{"id":1652,"date":"2025-12-01T00:00:58","date_gmt":"2025-12-01T00:00:58","guid":{"rendered":"https:\/\/sites.rutgers.edu\/precision-medicine\/?p=1652"},"modified":"2025-12-01T16:44:05","modified_gmt":"2025-12-01T16:44:05","slug":"intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/","title":{"rendered":"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford"},"content":{"rendered":"

Our article about IntelliGenes<\/em> <\/strong>is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols by the Oxford University Press<\/strong><\/a>.<\/p>\n

\"\"<\/a><\/p>\n

Article: IntelliGenes<\/em>: Interactive and user-friendly multi-modal AI\/ML application for biomarker discovery and predictive medicine<\/strong> <\/a><\/p>\n

Artificial intelligence (AI) and machine learning (ML) have advanced in several areas and fields of life, however, its progress in the field of multi-omics is not matching the levels others have attained. Challenges include but are not limited to the handling and analysis of high volumes of complex multi-omics data, and the expertise needed to implement and execute AI\/ML approaches. In this article, we present IntelliGenes<\/em>, an interactive, customizable, cross-platform, and user-friendly AI\/ML application for multi-omics data exploration to discover novel biomarkers and predict rare, common, and complex diseases. The implemented methodology is based on a nexus of conventional statistical techniques and cutting-edge ML algorithms, which outperforms single algorithms and result in enhanced accuracy. The interactive and cross-platform graphical user interface of IntelliGenes<\/em> is divided into three main sections: 1) Data Manager, 2) AI\/ML Analysis, and 3) Visualization. Data Manager supports the user in loading and customizing the input data and list of existing biomarkers. AI\/ML Analysis allows the user to apply default combinations of statistical and ML algorithms, as well as customize and create new AI\/ML pipelines. Visualization provides options to interpret a diverse set of produced results, including performance metrics, disease predictions, and various charts. The performance of IntelliGenes<\/em> has been successfully tested at variable in-house and peer reviewed studies, was able to correctly classify individuals as patients and predict disease with high accuracy. It stands apart primarily in its simplicity in use for non-technical users and its emphasis on generating interpretable visualizations. We have designed and implemented IntelliGenes<\/em> in a way that a user with or without computational background can apply AI\/ML approaches to discover novel biomarkers and predict diseases.<\/p>\n

