{"id":3087,"date":"2020-08-09T03:07:06","date_gmt":"2020-08-09T03:07:06","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/?page_id=3087"},"modified":"2020-08-09T03:10:55","modified_gmt":"2020-08-09T03:10:55","slug":"lenkeit-evan","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/lenkeit-evan\/","title":{"rendered":"Lenkeit, Evan: Designing an Oral Drug for SARS-CoV-2"},"content":{"rendered":"<p><a href=\"https:\/\/rutgers.box.com\/s\/mqwbnjw6ycf4a2wcvle4kcyb26y5ltf2\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-2831 alignleft\" src=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/EvanLenkeitPoster_thumbnail-300x225.png\" alt=\"Evan Lenkeit\" width=\"300\" height=\"225\" srcset=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/EvanLenkeitPoster_thumbnail-300x225.png 300w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/EvanLenkeitPoster_thumbnail-1024x768.png 1024w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/EvanLenkeitPoster_thumbnail-768x576.png 768w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/EvanLenkeitPoster_thumbnail.png 1067w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n<strong>Title:<\/strong> Designing an Oral Drug for SARS-CoV-2<\/p>\n<p><strong>Name:<\/strong> Evan Lenkeit<\/p>\n<p><strong>Major:<\/strong> Chemistry<\/p>\n<p><strong>School affiliation:<\/strong> School of Arts and Sciences<\/p>\n<p><strong>Programs:<\/strong> Aresty Summer Science Program<\/p>\n<p><strong>Other contributors:<\/strong> Stephanie Laporte, Mark Dresel, and Spencer Knapp<\/p>\n<p><strong>Abstract:<\/strong> With the outbreak of the COVID-19 pandemic, there is an immense need for new molecules for treating the virus. Based on available data, the drug Remdesivir (Gilead Sciences) has shown promising activity in treating the virus. By using flexible alignment calculations, several potential candidates for future development as treatments have been identified. The candidates are isosorbide analogues, which preserve Remdesivir\u2019s functional groups\u2019 relative positions in space. The proposed molecules have the added potential of greater water solubility, allowing for development of a pill to be administered orally. An oral treatment could be especially advantageous for patients with limited access to healthcare since Remdesivir must be administered intravenously, which requires additional medical supplies and personnel. Thus, the proposed candidates have greater potential for efficacious treatment in impoverished or rural areas with little access to healthcare.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Designing an Oral Drug for SARS-CoV-2 Name: Evan Lenkeit Major: Chemistry School affiliation: School of Arts and Sciences Programs: Aresty Summer Science Program Other contributors: Stephanie Laporte, Mark Dresel, &hellip; <a href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/lenkeit-evan\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":970,"featured_media":0,"parent":441,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3087","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lenkeit, Evan: Designing an Oral Drug for SARS-CoV-2 - Senior Exhibits<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/aresty-research-virtual-symposium-2020\/lenkeit-evan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lenkeit, Evan: Designing an Oral Drug for SARS-CoV-2 - Senior Exhibits\" \/>\n<meta property=\"og:description\" content=\"Title: Designing an Oral Drug for SARS-CoV-2 Name: Evan Lenkeit Major: Chemistry School affiliation: School of Arts and Sciences Programs: Aresty Summer Science Program Other contributors: Stephanie Laporte, Mark Dresel, &hellip; 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