{"id":599,"date":"2026-01-05T00:38:17","date_gmt":"2026-01-05T00:38:17","guid":{"rendered":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/?p=599"},"modified":"2026-01-05T00:38:17","modified_gmt":"2026-01-05T00:38:17","slug":"age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/","title":{"rendered":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports"},"content":{"rendered":"<p>Our new paper, published in Cell Reports, provides a comprehensive foundation of the gene regulatory mechanisms controlling senescence in CD8+ T cells in humans and provides new avenues for the modulation of this important cell state by the rational targeting of its transcription factor networks. Check it out at:\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124725015670\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124725015670<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our new paper, published in Cell Reports, provides a comprehensive foundation of the gene regulatory mechanisms controlling senescence in CD8+ T cells in humans and provides new avenues for the &hellip; <a href=\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":2661,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-599","post","type-post","status-publish","format-standard","hentry","category-tf-network-dynamics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab\" \/>\n<meta property=\"og:description\" content=\"Our new paper, published in Cell Reports, provides a comprehensive foundation of the gene regulatory mechanisms controlling senescence in CD8+ T cells in humans and provides new avenues for the &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\" \/>\n<meta property=\"og:site_name\" content=\"Mart\u00ednez Zamudio Lab\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-05T00:38:17+00:00\" \/>\n<meta name=\"author\" content=\"Ricardo I. Martinez Zamudio\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ricardo I. Martinez Zamudio\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\",\"url\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\",\"name\":\"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#website\"},\"datePublished\":\"2026-01-05T00:38:17+00:00\",\"dateModified\":\"2026-01-05T00:38:17+00:00\",\"author\":{\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/240b52dcc66b7be630b9240fb444bbf6\"},\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/\",\"name\":\"Mart\u00ednez Zamudio Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/240b52dcc66b7be630b9240fb444bbf6\",\"name\":\"Ricardo I. Martinez Zamudio\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/6a480f9bc255f8ee5e7ce93e60f77ae1?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/6a480f9bc255f8ee5e7ce93e60f77ae1?s=96&d=mm&r=g\",\"caption\":\"Ricardo I. Martinez Zamudio\"},\"url\":\"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/author\/rm1238\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/","og_locale":"en_US","og_type":"article","og_title":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab","og_description":"Our new paper, published in Cell Reports, provides a comprehensive foundation of the gene regulatory mechanisms controlling senescence in CD8+ T cells in humans and provides new avenues for the &hellip; Read More","og_url":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/","og_site_name":"Mart\u00ednez Zamudio Lab","article_published_time":"2026-01-05T00:38:17+00:00","author":"Ricardo I. Martinez Zamudio","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Ricardo I. Martinez Zamudio","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/","url":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/","name":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports - Mart\u00ednez Zamudio Lab","isPartOf":{"@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#website"},"datePublished":"2026-01-05T00:38:17+00:00","dateModified":"2026-01-05T00:38:17+00:00","author":{"@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/240b52dcc66b7be630b9240fb444bbf6"},"breadcrumb":{"@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans-published-in-cell-reports\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/"},{"@type":"ListItem","position":2,"name":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports"}]},{"@type":"WebSite","@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#website","url":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/","name":"Mart\u00ednez Zamudio Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/240b52dcc66b7be630b9240fb444bbf6","name":"Ricardo I. Martinez Zamudio","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/6a480f9bc255f8ee5e7ce93e60f77ae1?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6a480f9bc255f8ee5e7ce93e60f77ae1?s=96&d=mm&r=g","caption":"Ricardo I. Martinez Zamudio"},"url":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/author\/rm1238\/"}]}},"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/posts\/599"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/users\/2661"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/comments?post=599"}],"version-history":[{"count":1,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/posts\/599\/revisions"}],"predecessor-version":[{"id":600,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/posts\/599\/revisions\/600"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/media?parent=599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/categories?post=599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/martinez-zamudio-lab\/wp-json\/wp\/v2\/tags?post=599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}