How do astrocytes receive orders from neurons? As we continue to elucidate the function of an understudied protein, called Tweety Homolog 1 (TTYH1), we have recently uncovered its role in processing neuron-derived sphingolipids in the endolysosomes of astrocytes. These sphingolipids modulate the catabolic activities in astrocytes in a TTYH1-dependent manner. Read about the story here: <https://www.nature.com/articles/s41467-025-60402-3>.