Dr. Kim earned his PhD degree for the studies of phospholipid lipases-mediated signal transduction at Pohang University of Science and Technology (POSTECH) in Korea. Driven by his interest in signal transduction mechanism in nerve cells, Dr. Kim joined the laboratory of Dr. Paul Greengard at the Rockefeller University, where he receivedpost-doctoral training in molecular and cellular neuroscience research. After completion of his post-doctoral training, Dr. Kim continued to work in the laboratory as a research group leader and collaborated with Dr. Paul Greengard. While at Rockefeller, Dr. Kim investigated molecular and cellular mechanisms associated with the pathophysiology of major depressive disorder, Alzheimer’s disease, and drug addiction.
Recently, Dr. Kim started a new laboratory as an Associate Professor in the Department of Neurosurgery, Robert Wood Johnson Medical School at Rutgers University, where he studies molecular and cellular compensatory or repair mechanisms by which neurons, neuroglia or cerebrovascular cells maintain homeostasis in response to brain injury or risk factors of neurodegenerative diseases or psychiatric disorders. Particularly, Dr. Kim is interested in depression and epilepsy comorbidities, and his research team aims to reveal key molecular and cellular pathways mediating comorbidities using transgenic and brain injury animal models. Dr. Kim’s research is currently supported by a Seed Grant from American Epilepsy Society. Dr. Kim has published 53 articles with an h-index of 37 in the areas of neuroscience, biochemistry, and cell biology.
Research Interests:
- Molecular and cellular pathways mediating neurological and psychiatric comorbidities
- Traumatic brain injury-induced depression comorbidity in epilepsy
- Molecular and cellular mechanisms in the regulation of blood-brain barrier permeability
- Homeostatic control of neuronal activity or survival mediated by actin regulators
Publication Highlights:
- Bhatti DL, Medrihan L, Chem MX, Jin J, McCabe KA, Wang W, Azevedo EP, Ledo JH, Kim Y. Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress. Front Mol Neurosci.2022 June. doi: 10.3389/fnmol.2022.898851.
- Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y. Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry. 2020 May;25(5):1035-1049. doi: 10.1038/s41380-019-0371-y. Epub 2019 Feb 13. PubMed PMID: 30760886; PubMed Central PMCID: PMC6692256.
- Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y. WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23. PubMed PMID: 28115704; PubMed Central PMCID: PMC5307471.
- Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard P. Alteration by p11 of mGluR5 localization regulates depression-like behaviors. Mol Psychiatry. 2015 Dec;20(12):1546-56. doi: 10.1038/mp.2015.132. Epub 2015 Sep 15. PubMed PMID: 26370144; PubMed Central PMCID: PMC4907335.
- Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y. APP intracellular domain-WAVE1 pathway reduces amyloid-β production. Nat Med. 2015 Sep;21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17. PubMed PMID: 26280122; PubMed Central PMCID: PMC4560977.
- Svenningsson P, Kim Y, Warner-Schmidt J, Oh YS, Greengard P. p11 and its role in depression and therapeutic responses to antidepressants. Nat Rev Neurosci. 2013 Oct;14(10):673-80. doi: 10.1038/nrn3564. PubMed PMID: 24002251; PubMed Central PMCID: PMC3933996.
- Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, Ahn JH, Chait BT, Patel DJ, Kim Y, Greengard P. SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 2013 Feb 14;152(4):831-43. doi: 10.1016/j.cell.2013.01.014. PubMed PMID: 23415230; PubMed Central PMCID: PMC3633087.
- Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P. Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2915-20. doi: 10.1073/pnas.0813179106. Epub 2009 Feb 6. PubMed PMID: 19202072; PubMed Central PMCID: PMC2650365.
- Sung JY, Engmann O, Teylan MA, Nairn AC, Greengard P, Kim Y. WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A.2008 Feb 26;105(8):3112-6. doi: 10.1073/pnas.0712180105. Epub 2008 Feb 14. PubMed PMID: 18287015; PubMed Central PMCID: PMC2268593.
- Kim Y, Sung JY, Ceglia I, Lee KW, Ahn JH, Halford JM, Kim AM, Kwak SP, Park JB, Ho Ryu S, Schenck A, Bardoni B, Scott JD, Nairn AC, Greengard P. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature. 2006 Aug 17;442(7104):814-7. doi: 10.1038/nature04976. Epub 2006 Jul 16. PubMed PMID: 16862120; NIHMSID:NIHMS387183.