{"id":1360,"date":"2022-12-09T00:14:11","date_gmt":"2022-12-09T00:14:11","guid":{"rendered":"https:\/\/sites.rutgers.edu\/shi-lab\/?p=1360"},"modified":"2023-04-28T15:47:36","modified_gmt":"2023-04-28T15:47:36","slug":"curvature-and-mechanosensing","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/shi-lab\/curvature-and-mechanosensing\/","title":{"rendered":"Curvature and Mechanosensing"},"content":{"rendered":"<p>Shilong found that the shape of cell membrane directly regulates the distribution of Piezo1, a widely expressed mechanosensitive ion channel, within a cell. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics. Read the paper on <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-35034-6\"><em>Nature Communications<\/em><\/a>!<\/p>\n<p>This is a great team work with important contributions from Steven, Boxuan, Huan, and Matthew. Congratulations!<\/p>\n<p>Many thanks to our collaborators from the labs of Charles Cox, Wenting Zhao, and Medha Pathak!<\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">How do the mechanosensitive Piezo1 channels distribute within a cell? In our most recent paper (<a href=\"https:\/\/t.co\/OZS1wlInD5\">https:\/\/t.co\/OZS1wlInD5<\/a>), Shilong <a href=\"https:\/\/twitter.com\/ShilongYang33?ref_src=twsrc%5Etfw\">@ShilongYang33<\/a> looked at the role of membrane curvature. 1\/n <a href=\"https:\/\/t.co\/34FPnOyFbp\">pic.twitter.com\/34FPnOyFbp<\/a><\/p>\n<p>&mdash; Zheng SHI (\u5e08\u5f81) (@ZS_biophys) <a href=\"https:\/\/twitter.com\/ZS_biophys\/status\/1599724859625418753?ref_src=twsrc%5Etfw\">December 5, 2022<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shilong found that the shape of cell membrane directly regulates the distribution of Piezo1, a widely expressed mechanosensitive ion channel, within a cell. Piezo1 may flatten upon activation and can &hellip; <a href=\"https:\/\/sites.rutgers.edu\/shi-lab\/curvature-and-mechanosensing\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":790,"featured_media":1471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-1360","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1360"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/users\/790"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/comments?post=1360"}],"version-history":[{"count":4,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1360\/revisions"}],"predecessor-version":[{"id":1440,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1360\/revisions\/1440"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/media\/1471"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/media?parent=1360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/categories?post=1360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/tags?post=1360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}