{"id":3048,"date":"2020-08-09T01:33:44","date_gmt":"2020-08-09T01:33:44","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/?page_id=3048"},"modified":"2020-08-09T01:36:57","modified_gmt":"2020-08-09T01:36:57","slug":"colina-alyssa","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/colina-alyssa\/","title":{"rendered":"Colina, Alyssa: Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration"},"content":{"rendered":"<p><a href=\"https:\/\/rutgers.box.com\/s\/hig725xzdr2ga02i8rg5jyq3fp1esajs\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-2824 alignleft\" src=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/alyssacolinaposter_thumbnail-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/alyssacolinaposter_thumbnail-300x225.png 300w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/alyssacolinaposter_thumbnail-1024x768.png 1024w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/alyssacolinaposter_thumbnail-768x576.png 768w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/alyssacolinaposter_thumbnail.png 1067w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n<strong>Title:<\/strong> Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration<\/p>\n<p><strong>Name:<\/strong> Alyssa Colina<\/p>\n<p><strong>Major:<\/strong> Exercise Science<\/p>\n<p><strong>School affiliation:<\/strong> School of Arts and Sciences<\/p>\n<p><strong>Programs:<\/strong> Aresty Summer Science Program<\/p>\n<p><strong>Other contributors:<\/strong> David Barker<\/p>\n<p><strong>Abstract:<\/strong> While there have been many studies based upon the lateral preoptic area\u2019s (LPO) contribution to locomotion (Shreve &amp; Uretsky, 1990), there have been few that highlighted the specific activity of its neuronal population in drug addiction. Thus, the goal of the present study is to more clearly define the lateral preoptic area\u2019s role in the reward circuitry by examining the phasic activity of lateral preoptic neurons during drug-seeking behavior. Through the use of in vivo electrophysiology, a technique used to record the activity of single neurons, the activity of lateral preoptic area neurons were recorded during specific aspects of drug-seeking behavior such as the pre lever-press period, the drug seeking lever press response, and the delivery of the infusion. Neurons were most responsive during the lever press phase, with different neurons showing either an increase or a decrease in firing rate. During the lever press phase, whether firing rate increased or decreased, the neuronal firing rate also decreased when rats received an infusion of cocaine. This shows us that the lateral preoptic area is important for certain types of drug-seeking behavior such as lever pressing, a drug seeking response. The data also suggests that two different and opposing responses exist. These may represent the activity of the classes of neurons we know to exist in this area: glutamatergic and GABAergic neurons (Barker et al., 2017). These results suggest that the lateral preoptic area may represent a previously unrecognized contributor to drug-seeking behavior and drug addiction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration Name: Alyssa Colina Major: Exercise Science School affiliation: School of Arts and Sciences Programs: Aresty Summer Science Program &hellip; <a href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/colina-alyssa\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":970,"featured_media":0,"parent":441,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3048","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Colina, Alyssa: Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration - Senior Exhibits<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/colina-alyssa\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Colina, Alyssa: Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration - Senior Exhibits\" \/>\n<meta property=\"og:description\" content=\"Title: Investigating the Role of the Lateral Preoptic Area During Cocaine Self-Administration Name: Alyssa Colina Major: Exercise Science School affiliation: School of Arts and Sciences Programs: Aresty Summer Science Program &hellip; 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