Resources
ChIP-Seq and RNA-Seq datasets in GEO, from Abdellatif lab
The mechanisms that regulate H2A.Z and its requirement for transcription in differentiated mammalian cells remains ambiguous. In this study, we identified the interaction between the C-terminus of ANP32e and N-terminus of H2A.Z in a yeast two-hybrid screen. Knockdown of ANP32e resulted in proteasomal degradation and nuclear depletion of H2A.Z or of a chimeric green florescence protein fused to its N-terminus. more…
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE104702
ID: 200104702
Purpose: To identify the differential TFIIB binding patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjected to Transaortic coarctation or adult mice. The hearts were sent to Active Motif for TFIIB- ChIP-Seq. Results: In accordance with previosly published data (Sayed D, et. al. more…
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE56813
ID: 200056813
Purpose: To identify the differential transcriptional patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Results: Our data revealed novel transcriptional patterns during cardiac growth conditions. The results showed that most of the essential genes are regulated by promoter clearance of paused RNA pol II, while de novo recruitment is required for regulation of mostly specialized genes during cardiac growth. more…
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE50637
ID: 200050637
Mice (C57Bl/6J) that are fed increasing levels of dietary fat (0, 10, and 60 Kcal%) show a parallel increasing decline in global promoter-H3K9-butyryl (H3K9Bu), but none in promoter-H3K9-acetyl (H3K9ac), in the heart. Additionally, transverse aortic constriction (TAC) induces a further decline in H3K9Bu, compared to an increase in H3K9ac.
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE165279
ID: 200165279
Balb/cJ mice on a low-fat diet show a decline in promoter H3K9-butyryl (H3K9Bu) in the heart, after subjecting them to transverse aortic constriction (TAC). In contrast, Balb/cByJ, which has a deletion in the ACADS gene, exhibit an increase in promoter H3K9Bu. Conversely, H3K9ac increases in the former and declines in the latter.
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE165271
ID: 200165271
(Submitter supplied) Acetyl-CoA acyltransferace 2 (ACAA2) associates with chromatin at promoter sites in the heart of C57Bl/6J mice. A high-fat vs. low-fat diet reduces it promoter abundance, whereas, transverse aortic constriction (TAC) increases it slight.
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE165284
ID: 200165284
RNA-Seq data show that ACADS knockout curbs gene expression after transverse aortic constriction in mice
Organism: Mus musculus
Type: Expression profiling by high throughput sequencing
Accession: GSE165236
ID: 200165236
RNA-Seq data show that stress combined with a high-fat versus a fat-free diet, evokes greater changes in gene expression
Organism: Mus musculus
Type: Expression profiling by high throughput sequencing
Accession: GSE165085
ID: 200165085
Anti-ACAA2 and anti-OGDH ChIP-high throughput sequencing (Seq) was performed on, normal and 7 day post-transverse aortic constriction, mouse heart tissue (a pool of 3 hearts for each condition)
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Accession: GSE119391
ID: 200119391
Genome-wide mapping of Yap1 in the normal and hypertrophied hearts
(Submitter supplied) anti-Yap1 ChIP-high throughput sequencing (Seq) was performed on normal and 7 day post-transverse aortic constriction mouse heart tissue
Organism: Mus musculus
Type: Genome binding/occupancy profiling by high throughput sequencing
Platform: GPL19057
Accession: GSE115294
ID: 200115294