{"id":2224,"date":"2020-05-29T01:29:10","date_gmt":"2020-05-29T01:29:10","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/?page_id=2224"},"modified":"2020-06-01T02:41:22","modified_gmt":"2020-06-01T02:41:22","slug":"daguplo-heineken-queen","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/daguplo-heineken-queen\/","title":{"rendered":"Daguplo, Heineken Queen: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2"},"content":{"rendered":"

\"Heineken<\/a>
\nView video presentation<\/a><\/strong><\/p>\n

Title:<\/strong> Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2<\/p>\n

Name:<\/strong> Heineken Queen Daguplo<\/p>\n

Major:<\/strong> Biochemistry<\/p>\n

School affiliation:<\/strong> Douglass Residential College, School of Environmental and Biological Sciences<\/p>\n

Programs:<\/strong> Project SUPER; George H. Cook Scholars Program<\/p>\n

Other contributors:<\/strong> Swati Rajput, Chadni Patel, and Estela Jacinto<\/p>\n

Abstract:<\/strong> The mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular processes, mainly cell growth and proliferation. Alterations in the regular activity that cells in our body partake in can result in metabolic diseases such as cancer. mTOR is comprised of two complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). It is known that mTORC1 modulates anabolic activities in the cell, whereas mTORC2 plays a role in both anabolic and catabolic processes. Moreover, another protein kinase that affects cell proliferation and translation is the P90 ribosomal S6 kinase (RSK), that is phosphorylated at the homologous HM site, Ser380. Here we are trying to investigate the relationship between mTORC2 and RSK by analyzing phosphorylation of the HM sites in response to nutrient conditions. Previous work from our lab found that RSK phosphorylation is affected by mTORC2 integrity, thus we are trying to further our understanding about the connection between the two proteins. Interestingly, we found that nutrient deprivation could robustly increase RSK-Ser380 phosphorylation. Since mTORC2 is activated by nutrient starvation, our findings suggest that mTORC2 is required for RSK-Ser380 phosphorylation likely via its role in sensing nutrient stress. Thus, additional experiments are needed to elucidate the link between mTORC2 and RSK phosphorylation. Our results provide insights on how cells respond to nutrient stress and how deregulation of these signaling molecules could promote metabolic disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"

View video presentation Title: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2 Name: Heineken Queen Daguplo Major: Biochemistry School affiliation: Douglass Residential College, School of Environmental and Biological … Read More<\/a><\/p>\n","protected":false},"author":970,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2224","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nDaguplo, Heineken Queen: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2 - Senior Exhibits<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/daguplo-heineken-queen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Daguplo, Heineken Queen: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2 - Senior Exhibits\" \/>\n<meta property=\"og:description\" content=\"View video presentation Title: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2 Name: Heineken Queen Daguplo Major: Biochemistry School affiliation: Douglass Residential College, School of Environmental and Biological … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/daguplo-heineken-queen\/\" \/>\n<meta property=\"og:site_name\" content=\"Senior Exhibits\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-01T02:41:22+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/05\/Heineken-Queen_Daguplo-RSK-Poster_thumbnail-300x225.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/daguplo-heineken-queen\/\",\"url\":\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/daguplo-heineken-queen\/\",\"name\":\"Daguplo, Heineken Queen: Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2 - 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