{"id":365,"date":"2020-07-09T16:56:57","date_gmt":"2020-07-09T16:56:57","guid":{"rendered":"http:\/\/sites.rutgers.edu\/tina-liu-lab\/?page_id=365"},"modified":"2024-05-30T17:42:42","modified_gmt":"2024-05-30T17:42:42","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.rutgers.edu\/tina-liu-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Bacteria and archaea are the most abundant organisms on Earth and are connected to myriad aspects of our lives, from helping make the food we eat, to impacting our health and well-being, to shaping the environment we live in. Like us, they also face the threat of infection by their viruses, which are called phages. As a result, microbes have evolved diverse immune systems to protect themselves. CRISPR (c<\/span>lustered r<\/span>egularly i<\/span>nterspaced s<\/span>hort p<\/span>alindromic r<\/span>epeat)-Cas (CRISPR-associated) loci are a class of prokaryotic adaptive immune systems that use RNA-guided effector complexes to defend against phages and other mobile genetic elements. Our lab aims to understand the diverse mechanisms by which CRISPR-Cas systems work, and use these insights to engineer new tools for biotechnology and medicine. We plan to employ versatile approaches, including biochemistry, molecular engineering, molecular, cell, and structural biology, to achieve these aims.<\/p>\n

\"Artist's
Depiction of the Fast Integrated Nuclease Detection in Tandem (FIND-IT) assay in action. Cas13a (yellow) recognizes target RNA and releases the activator molecule (orange), which in turn supercharges Csm6 (gray) to cleave and release the fluorescent reporter (bright green). This leads to generation of a fluorescent signal that can then be detected by a sensor. Artwork by Dr. Margaret Liu (University of Illinois-Chicago).<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Bacteria and archaea are the most abundant organisms on Earth and are connected to myriad aspects of our lives, from helping make the food we eat, to impacting our health … Read More<\/a><\/p>\n","protected":false},"author":3032,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-custom.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nTina Liu Lab - Research<\/title>\n<meta name=\"description\" content=\"Learn more about our research on the molecular mechanisms and diagnostic applications of CRISPR-Cas systems at Rutgers University.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/tina-liu-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tina Liu Lab - 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