Associate Professor | Rutgers RWJMS
Dr. Kim earned his PhD degree for the studies of phospholipid lipases-mediated signal transduction at Pohang University of Science and Technology (POSTECH) in Korea. At POSTECH, Dr. Kim received intense biochemical research training from Drs. Sung Ho Ryu and Pann-Ghill Suh, who discovered major isozymes of Phospholipase C (PLC) and pioneered PLC-mediated signal transduction.
Driven by his interest in signal transduction mechanisms in nerve cells, Dr. Kim joined the laboratory of Dr. Paul Greengard at the Rockefeller University where he received post-doctoral training in molecular and cellular neuroscience research. After completion of his post-doctoral training, Dr. Kim continued to work in the laboratory as a research group leader and collaborated with Dr. Paul Greengard. While at Rockefeller, Dr. Kim investigated molecular and cellular mechanisms associated with the pathophysiology of major depressive disorder, Alzheimer’s disease, and drug addiction. Dr. Kim has published 51 peer-reviewed articles in the area of neuroscience, biochemistry, and cell biology.
Recently, Dr. Kim started a new laboratory as an Associate Professor in the Department of Neurosurgery, Robert Wood Johnson Medical School at Rutgers University, where he studies the molecular and cellular compensatory or repair mechanisms in the brain by which neurons, neuroglia, and the vasculature system maintain homeostasis in response to brain injury or risk factors of neurodegenerative diseases or psychiatric disorders.
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Education:
Doctorate:
Ph.D., Life Sciences, Signal Transduction, Pohang University of Science and Technology, Korea
Post Doctorate:
Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
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Awards:
- Alzheimer’s focused Administrative Supplement Award (NIH/ National Institute of Mental Health) (2023)
- R21 Award (NIH/ National Institute of Neurological Disorders and Stroke) (2023)
- American Epilepsy Society Seed Grant Award (2021)
- Busch Biomedical Grant Award (Rutgers University) (2021)
- R01 Award (NIH/ National Institute of Mental Health) (2019)
- Research Grant Award (US Army Medical Research and Materiel Command) (2009)
- Excellence in Science (NYSTAR: Empire State Development’s Division of Science, Technology and Innovation) (2009)
- Pilot research program funded by NIH/NIDA (Methylphenidate-induced dendritic spine formation) (2008)
- Excellence in Basic Research (Ministry of Education, Science and Technology, Korea) (2006)
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Research Interests:
- Blood-brain barrier function in health and diseases
- Brain cell type-specific compensatory mechanisms in response to βamyloid or tau aggregates.
- Molecular and cellular mechanisms underlying depression and antidepressant actions.
- Common pathways mediating neurological disorders and depression comorbidity.
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Publications:
S100A10 and its binding partners in depression and antidepressant actions,
Chen MX, Oh YS, Kim Y., Front Mol Neurosci;15:953066. doi: 10.3389/fnmol.2022.953066. eCollection, Review. PubMed PMID: 36046712; PubMed Central PMCID: PMC9423026, 2022
Molecular and Cellular Adaptations in Hippocampal Parvalbumin Neurons Mediate Behavioral Responses to Chronic Social Stress,
Bhatti DL, Medrihan L, Chen MX, Jin J, McCabe KA, Wang W, Azevedo EP, Ledo JH, Kim Y., Front Mol Neurosci;15:898851. doi: 10.3389/fnmol.2022.898851. eCollection 2022. PubMed PMID: 35813065; PubMed Central PMCID: PMC9268684, 2022
Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior,
Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y., Mol Psychiatry., May;25(5):1035-1049. doi: 10.1038/s41380-019-0371-y. Epub 2019 Feb 13. PubMed PMID: 30760886; PubMed Central PMCID: PMC6692256, 2020
WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine,
Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y., Proc Natl Acad Sci U S A., Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23. PubMed PMID: 28115704; PubMed Central PMCID: PMC5307471, 2017
Greengard P. Alteration by p11 of mGluR5 localization regulates depression-like behaviors,
Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y., Mol Psychiatry., 2015 Dec;20(12):1546-56. doi: 10.1038/mp.2015.132. Epub 2015 Sep 15. PubMed PMID: 26370144; PubMed Central PMCID: PMC4907335.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production,
Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y., Nat Med. Sep;21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17. PubMed PMID: 26280122; PubMed Central PMCID: PMC4560977, 2015
P11 and its role in depression and therapeutic responses to antidepressants,
Svenningsson P, Kim Y., Warner-Schmidt J, Oh YS, Greengard P., Nat Rev Neurosci., Oct;14(10):673-80. doi: 10.1038/nrn3564. Review. PubMed PMID: 24002251; PubMed Central PMCID: PMC3933996, 2013
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action,
Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, Ahn JH, Chait BT, Patel DJ, Kim Y., Greengard P., Cell., Feb 14;152(4):831-43. doi: 10.1016/j.cell.2013.01.014. PubMed PMID: 23415230; PubMed Central PMCID: PMC3633087, 2013
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines,
Sung JY, Engmann O, Teylan MA, Nairn AC, Greengard P, Kim Y., Proc Natl Acad Sci U S A., Feb 26;105(8):3112-6. doi: 10.1073/pnas.0712180105. Epub 2008 Feb 14. PubMed PMID: 18287015; PubMed Central PMCID: PMC2268593, 2008
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology,
Kim Y., Sung JY, Ceglia I, Lee KW, Ahn JH, Halford JM, Kim AM, Kwak SP, Park JB, Ho Ryu S, Schenck A, Bardoni B, Scott JD, Nairn AC, Greengard P., Nature., Aug 17;442(7104):814-7. doi: 10.1038/nature04976. Epub 2006 Jul 16. PubMed PMID: 16862120; NIHMSID:NIHMS387183, 2006
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Location:
Rutgers, The State University of New Jersey
Staged Research Building
661 Hoes Lane West, Room 132 & 135
Piscataway, NJ 08854