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Title
Associate Professor
Area of Study/Expertise
Research
Office Location
675 Hoes Lane R308, Piscataway NJ 08854
Phone Number
732.235.4419
Fax
732.235.7095
Email
mckinnon@rutgers.edu

Randall D McKinnon, PhD

Research - RWJMS and Robert Wood Johnson Medical School

Associate Professor, Department of Neurosurgery

BSc Biology, Queens University, Kingston Canada
Ph.D. Virology, McMaster U., Hamilton Canada
Postdoc, Mol Neurobiology, Scripps Research Inst, La Jolla CA
Staff Scientist, Glial Biology, National Institute of Health, Bethesda

Research Interests:

  • Molecular genetics; transposable genetic elements (Studentship, National Cancer Institute of Canada).
    McKinnon RD., S.Bacchetti, FL.Graham (1982). Tn5 mutagenesis of the transforming genes of human adenovirus type 5. Gene 19: 33-42 [PMID:6754531]
    McKinnon RD., JS Waye, D Bautista, FL Graham (1985). Nonrandom insertion of Tn5 into cloned human adenovirus DNA. Gene 40: 31-38 [PMID:3005126]
    McKinnon RD., P Danielson, MA Brow, FE Bloom, JG Sutcliffe (1987). Expression of small cytoplasmic transcripts of the rat identifier element in vivo and in cultured cells. Mol. Cell. Biol. 7:2148-2154 [PMID: 2439903].
  • Cancer; viral oncogenes(Studentship, Grad Fellowship, National Cancer Institute of Canada).
    Graham, FL, D Rowe, RD McKinnon et al (1984). Transformation by human adenoviruses. J. Cell Phys 3: 151-63.
    McKinnon RD and FL Graham (1986). Transformation of mammalian cells with DNA using the calcium technique. Microinjection and Organelle Transplantation Techniques p.199-214.
  • Stem Cells; glial cell lineage (Sr. Fellowship, US Nat Multiple Sclerosis Society).
    McKinnon RD et al. (1993). A role for TGF-ß in oligodendrocyte development. J. Cell Biol. 121: 1397-1407 [PMID:8509457].
    McKinnon RD et al (1993). Distinct effects of bFGF and PDGF on O-2A progenitor cells. Glia 7: 245-54 [PMID:8454310].
    Ida, J, M.Dubois-Dalcq, RD McKinnon (1993). Expression of the receptor tyrosine kinase c-kit in oligodendrocyte progenitors. J. Neurosci. Res. 36:596-606 [PMID:7511700]
    McMorris, FA, and RD McKinnon (1996). Regulation of oligodendrocyte development and CNS myelination by growth factors: Prospects for therapy of demyelinating disease. Brain Pathology 6:313-29 [PMID: 8864287]
  • Neural Development; Drosophila Neurogenetics(Sabbatical, Salk Institute).
    Yoshikawa S., RD McKinnon, M Kokel, JB Thomas (2003). Wnt-mediated axon guidance through the Drosophila Derailed receptor. Nature 422:583-88 [PMID:12660735]; also News & Views 422:570-71.
    Labrador JP, D.O’Keefe, S Yoshikawa, RD McKinnon, JB Thomas, G Bashaw (2005). The Hox transcription factor even-skipped regulates Netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Current Biol. 15:1413-19 [PMID: 16085495]
  • Growth Factors; RTK Signal Transduction (NIH RO1).
    McKinnon RD, S.Waldron, ME Kiel (2005). PDGFR alpha-Receptor Signal Strength Controls an RTK Rheostat that Integrates PI3’-kinase and PLC-gamma during Oligodendrocyte Maturation. J. Neurosci 25:3499-3508 [PMID:15814780]
  • Cell Transplantation; CNS myelin repair (NMSS; NIH RO1).
    Kiel ME, CP Chen, D Sadowski, RD McKinnon (2008). Stem cell-derived therapeutic myelin repair requires 7% cell replacement. Stem Cells 26 : 2229-36 [PMID:18635868]
    Arriola, AG, ME Kiel, Y Shi, RD McKinnon (2010). Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Research 20:728-31 [Nature Publishing Group, PMID:20440303]
    Sadowski, D, ME Kiel, M Apicella, AG Arriola, CP Chen & RD McKinnon (2010). Teratogenic potential in cultures optimized for oligodendrocyte development from embryonic stem cells. Stem Cells and Development 19, 1343-53 [PMID:20131970]
    Tso D & RD McKinnon (2015). Cell Replacement Therapy CNS Diseases. Neural Regen Research 10:1356-58 [PMID:26604878]
    McKinnon RD (2017). Replacement Cells for CNS Repair: New Tools for Neurology and Neurosurgery. J. Neurology Neurosurg & Spine. Pagano JE, AS Liang, CA Chrzan, RD McKinnon (2017). Peripheral nerve suicide transport generates reproducible SCI. Spine Research 3:18.