{"id":2874,"date":"2020-08-06T18:54:49","date_gmt":"2020-08-06T18:54:49","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/?page_id=2874"},"modified":"2020-08-07T00:02:03","modified_gmt":"2020-08-07T00:02:03","slug":"bu-sha-antonio","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/bu-sha-antonio\/","title":{"rendered":"Bu Sha, Antonio: Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding"},"content":{"rendered":"<p><a href=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-2825 alignleft\" src=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter_thumbnail-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter_thumbnail-300x225.png 300w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter_thumbnail-1024x768.png 1024w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter_thumbnail-768x576.png 768w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/antoniobu_shaposter_thumbnail.png 1067w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n<strong>Title:<\/strong> Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding<\/p>\n<p><strong>Name:\u00a0<\/strong>Antonio Bu Sha<\/p>\n<p><strong>Major:<\/strong> Mechanical Engineering<\/p>\n<p><strong>School affiliation:<\/strong> School of Engineering<\/p>\n<p><strong>Programs:<\/strong> Aresty Summer Science Program<\/p>\n<p><strong>Other contributors:<\/strong> Wilma Olson<\/p>\n<p><strong>Abstract:<\/strong> While it is well understood that the DNA sequence (ATCG) contains the information for how to construct the proteins and RNA that allow most life to function, the role of DNA folding in gene expression is not well understood. DNA is stored in the nucleus by being wrapped around collections of proteins called histones, to form a nucleosome. Our research group is investigating how the specific way that DNA wraps<br \/>\naround histones impacts the detachment and subsequent processing of the interacting DNA. Our research group used programs to produce computational models of nucleosomes from the Protein Data Bank (PDB) by analyzing the properties of individual interactions between the DNA and histones. By cataloging and analyzing these interactions, trends across multiple structures can be observed. Preliminary data suggest that DNA often binds asymmetrically to the histone core and may unravel more easily from the side with fewer interactions with histones. This research shows that analyzing histone-DNA interactions will help us better understand DNA folding in nucleosomes. Further research is planned to analyze the effects of non-histone proteins on the way that DNA wraps and unwraps around the histone core.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding Name:\u00a0Antonio Bu Sha Major: Mechanical Engineering School affiliation: School of Engineering Programs: Aresty Summer Science Program Other contributors: Wilma &hellip; <a href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/bu-sha-antonio\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":970,"featured_media":0,"parent":441,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2874","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bu Sha, Antonio: Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding - Senior Exhibits<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/bu-sha-antonio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bu Sha, Antonio: Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding - Senior Exhibits\" \/>\n<meta property=\"og:description\" content=\"Title: Big Data Analysis on How Protein-DNA Interactions Impact Nucleosome Folding Name:\u00a0Antonio Bu Sha Major: Mechanical Engineering School affiliation: School of Engineering Programs: Aresty Summer Science Program Other contributors: Wilma &hellip; 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