{"id":367,"date":"2020-07-09T17:50:36","date_gmt":"2020-07-09T17:50:36","guid":{"rendered":"http:\/\/sites.rutgers.edu\/maha-abdellatif\/?page_id=367"},"modified":"2021-12-17T15:41:09","modified_gmt":"2021-12-17T15:41:09","slug":"resources","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/maha-abdellatif\/resources\/","title":{"rendered":"Resources"},"content":{"rendered":"

ChIP-Seq and RNA-Seq datasets in GEO, from Abdellatif lab<\/strong><\/h2>\n
    \n
  1. Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A<\/a><\/li>\n<\/ol>\n

    The mechanisms that regulate H2A.Z and its requirement for transcription in differentiated mammalian cells remains ambiguous. In this study, we identified the interaction between the C-terminus of ANP32e and N-terminus of H2A.Z in a yeast two-hybrid screen. Knockdown of ANP32e resulted in proteasomal degradation and nuclear depletion of H2A.Z or of a chimeric green florescence protein fused to its N-terminus.\u00a0more…<\/a><\/p>\n

    Organism: Mus musculus<\/p>\n

    Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

    Accession:\u00a0 GSE104702<\/p>\n

    ID: 200104702<\/p>\n

     <\/p>\n

      \n
    1. Genome wide TFIIB binding during postnatal and pressure-induced cardiac hypertrophy<\/a><\/li>\n<\/ol>\n

      Purpose: To identify the differential TFIIB binding patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjected to Transaortic coarctation or adult mice. The hearts were sent to Active Motif for TFIIB- ChIP-Seq. Results: In accordance with previosly published data (Sayed D, et. al.\u00a0more…<\/a><\/p>\n

      Organism: Mus musculus<\/p>\n

      Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

      Accession:\u00a0GSE56813<\/p>\n

      ID: 200056813<\/p>\n

        \n
      1. Transcriptional regulation patterns revealed by high-resolution chromatin immunoprecipitation during cardiac hypertrophy<\/a><\/li>\n<\/ol>\n

        Purpose: To identify the differential transcriptional patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Results: Our data revealed novel transcriptional patterns during cardiac growth conditions. The results showed that most of the essential genes are regulated by promoter clearance of paused RNA pol II, while de novo recruitment is required for regulation of mostly specialized genes during cardiac growth.\u00a0more…<\/a><\/p>\n

        Organism: Mus musculus<\/p>\n

        Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

        Accession:\u00a0 GSE50637<\/p>\n

        ID: 200050637<\/p>\n

          \n
        1. The effect of diet on H3K9-butyryl and H3K9-acetyl in the heart before and after transverse aortic constriction in C57Bl\/6J mice<\/a><\/li>\n<\/ol>\n

          Mice (C57Bl\/6J) that are fed increasing levels of dietary fat (0, 10, and 60 Kcal%) show a parallel increasing decline in global promoter-H3K9-butyryl (H3K9Bu), but none in promoter-H3K9-acetyl (H3K9ac), in the heart. Additionally, transverse aortic constriction (TAC) induces a further decline in H3K9Bu, compared to an increase in H3K9ac.<\/p>\n

          Organism: Mus musculus<\/p>\n

          Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

          Accession:\u00a0GSE165279<\/p>\n

          ID: 200165279<\/p>\n

            \n
          1. H3K9-butyryl (H3K9Bu) and H3K9-acetyi (H3K9ac) genome patterns before and after transverse aortic constriction in Balb\/cJ and Balc\/cByJ mice<\/a><\/li>\n<\/ol>\n

            Balb\/cJ mice on a low-fat diet show a decline in promoter H3K9-butyryl (H3K9Bu) in the heart, after subjecting them to transverse aortic constriction (TAC). In contrast, Balb\/cByJ, which has a deletion in the ACADS gene, exhibit an increase in promoter H3K9Bu. Conversely, H3K9ac increases in the former and declines in the latter.<\/p>\n

