{"id":458,"date":"2021-07-01T22:22:36","date_gmt":"2021-07-01T22:22:36","guid":{"rendered":"https:\/\/sites.rutgers.edu\/valvezan-lab\/?p=458"},"modified":"2021-12-18T00:01:01","modified_gmt":"2021-12-18T00:01:01","slug":"alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells","status":"publish","type":"post","link":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/","title":{"rendered":"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d"},"content":{"rendered":"
\n
\n
\n
\n
\n
\n

\"\"<\/h2>\n

This project will test a new strategy for selectively killing a molecular subtype of T-cell acute lymphoblastic leukemia (T-ALL) using drugs that are already being used in humans as safe and well-tolerated immunosuppressants. This strategy exploits a molecular vulnerability that we recently discovered in tumors with abnormal activation of mTOR complex 1 (mTORC1), which is activated to promote cell growth and proliferation in the majority of human cancers. We discovered that tumor cells with active mTORC1 could be selectively killed, without affecting normal cells, in pre-clinical models of a genetic tumor syndrome called Tuberous Sclerosis Complex (TSC), in which tumor growth is driven by high mTORC1 activity. Due to key molecular similarities between cells in TSC tumors and T-ALL, we hypothesize that the same strategy could be effective in killing T-ALL cells in which mTORC1 is activated by specific genetic mutations which are common in leukemia and lymphoma. The use of clinically approved therapeutics means that efficacy in these studies could lead to rapid repurposing of these drugs for leukemia patients.<\/p>\n<\/div>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

This project will test a new strategy for selectively killing a molecular subtype of T-cell acute lymphoblastic leukemia (T-ALL) using drugs that are already being used in humans as safe … Read More<\/a><\/p>\n","protected":false},"author":1649,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-458","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nAlexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab\" \/>\n<meta property=\"og:description\" content=\"This project will test a new strategy for selectively killing a molecular subtype of T-cell acute lymphoblastic leukemia (T-ALL) using drugs that are already being used in humans as safe … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Alexander Valvezan Lab\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-01T22:22:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-18T00:01:01+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721-300x241.png\" \/>\n<meta name=\"author\" content=\"Alexander J. Valvezan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alexander J. Valvezan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/\",\"url\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/\",\"name\":\"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab\",\"isPartOf\":{\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721-300x241.png\",\"datePublished\":\"2021-07-01T22:22:36+00:00\",\"dateModified\":\"2021-12-18T00:01:01+00:00\",\"author\":{\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/e52498214c8225ea061cfd05d9652d77\"},\"breadcrumb\":{\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage\",\"url\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721.png\",\"contentUrl\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721.png\",\"width\":479,\"height\":384},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/#website\",\"url\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/\",\"name\":\"Alexander Valvezan Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/e52498214c8225ea061cfd05d9652d77\",\"name\":\"Alexander J. Valvezan\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/8015eaaa865b772861097a81541267bd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/8015eaaa865b772861097a81541267bd?s=96&d=mm&r=g\",\"caption\":\"Alexander J. Valvezan\"},\"url\":\"https:\/\/sites.rutgers.edu\/valvezan-lab\/author\/av733\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/","og_locale":"en_US","og_type":"article","og_title":"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab","og_description":"This project will test a new strategy for selectively killing a molecular subtype of T-cell acute lymphoblastic leukemia (T-ALL) using drugs that are already being used in humans as safe … Read More","og_url":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/","og_site_name":"Alexander Valvezan Lab","article_published_time":"2021-07-01T22:22:36+00:00","article_modified_time":"2021-12-18T00:01:01+00:00","og_image":[{"url":"http:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721-300x241.png"}],"author":"Alexander J. Valvezan","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Alexander J. Valvezan","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/","url":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/","name":"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d - Alexander Valvezan Lab","isPartOf":{"@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage"},"image":{"@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage"},"thumbnailUrl":"http:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721-300x241.png","datePublished":"2021-07-01T22:22:36+00:00","dateModified":"2021-12-18T00:01:01+00:00","author":{"@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/e52498214c8225ea061cfd05d9652d77"},"breadcrumb":{"@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#primaryimage","url":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721.png","contentUrl":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-content\/uploads\/sites\/659\/2021\/12\/Valvezan-090721.png","width":479,"height":384},{"@type":"BreadcrumbList","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/alexander-valvezan-receives-leukemia-research-foundation-award-for-project-titled-repurposing-impdh-inhibitors-for-selective-targeting-of-pten-deficient-t-all-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.rutgers.edu\/valvezan-lab\/"},{"@type":"ListItem","position":2,"name":"Alexander Valvezan receives Leukemia Research Foundation Award for project titled, \u201cRepurposing IMPDH inhibitors for selective targeting of PTEN-deficient T-ALL cells\u201d"}]},{"@type":"WebSite","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/#website","url":"https:\/\/sites.rutgers.edu\/valvezan-lab\/","name":"Alexander Valvezan Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.rutgers.edu\/valvezan-lab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/e52498214c8225ea061cfd05d9652d77","name":"Alexander J. Valvezan","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.rutgers.edu\/valvezan-lab\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/8015eaaa865b772861097a81541267bd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8015eaaa865b772861097a81541267bd?s=96&d=mm&r=g","caption":"Alexander J. Valvezan"},"url":"https:\/\/sites.rutgers.edu\/valvezan-lab\/author\/av733\/"}]}},"_links":{"self":[{"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/posts\/458"}],"collection":[{"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/users\/1649"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/comments?post=458"}],"version-history":[{"count":2,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/posts\/458\/revisions"}],"predecessor-version":[{"id":486,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/posts\/458\/revisions\/486"}],"wp:attachment":[{"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/media?parent=458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/categories?post=458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.rutgers.edu\/valvezan-lab\/wp-json\/wp\/v2\/tags?post=458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}