{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/nyangahu-lab\/?page_id=365"},"modified":"2026-05-17T01:49:15","modified_gmt":"2026-05-17T01:49:15","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p><strong>Gut microbiota and clinical outcomes in infants exposed to HIV<\/strong><\/p>\n<p>Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk of neurodevelopmental delay compared to those who are HIV unexposed and uninfected(iHUU). The biological m<span style=\"font-size: 1rem\">echan<\/span><span style=\"font-size: 1rem\">isms driving these disp<\/span><span style=\"font-size: 1rem\">arities remain poorly understood. <\/span>Our lab studies how early-life gut microbial exposures shape infant immune and developmental outcomes in iHEU. We combine analyses of longitudinal mother\u2013infant cohort samples with mechanistic studies in gnotobiotic and preclinical models to define causal pathways linking the gut microbiota of iHEU with immune development, growth and neurodevelopmental phenotypes.<\/p>\n<p>Our long-term goal is to identify mechanisms driving adverse outcomes in iHEU and develop microbiota-targeted strategies to improve child health.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gut microbiota and clinical outcomes in infants exposed to HIV Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk &hellip; <a href=\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research - Nyangahu Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Nyangahu Lab\" \/>\n<meta property=\"og:description\" content=\"Gut microbiota and clinical outcomes in infants exposed to HIV Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Nyangahu Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-17T01:49:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\",\"url\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\",\"name\":\"Research - Nyangahu Lab\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/#website\"},\"datePublished\":\"2020-07-09T16:56:57+00:00\",\"dateModified\":\"2026-05-17T01:49:15+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/\",\"name\":\"Nyangahu Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/nyangahu-lab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research - Nyangahu Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/nyangahu-lab\/research\/","og_locale":"en_US","og_type":"article","og_title":"Research - Nyangahu Lab","og_description":"Gut microbiota and clinical outcomes in infants exposed to HIV Infants exposed to HIV but uninfected (iHEU), display heightened immune activation, inflammation, compromised growth and are at an elevated risk &hellip; 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