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JWES: Pipeline for WGS & WES data processing, and gene-variant discovery, annotation, prediction, and genotyping

Whole genome and exome sequencing (WGS/WES) are the most popular next-generation sequencing (NGS) methodologies, and are at present often used to detect rare and common genetic variants of clinical significance. We emphasize that automated sequence data processing, management, and visualization should be an indispensable component of modern WGS and WES data analysis for sequence assembly, … Read More

Genomics pipelines to investigate susceptibility in whole genome data for variant discovery

Over the last few decades, genomics is leading toward audacious future, and has been changing our views about conducting biomedical research, studying diseases, and understanding diversity in our society across the human species. The whole genome and exome sequencing (WGS/WES) are two of the most popular next-generation sequencing (NGS) methodologies that are currently being used … Read More

GVViZ: FAIR bioinformatics platform for variable gene-disease annotation, visualization, and expression analysis

Genetic disposition is considered critical for identifying subjects at high risk for disease development. Investigating disease-causing and high and low expressed genes can support finding the root causes of uncertainties in patient care. However, independent and timely high-throughput next-generation sequencing data analysis is still a challenge for non-computational biologists and geneticists. We present a findable, … Read More

Integrative clinical, genomics and metabolomics data analysis for mainstream precision medicine to investigate COVID-19

Despite significant scientific and medical discoveries, the genetics of novel infectious diseases like COVID-19 remains far from understanding. SARS-CoV-2 is a single-stranded RNA respiratory virus that causes COVID-19 by binding to the ACE2 receptor in the lung and other organs. Understanding its clinical presentation and metabolomic and genetic profile will lead to the discovery of … Read More

Artificial intelligence for better healthcare and precision medicine

Precision medicine is one of the recent and powerful developments in medical care, which has the potential to improve the traditional symptom-driven practice of medicine, allowing earlier interventions using advanced diagnostics and tailoring better and economically personalized treatments. Identifying the best pathway to personalized and population medicine involves the ability to analyze comprehensive patient information … Read More

Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis

Precision medicine aims to empower clinicians to predict the most appropriate course of action for patients with complex diseases like cancer, diabetes, cardiomyopathy, and COVID-19. With a progressive interpretation of the clinical, molecular, and genomic factors at play in diseases, more effective and personalized medical treatments are anticipated for many disorders. Understanding patient’s metabolomics and … Read More

Human Gene and Disease Associations for Clinical-Genomics and Precision Medicine.

The time has never been more critical for drug-discovery data and innovative solutions development to open up its secrets for precision medicine to win the battle against Coronavirus disease 19 (COVID-19); a respiratory illness caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite many significant scientific and medical discoveries, the genetics of … Read More

Human gene and disease associations for clinical-genomics and precision medicine research

We are entering the era of personalized medicine in which an individual’s genetic makeup will eventually determine how a doctor can tailor his or her therapy. Therefore, it is becoming critical to understand the genetic basis of common diseases, for example, which genes predispose and rare genetic variants contribute to diseases, and so on. Our … Read More