624. Epub 2015 Sep 2. PubMed PMID: 26333362; PubMed Central PMCID: PMC4747867.
Pfleger J, He M, Abdellatif M. Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival. Cell Death Dis. 2015 Jul 30;6:e1835. doi: 10.1038/cddis.2015.202. PubMed PMID: 26225774; PubMed Central PMCID: PMC4650745.
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015 Jan 16;116(2):264-78. doi: 10.1161/CIRCRESAHA.116.303356. Epub 2014 Oct 20. PubMed PMID: 25332205.
Sayed D, Yang Z, He M, Pfleger JM, Abdellatif M. Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription. Circ Heart Fail. 2015 Jan;8(1):138-48. doi: 10.1161/CIRCHEARTFAILURE.114.001660. Epub 2014 Nov 14. PubMed PMID: 25398966; PubMed Central PMCID: PMC4401077.
Sayed D, He M, Yang Z, Lin L, Abdellatif M. Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy. J Biol Chem. 2013 Jan 25;288(4):2546-58. doi: 10.1074/jbc.M112.429449. Epub 2012 Dec 10. PubMed PMID: 23229551; PubMed Central PMCID: PMC3554922.
Abdellatif M. Sirtuins and pyridine nucleotides. Circ Res. 2012 Aug 17;111(5):642-56. doi: 10.1161/CIRCRESAHA.111.246546. Review. PubMed PMID: 22904043; PubMed Central PMCID: PMC3496429.
Han M, Yang Z, Sayed D, He M, Gao S, Lin L, Yoon S, Abdellatif M. GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. Cardiovasc Res. 2012 Mar 15;93(4):645-54. doi: 10.1093/cvr/cvs001. Epub 2012 Jan 4. PubMed PMID: 22219180; PubMed Central PMCID: PMC3291090.
Abdellatif M. Differential expression of microRNAs in different disease states. Circ Res. 2012 Feb 17;110(4):638-50. doi: 10.1161/CIRCRESAHA.111.247437. Review. PubMed PMID: 22343558; PubMed Central PMCID: PMC3324925.
Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D. MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex. PLoS One. 2011;6(12):e28324. doi: 10.1371/journal.pone.0028324. Epub 2011 Dec 6. PubMed PMID: 22163007; PubMed Central PMCID: PMC3232211.
Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev. 2011 Jul;91(3):827-87. doi: 10.1152/physrev.00006.2010. Review. PubMed PMID: 21742789.
Han M, Toli J, Abdellatif M. MicroRNAs in the cardiovascular system. Curr Opin Cardiol. 2011 May;26(3):181-9. doi: 10.1097/HCO.0b013e328345983d. Review. PubMed PMID: 21464712.
Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res. 2011 Feb 4;108(3):305-13. doi: 10.1161/CIRCRESAHA.110.228437. Epub 2010 Dec 23. PubMed PMID: 21183740; PubMed Central PMCID: PMC3249645.
Rane S, He M, Sayed D, Yan L, Vatner D, Abdellatif M. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cell Signal. 2010 Jul;22(7):1054-62. doi: 10.1016/j.cellsig.2010.02.008. Epub 2010 Mar 1. PubMed PMID: 20193759; PubMed Central PMCID: PMC2872486.
Sayed D, He M, Hong C, Gao S, Rane S, Yang Z, Abdellatif M. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem. 2010 Jun 25;285(26):20281-90. doi: 10.1074/jbc.M110.109207. Epub 2010 Apr 19. PubMed PMID: 20404348; PubMed Central PMCID: PMC2888441.
Abdellatif M. The role of microRNA-133 in cardiac hypertrophy uncovered. Circ Res. 2010 Jan 8;106(1):16-8. doi: 10.1161/CIRCRESAHA.109.212183. PubMed PMID: 20056941; PubMed Central PMCID: PMC2838710.
Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009 Apr 10;104(7):879-86. doi: 10.1161/CIRCRESAHA.108.193102. Epub 2009 Mar 5. PubMed PMID: 19265035; PubMed Central PMCID: PMC3332328.
Sayed D, Rane S, Abdellatif M. MicroRNAs challenge the status quo of therapeutic targeting. J Cardiovasc Transl Res. 2009 Mar;2(1):100-7. doi: 10.1007/s12265-008-9052-y. Epub 2008 Sep 9. Review. PubMed PMID: 20559973.
Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn DE, Abdellatif M, Feldman DS, Elton TS, Györke S. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ Res. 2009 Feb 27;104(4):514-21. doi: 10.1161/CIRCRESAHA.108.181651. Epub 2009 Jan 8. PubMed PMID: 19131648; PubMed Central PMCID: PMC4394868.
Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H380-8. doi: 10.1152/ajpheart.00225.2008. Epub 2008 Dec 5. PubMed PMID: 19060130; PubMed Central PMCID: PMC2643882.
Sayed D, Rane S, Lypowy J, He M, Chen IY, Vashistha H, Yan L, Malhotra A, Vatner D, Abdellatif M. MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell. 2008 Aug;19(8):3272-82. doi: 10.1091/mbc.e08-02-0159. Epub 2008 May 28. PubMed PMID: 18508928; PubMed Central PMCID: PMC2488276.