IntelliGenes,<\/em> Project Publications:<\/strong><\/p>\n

    \n
  1. Degroat, W., Mendhe, D., Bhurasi, A., Abdelhalim, H., Saman, Z., & Ahmed, Z.*<\/strong> (2023). IntelliGenes<\/em>: A novel machine learning pipeline for biomarker discovery and predictive analysis using multi-genomic profiles<\/a>.<\/strong> Bioinformatics. 39(12), btad755. PMID: 38096588<\/a>. (Oxford).<\/li>\n
  2. Narayanan, R., Degroat, W., Mendhe, D., Abdelhalim, H., & Ahmed, Z.*<\/strong> (2024). IntelliGenes<\/em>: Interactive and user-friendly multimodal AI\/ML application for biomarker discovery and predictive medicine<\/a>.<\/strong> Collection: Artificial Intelligence in Biology and Bioinformatics. Biology Methods & Protocols. 9(1), bpae040. PMID: 38884000<\/a>. (Oxford).<\/li>\n
  3. Narayanan, R., Peker, E., Degroat, W., Mendhe, D., Zeeshan, S., & Ahmed, Z.*<\/strong> (2025). 3D IntelliGenes<\/em>: AI\/ML application using multi-omics data for biomarker discovery and disease prediction with multi-dimensional visualization<\/a>. <\/strong>BMC Medical Research Methodology, Collection: High-dimensional statistics and omics data analysis. PMID: 40781583<\/a> (BMC, Springer Nature)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Our article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols by the Oxford … Read More<\/a><\/p>\n","protected":false},"author":1800,"featured_media":1655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[23,15,17],"tags":[],"class_list":["post-1652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ai-ml","category-precision-medicine","category-publication"],"acf":[],"yoast_head":"\nIntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine<\/title>\n<meta name=\"description\" content=\"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine\" \/>\n<meta property=\"og:description\" content=\"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/\" \/>\n<meta property=\"og:site_name\" content=\"Precision Medicine\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-01T00:00:58+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-01T16:44:05+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1706\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Zeeshan Ahmed\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Zeeshan Ahmed\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/\",\"url\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/\",\"name\":\"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png\",\"datePublished\":\"2025-12-01T00:00:58+00:00\",\"dateModified\":\"2025-12-01T16:44:05+00:00\",\"author\":{\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/77edc84c06f6429b460b13537b586db3\"},\"description\":\"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage\",\"url\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png\",\"contentUrl\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png\",\"width\":1706,\"height\":500},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/\",\"name\":\"Precision Medicine\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/77edc84c06f6429b460b13537b586db3\",\"name\":\"Zeeshan Ahmed\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/656fb48004eb0b5c584fd54f52cc3880?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/656fb48004eb0b5c584fd54f52cc3880?s=96&d=mm&r=g\",\"caption\":\"Zeeshan Ahmed\"},\"url\":\"https:\/\/sites.rutgers.edu\/precision-medicine\/author\/za175\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine","description":"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/","og_locale":"en_US","og_type":"article","og_title":"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine","og_description":"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).","og_url":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/","og_site_name":"Precision Medicine","article_published_time":"2025-12-01T00:00:58+00:00","article_modified_time":"2025-12-01T16:44:05+00:00","og_image":[{"width":1706,"height":500,"url":"http:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png","type":"image\/png"}],"author":"Zeeshan Ahmed","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Zeeshan Ahmed","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/","url":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/","name":"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford - Precision Medicine","isPartOf":{"@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage"},"image":{"@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage"},"thumbnailUrl":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png","datePublished":"2025-12-01T00:00:58+00:00","dateModified":"2025-12-01T16:44:05+00:00","author":{"@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/77edc84c06f6429b460b13537b586db3"},"description":"Article about IntelliGenes is recognized amongst the Most-cited Recent Articles and High-Impact Research within the past two years (2024 & 2025) from Biology Methods & Protocols (Oxford).","breadcrumb":{"@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#primaryimage","url":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png","contentUrl":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-content\/uploads\/sites\/701\/2024\/05\/IntelliGenes_GUI.png","width":1706,"height":500},{"@type":"BreadcrumbList","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/intelligenes-interactive-and-user-friendly-multi-modal-ai-ml-application-for-biomarker-discovery-and-predictive-medicine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.rutgers.edu\/precision-medicine\/"},{"@type":"ListItem","position":2,"name":"IntelliGenes is amongst the Most-cited and High-Impact Research from Biology Methods and Protocols by Oxford"}]},{"@type":"WebSite","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/#website","url":"https:\/\/sites.rutgers.edu\/precision-medicine\/","name":"Precision Medicine","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.rutgers.edu\/precision-medicine\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/77edc84c06f6429b460b13537b586db3","name":"Zeeshan Ahmed","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/precision-medicine\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/656fb48004eb0b5c584fd54f52cc3880?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/656fb48004eb0b5c584fd54f52cc3880?s=96&d=mm&r=g","caption":"Zeeshan Ahmed"},"url":"https:\/\/sites.rutgers.edu\/precision-medicine\/author\/za175\/"}]}},"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/posts\/1652"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/users\/1800"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/comments?post=1652"}],"version-history":[{"count":28,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/posts\/1652\/revisions"}],"predecessor-version":[{"id":2030,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/posts\/1652\/revisions\/2030"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/media\/1655"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/media?parent=1652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/categories?post=1652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/precision-medicine\/wp-json\/wp\/v2\/tags?post=1652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}