Skip to main content

Publications

12. Patel, T.I., Joshi, J.N., Valvezan, A. J., Moschitto M.J.,  A Review of Trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer. J. Med Chem. Res. 2024, 33, 1757–1768.  https://doi.org/10.1007/s00044-024-03288-y

11.  Patel, T.I., Chi, Y., Laha, R., Moschitto, M.J., Streamlining SuFEx Inhibitor Development: A Unified Approach Using Orthogonal Sulfinate Protecting Groups. ChemRxiv 2024. https://chemrxiv.org/engage/chemrxiv/article-details/65fc59f39138d23161f3aa50

10.  Patel, T. I Laha, R.; Moschitto, M. J., Synthesis of quinoline silyloxymethylsulfones as intermediates to sulfonyl derivatives. J. Org Chem. 2022, 87, 15679–15683DOI: 10.1021/acs.joc.2c02044

9. Laha, R.; Patel, T. I.; Moschitto, M. J., Desulfinative Alkylation of Heteroarenes via an Electrostatic Electron Donor-Acceptor Complex. Org. Lett. 2022, 24, 7394-7399.  DOI:10.1021/acs.orglett.2c02932

8. Weerawarna, P. M.; Moschitto, M. J.; Silverman, R. B., Theoretical and mechanistic validation of global kinetic parameters of the inactivation of GABA aminotransferase by OV329 and CPP-115. ACS Chem. Biol. 2021, 16, 615-630.

7. Moschitto. M.J., Doubleday, P.F., Catlin. D. S., Kelleher, N. L., Liu, D., Silverman, R. B., “Mechanism of action of (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid, a selective inhibitor of ornithine aminotransferase.” J. Am. Chem. Soc. 2019, 141, 10711-10721.

6. Moschitto. M.J., Silverman R.B. “Synthesis of (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.” Org. Lett. 2018, 20, 4589-4592.
Highlighted: Synfacts 2018; 14(10): 1011.

5. Juncosa, J. I. Takaya, K. Le, H. V. Moschitto, M. J. Weerawarna, P. M.; Mascarenhas, R. Liu, D. Dewey, S. L. Silverman, R. B. “Design and mechanism of (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a Highly potent γ-aminobutyric acid aminotransferase inactivator for the treatment of addiction.” J. Am. Chem. Soc. 2018, 140, 2151–2164.
Highlighted: Service, R. F. “Chemists seek antiaddiction drugs to battle hijacked brain.” Science  2018, 360, 139-140.

4. Moschitto, M.J., Lewis, C.A., “Synthesis of the rubiyunnanin B core aglycone” Eur. J. Org. Chem. 2016, 28, 4773-4777.

4. Lewis, C.A., Moschitto, M.J., Vaccarello, D.N., “Allylic oxide regio-resolution as a tool for the synthesis and transfer of carbasugars.” Synlett, 2015, 26, 2473–2478.

3. Moschitto, M. J., Anthony, D. R., and Lewis, C. A., “Syntheses of arnottin I and arnottin II,” J. Org. Chem., 2015, 80, 3339-3342.

2. Vaccarello, D.N., Moschitto, M.J., Lewis, C.A., “Regiodivergent addition of phenols to allylic oxides.”J. Org. Chem., 2015, 80, 5252-5259.

1. Moschitto, M. J., Vaccarello, D. N., and Lewis, C. A., “Regiodivergent addition of phenols to allylic oxides: control of 1,2- and 1,4-additions for cyclitol synthesis,” Angew. Chem. Int. Ed, 2015, 54, 2142-2145.

 

Patents

  1. Moschitto, M., Silverman, R. B, U.S. Patent 62/814026 (May 5, 2019) Process for the synthesis  of (S)- 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.
  2. Moschitto, M., Silverman R. B., U.S. patent 62/810018 (February 25th, 2019) Analogues of 3-amino-4-(propan-2-ylidene) cyclopentane-1-carboxylic acid.
  3. Moschitto, M., Silverman, R. B, U.S. Patent 62/676373 (May 25, 2018) Process for the synthesis  of (S)- 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.