Kim SJ, Abdellatif M, Koul S, Crystal GJ. Chronic treatment with insulin-like growth factor I enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H130-5. doi: 10.1152/ajpheart.00298.2008. Epub 2008 May 2. PubMed PMID: 18456736; PubMed Central PMCID: PMC2494754.
Nagy N, Shiroto K, Malik G, Huang CK, Gaestel M, Abdellatif M, Tosaki A, Maulik N, Das DK. Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target. J Mol Cell Cardiol. 2007 May;42(5):981-90. doi: 10.1016/j.yjmcc.2007.02.010. Epub 2007 Feb 24. PubMed PMID: 17397860.
Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007 Mar 30;100(6):914-22. doi: 10.1161/01.RES.0000261924.76669.36. Epub 2007 Mar 1. PubMed PMID: 17332429.
Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res. 2007 Feb 16;100(3):416-24. doi: 10.1161/01.RES.0000257913.42552.23. Epub 2007 Jan 18. PubMed PMID: 17234972.
Chen IY, Lypowy J, Pain J, Sayed D, Grinberg S, Alcendor RR, Sadoshima J, Abdellatif M. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol Chem. 2006 Jul 14;281(28):19369-77. doi: 10.1074/jbc.M601443200. Epub 2006 May 10. PubMed PMID: 16687393.
Lypowy J, Chen IY, Abdellatif M. An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth. J Biol Chem. 2005 Jul 8;280(27):25717-28. doi: 10.1074/jbc.M414266200. Epub 2005 May 9. PubMed PMID: 15886195.
Yatani A, Irie K, Otani T, Abdellatif M, Wei L. RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H650-9. doi: 10.1152/ajpheart.00268.2004. Epub 2004 Oct 7. PubMed PMID: 15471984.
Yue Y, Lypowy J, Hedhli N, Abdellatif M. Ras GTPase-activating protein binds to Akt and is required for its activation. J Biol Chem. 2004 Mar 26;279(13):12883-9. doi: 10.1074/jbc.M312308200. Epub 2004 Jan 5. PubMed PMID: 14707121.
Dibbs ZI, Diwan A, Nemoto S, DeFreitas G, Abdellatif M, Carabello BA, Spinale FG, Feuerstein G, Sivasubramanian N, Mann DL. Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype. Circulation. 2003 Aug 26;108(8):1002-8. doi: 10.1161/01.CIR.0000085203.46621.F4. Epub 2003 Aug 11. PubMed PMID: 12912811.
Depre C, Wang L, Tomlinson JE, Gaussin V, Abdellatif M, Topper JN, Vatner SF. Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart. Cardiovasc Res. 2003 Apr 1;58(1):126-35. doi: 10.1016/s0008-6363(02)00845-3. PubMed PMID: 12667953.
Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MD. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med. 2002 Nov;8(11):1310-7. doi: 10.1038/nm778. Epub 2002 Sep 30. PubMed PMID: 12368904.
Patel R, Nagueh SF, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen HA, Quinones MA, Zoghbi WA, Entman ML, Roberts R, Marian AJ. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation. 2001 Jul 17;104(3):317-24. doi: 10.1161/hc2801.094031. PubMed PMID: 11457751; PubMed Central PMCID: PMC2768618.
MacLellan WR, Xiao G, Abdellatif M, Schneider MD. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol. 2000 Dec;20(23):8903-15. doi: 10.1128/MCB.20.23.8903-8915.2000. PubMed PMID: 11073990; PubMed Central PMCID: PMC86545.
Johnatty SE, Dyck JR, Michael LH, Olson EN, Abdellatif M. Identification of genes regulated during mechanical load-induced cardiac hypertrophy. J Mol Cell Cardiol. 2000 May;32(5):805-15. doi: 10.1006/jmcc.2000.1122. PubMed PMID: 10775485.
Akli S, Zhan S, Abdellatif M, Schneider MD. E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Circ Res. 1999 Aug 20;85(4):319-28. doi: 10.1161/01.res.85.4.319. PubMed PMID: 10455060.
Abdellatif M, Packer SE, Michael LH, Zhang D, Charng MJ, Schneider MD. A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy. Mol Cell Biol. 1998 Nov;18(11):6729-36. doi: 10.1128/MCB.18.11.6729. PubMed PMID: 9774686; PubMed Central PMCID: PMC109256.
Agah R, Kirshenbaum LA, Abdellatif M, Truong LD, Chakraborty S, Michael LH, Schneider MD. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest. 1997 Dec 1;100(11):2722-8. doi: 10.1172/JCI119817. PubMed PMID: 9389735; PubMed Central PMCID: PMC508475.
Abdellatif M, Schneider MD. An effector-like function of Ras GTPase-activating protein predominates in cardiac muscle cells. J Biol Chem. 1997 Jan 3;272(1):525-33. doi: 10.1074/jbc.272.1.525. PubMed PMID: 8995293.select
Kirshenbaum LA, Abdellatif M, Chakraborty S, Schneider MD. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription. Dev Biol. 1996 Nov 1;179(2):402-11. doi: 10.1006/dbio.1996.0270. PubMed PMID: 8903355.
Abdellatif M, MacLellan WR, Schneider MD. p21 Ras as a governor of global gene expression. J Biol Chem. 1994 Jun 3;269(22):15423-6. PubMed PMID: 8195182.
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