{"id":1774,"date":"2025-07-09T03:43:08","date_gmt":"2025-07-09T03:43:08","guid":{"rendered":"https:\/\/sites.rutgers.edu\/shi-lab\/?p=1774"},"modified":"2025-07-09T04:05:51","modified_gmt":"2025-07-09T04:05:51","slug":"drinking-up-the-nucleolus","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/shi-lab\/drinking-up-the-nucleolus\/","title":{"rendered":"&#8220;Drinking up&#8221; the nucleolus"},"content":{"rendered":"<p>In collaboration with Cliff Brangwynne and Howard Stone&#8217;s groups, Holly, James, and Huan studied the mechanics of the nucleolus &#8211; the very core of a eukaryotic cell and a multi-layered condensate.<\/p>\n<p>Check out the video below that nicely demonstrates the liquid nature of the outer GC layer (magenta) and the more solid behavior of the inner DFC layer (green):<\/p>\n<div style=\"width: 92px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-1774-1\" width=\"92\" height=\"432\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"http:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/pnas.2407423122.sm02.mp4?_=1\" \/><a href=\"http:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/pnas.2407423122.sm02.mp4\">http:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/pnas.2407423122.sm02.mp4<\/a><\/video><\/div>\n<p>The project was initiated when Holly (at the time an undergrad in Cliff&#8217;s lab) visited us in the summer of 2022!<\/p>\n<p><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2407423122\" target=\"_blank\" rel=\"noopener\">Read the paper on <em><strong>PNAS!<\/strong><\/em><\/a><\/p>\n<p><em>P.S., Here is a picture of all the authors amused by the idea that micropipette aspiration of the nucleolus is analogous to drinking bubble tea with a straw \ud83d\ude42<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1786\" src=\"http:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q.jpg\" alt=\"\" width=\"683\" height=\"271\" srcset=\"https:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q.jpg 2000w, https:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q-300x119.jpg 300w, https:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q-1024x407.jpg 1024w, https:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q-768x305.jpg 768w, https:\/\/sites.rutgers.edu\/shi-lab\/wp-content\/uploads\/sites\/378\/2025\/07\/bafkreici5trc6aafwvirwdi6xnhfscudmuaz6rxsmgw56iyyxsi5hbzb4q-1536x610.jpg 1536w\" sizes=\"(max-width: 683px) 100vw, 683px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In collaboration with Cliff Brangwynne and Howard Stone&#8217;s groups, Holly, James, and Huan studied the mechanics of the nucleolus &#8211; the very core of a eukaryotic cell and a multi-layered &hellip; <a href=\"https:\/\/sites.rutgers.edu\/shi-lab\/drinking-up-the-nucleolus\/\" class=\"\">Read More<\/a><\/p>\n","protected":false},"author":790,"featured_media":1777,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-1774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1774"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/users\/790"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/comments?post=1774"}],"version-history":[{"count":7,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1774\/revisions"}],"predecessor-version":[{"id":1790,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/posts\/1774\/revisions\/1790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/media\/1777"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/media?parent=1774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/categories?post=1774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/shi-lab\/wp-json\/wp\/v2\/tags?post=1774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}