{"id":3306,"date":"2020-08-14T18:17:35","date_gmt":"2020-08-14T18:17:35","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/?page_id=3306"},"modified":"2020-08-14T18:22:05","modified_gmt":"2020-08-14T18:22:05","slug":"kumar-rohit","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/dls-division-of-life-sciences\/kumar-rohit\/","title":{"rendered":"Kumar, Rohit: The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis"},"content":{"rendered":"<p><a href=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3178 alignleft\" src=\"http:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster_thumbnail-300x232.png\" alt=\"\" width=\"300\" height=\"232\" srcset=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster_thumbnail-300x232.png 300w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster_thumbnail-1024x791.png 1024w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster_thumbnail-768x594.png 768w, https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/wp-content\/uploads\/sites\/442\/2020\/08\/Rohit-Kumar-Poster_thumbnail.png 1035w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><strong><a class=\"btn btn-primary\" href=\"https:\/\/rutgers.box.com\/s\/3o2h0hlidfpw4zybf2rifo9qawl086gn\" target=\"_blank\" rel=\"noopener noreferrer\">Listen to the audio presentation<\/a><\/strong><\/p>\n<p><strong>Title:<\/strong> The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis<\/p>\n<p><strong>Name:<\/strong> Rohit Kumar<\/p>\n<p><strong>Major:<\/strong> Biology<\/p>\n<p><strong>School affiliation:<\/strong> School of Arts and Sciences<\/p>\n<p><strong>Programs:<\/strong> Division of Life Sciences Summer Undergraduate Research Fellowship (DLS-SURF)<\/p>\n<p><strong>Other contributors:<\/strong> Oscar Pell\u00f3n C\u00e1rdenas, Michael P. Verzi<\/p>\n<p><strong>Abstract:<\/strong> Upon complete loss of CDX2, a pro differentiation factor and tumor suppressor, in conjunction with a BRAF V600e mutation, which is the most common BRAF mutation that is implicated in colorectal cancer, there is an upregulation of fetal genes. Essentially, the loss of CDX2 in addition to a BRAF mutation results in progression of oncogenesis while simultaneously reverting the intestine to a fetal like state. While we understand that the intestine becomes more proliferative and stem-like post oncogenic mutation, the mechanism in which this reversion occurs is not clearly identified. GSEA data suggests that loss of CDX2 upregulates both YAP and intestinal stem cell genes. Based on this data, we generated two hypotheses that may address the fetal reversion in the CDX2f\/f; BRAFV600E\/+ mutants post oncogenic mutation. First, we hypothesized that YAP\/TAZ remodel the tumor microenvironment and drive cancer stem cell proliferation. In doing so, the intestine shifts towards a \u201cstem-like state.\u201d We also hypothesized that NRG1 is activated in stromal cells near crypts in response to injury, activating MAPK, and PI3K-AKT signaling. As a result, the intestine supports a regeneration mechanism that promotes proliferation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Listen to the audio presentation Title: The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis Name: Rohit Kumar Major: Biology School affiliation: School of Arts and Sciences &hellip; <a href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/dls-division-of-life-sciences\/kumar-rohit\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":995,"featured_media":0,"parent":3239,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3306","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kumar, Rohit: The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis - Senior Exhibits<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nb-senior-exhibits\/partners\/dls-division-of-life-sciences\/kumar-rohit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kumar, Rohit: The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis - Senior Exhibits\" \/>\n<meta property=\"og:description\" content=\"Listen to the audio presentation Title: The Role of NRG1 and YAP\/TAZ in the Progression of Colorectal Oncogenesis Name: Rohit Kumar Major: Biology School affiliation: School of Arts and Sciences &hellip; 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