{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nyangahu-lab\/?page_id=365"},"modified":"2025-11-18T04:49:36","modified_gmt":"2025-11-18T04:49:36","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Gut microbiota and immunity in infants exposed to HIV<\/strong><\/p>\n

Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk of neurodevelopmental delay compared to those who are HIV unexposed and uninfected(iHUU). The biological mechanisms driving these disparities are poorly understood.<\/p>\n

Our lab investigates whether early-life gut microbiota causally contributes to these adverse outcomes in iHEU infants. We are evaluating if there is a causal relationship between early life gut microbiota in iHEU and these outcomes. We integrate clinical research using samples from mother\u2013infant cohorts with reverse translational studies in preclinical models to uncover potential mechanistic insights linking microbial communities with developmental phenotypes.<\/p>\n

Our goal is to define mechanisms that underlie poorer health outcomes in iHEU, and to leverage these insights to develop microbiota-targeted interventions to improve health outcomes in infants.<\/p>\n","protected":false},"excerpt":{"rendered":"

Gut microbiota and immunity in infants exposed to HIV Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk of … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResearch - Nyangahu Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Nyangahu Lab\" \/>\n<meta property=\"og:description\" content=\"Gut microbiota and immunity in infants exposed to HIV Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk of … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Nyangahu Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-18T04:49:36+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\",\"url\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\",\"name\":\"Research - 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