{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/shuo-xiao\/?page_id=365"},"modified":"2026-09-18T11:49:44","modified_gmt":"2026-09-18T11:49:44","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/shuo-xiao\/research\/","title":{"rendered":"Research"},"content":{"rendered":"
We are working on multiple exciting, basic, translational, and impactful research projects advancing women’s reproductive health, including biology, medicine, drug development, and toxicology:<\/h5>\n
    \n
  1. \n
    Environmental exposures and women\u2019s reproductive health and fertility<\/h5>\n<\/li>\n
  2. \n
    Female reproductive organoids and organ-on-chip<\/h5>\n<\/li>\n
  3. \n
    Cancer therapy-induced female reproductive toxicity, fertility, and hormone preservation<\/h5>\n<\/li>\n
  4. \n
    Impact of hormone homeostasis in women\u2019s pharmacology and toxicology<\/h5>\n<\/li>\n
  5. \n
    Non-hormonal contraceptive discovery targeting ovulation<\/h5>\n<\/li>\n<\/ol>\n

     <\/p>\n

    \"\"<\/p>\n

    Our research is or has been generously supported by NIH (NIEHS, NICHD), DOD, NSF, Gates Foundation, HESI, Rutgers Office of Research, and EOHSI. Our current projects include:<\/h5>\n

     <\/p>\n

    NIH\/ORWH \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>Woodruff (PI), Xiao (MPI),<\/strong> Zhang, Zhu (MPI)\u00a0\u00a0\u00a0\u00a0 09\/15\/2026-09\/14\/2029<\/p>\n

    Office of Research on Women\u2019s Health (ORWH) \u00a0\u00a0<\/strong><\/p>\n

    Computational Modeling of Female Hormone Homeostasis and Drug Responses<\/p>\n

     <\/p>\n

    NIH R01ES037796\u00a0\u00a0\u00a0 <\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Gaskins (PI), Xiao (MPI)<\/strong>, Demokritou (MPI) \u00a0\u00a0\u00a0\u00a009\/25\/2025 – 07\/31\/2030<\/p>\n

    A transdisciplinary approach to evaluate the effects of wildfire smoke on fertility<\/p>\n

     <\/p>\n

    NIH R01ES035766\u00a0\u00a0\u00a0\u00a0 <\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Xiao (PI)<\/strong>, Zhang (MPI)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a012\/13\/2024 – 10\/31\/2029<\/p>\n

    Ovarian disrupting effects of per- and polyfluoroalkyl substances (PFAS) on gonadotropin-dependent folliculogenesis and ovulation<\/p>\n

     <\/p>\n

    NIH R01HD115810<\/strong>\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Xiao (PI)<\/strong>, Kim (MPI)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a008\/16\/2024 – 05\/31\/2029<\/p>\n

    Oogenic JNK in gonadotoxic chemotherapy-induced primary ovarian insufficiency<\/p>\n

     <\/p>\n

    NIH R01HD114750<\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Ye (PI), Xiao (MPI)<\/strong>, Segars (MPI)\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a004\/01\/2024 – 03\/30\/2029<\/p>\n

    Mechanisms of uterine fluid absorption during early pregnancy<\/p>\n

     <\/p>\n

    NIH UG3TR005857\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>German (PI), Xiao (Consultant)<\/strong> \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a008\/15\/2025 – 07\/31\/2028<\/p>\n

    An Organ-on-Chip Approach to Evaluation of Reproductive Health, Aging, and Disease in Women<\/p>\n

     <\/p>\n

    NIH <\/strong>R01ES032144\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Xiao (PI) <\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a009\/20\/2021 – 05\/31\/2026<\/p>\n

    An ovary-on-a-chip to identify ovarian toxicity<\/p>\n

     <\/p>\n

    DOD<\/strong> HT9425-23-1-0809<\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>Xiao (PI)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a010\/01\/2023 – 09\/30\/2026<\/p>\n

    Ovarian disrupting effects and mechanisms of per- and polyfluoroalkyl substances<\/p>\n","protected":false},"excerpt":{"rendered":"

    We are working on multiple exciting, basic, translational, and impactful research projects advancing women’s reproductive health, including biology, medicine, drug development, and toxicology: Environmental exposures and women\u2019s reproductive health and … Read More<\/a><\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nResearch - Xiao ReproHealth Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/shuo-xiao\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Xiao ReproHealth Laboratory\" \/>\n<meta property=\"og:description\" content=\"We are working on multiple exciting, basic, translational, and impactful research projects advancing women’s reproductive health, including biology, medicine, drug development, and toxicology: Environmental exposures and women\u2019s reproductive health and … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/shuo-xiao\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Xiao ReproHealth Laboratory\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-18T11:49:44+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/shuo-xiao\/wp-content\/uploads\/sites\/1229\/2024\/06\/follicle-culture.jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/shuo-xiao\/research\/\",\"url\":\"https:\/\/sites.rutgers.edu\/shuo-xiao\/research\/\",\"name\":\"Research - 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