            Organism: Mus musculus<\/p>\n

            Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

            Accession:\u00a0GSE165271<\/p>\n

            ID: 200165271<\/p>\n

              \n
            1. ACAA2 genome-binding patterns before and after transverse aortic constriction in C57Bl\/6J mice on different diets [ACAA2]<\/a><\/li>\n<\/ol>\n

              (Submitter supplied) Acetyl-CoA acyltransferace 2 (ACAA2) associates with chromatin at promoter sites in the heart of C57Bl\/6J mice. A high-fat vs. low-fat diet reduces it promoter abundance, whereas, transverse aortic constriction (TAC) increases it slight.<\/p>\n

              Organism: Mus musculus<\/p>\n

              Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

              Accession:\u00a0GSE165284<\/p>\n

              ID: 200165284<\/p>\n

                \n
              1. The effect of transverse aortic constriction on gene expression in Balb\/cJ versus Balb\/cByJ(\u2206ACADS) mice hearts<\/a><\/li>\n<\/ol>\n

                RNA-Seq data show that ACADS knockout curbs gene expression after transverse aortic constriction in mice<\/p>\n

                Organism: Mus musculus<\/p>\n

                Type: Expression profiling by high throughput sequencing<\/p>\n

                Accession:\u00a0GSE165236<\/p>\n

                ID: 200165236<\/p>\n

                  \n
                1. Diet- and stress-induced changes of RNA in mouse heart<\/a><\/li>\n<\/ol>\n

                  RNA-Seq data show that stress combined with a high-fat versus a fat-free diet, evokes greater changes in gene expression<\/p>\n

                  Organism: Mus musculus<\/p>\n

                  Type: Expression profiling by high throughput sequencing<\/p>\n

                  Accession:\u00a0GSE165085<\/p>\n

                  ID: 200165085<\/p>\n

                    \n
                  1. ACAA2 and OGDH bind to H2A.Z-occupied transcription start sites<\/a><\/li>\n<\/ol>\n

                    Anti-ACAA2 and anti-OGDH ChIP-high throughput sequencing (Seq) was performed on, normal and 7 day post-transverse aortic constriction, mouse heart tissue (a pool of 3 hearts for each condition)<\/p>\n

                    Organism: Mus musculus<\/p>\n

                    Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

                    Accession:\u00a0GSE119391<\/p>\n

                    ID: 200119391<\/p>\n

                     <\/p>\n

                    Genome-wide mapping of Yap1 in the normal and hypertrophied hearts<\/a><\/p>\n

                    (Submitter supplied) anti-Yap1 ChIP-high throughput sequencing (Seq) was performed on normal and 7 day post-transverse aortic constriction mouse heart tissue<\/p>\n

                    Organism: Mus musculus<\/p>\n

                    Type: Genome binding\/occupancy profiling by high throughput sequencing<\/p>\n

                    Platform:\u00a0GPL19057<\/a><\/p>\n

                    Accession:\u00a0GSE115294<\/p>\n

                    ID: 200115294<\/p>\n

                     <\/p>\n","protected":false},"excerpt":{"rendered":"

                    ChIP-Seq and RNA-Seq datasets in GEO, from Abdellatif lab Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A The mechanisms that regulate H2A.Z and its requirement for … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-367","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResources - Maha Abdellatif<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/maha-abdellatif\/resources\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resources - Maha Abdellatif\" \/>\n<meta property=\"og:description\" content=\"ChIP-Seq and RNA-Seq datasets in GEO, from Abdellatif lab Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A The mechanisms that regulate H2A.Z and its requirement for … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/maha-abdellatif\/resources\/\" \/>\n<meta property=\"og:site_name\" content=\"Maha Abdellatif\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-17T15:41:09+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/maha-abdellatif\/resources\/\",\"url\":\"https:\/\/sites.rutgers.edu\/maha-abdellatif\/resources\/\",\"name\":\"Resources - 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