Robinson, Latrisha: Using A Zebrafish Model for Evaluating Alterations of Microglia Morphology Following Lipopolysaccharides Exposure
Title: Using A Zebrafish Model for Evaluating Alterations of Microglia Morphology Following Lipopolysaccharides Exposure
Name: Latrisha Robinson
Home Institute: New Jersey City University
Programs: RISE program, INSPIRE Postdoctoral Research and Education Program
Other contributors: Michelle Billott, Cassandra Winz, Victoria DiBona
Abstract: Microglia cells are macrophages located in the central nervous system that are known to mediate an immune response that clears cellular death and debris. The main function of microglia cells is important for normal brain development and regeneration. Current research is lacking on the effects of toxicant exposure during fetal development, including from mother’s diet or proximity to farms that spray pesticides.
To this end, we are first reconstructing whole microglia cells from five day post fertilized (5 dpf) zebrafish to assess for alteration in cellular morphology following varying dosage of the known immune activator lipopolysaccharides (LPS). These reconstructions will allow us to establish if microglia from the zebrafish model do have a spectrum of morphology, allowing us to next evaluate the effects on pesticide exposed zebrafish.
Biography: My name is Latrisha Robinson and I recently graduated from New Jersey City University with a bachelor’s degree in Psychology with a double minor in Women’s & Gender Studies and Biology. My end goal is to become a psychiatrist and provide affordable service for the lower income community.