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Publications

2020 – Present
  1. Pabon A, Bhupana JN, Wong CO. (2024). Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production. Neural Regeneration Research. 20 (3), 671-681. doi: : 10.4103/NRR.NRR-D-23-02095.
  2. Leung HH, Mansour, C, Rousseau M, Nakhla A, Kiselyov K, Venkatachalam K, Wong CO. (2024). Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia. Glia. 72 (2), 433-451. https://doi.org/10.1002/glia.24484
  3. Scoma ER, Da Costa RT, Leung HH, Urquiza P, Guitart-Mampel M, Hambardikar V, Riggs LM, Wong CO, Solesio ME. (2023) Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics. Int J Mol Sci. Sep 8;24(18):13859.
  4. Karagas NE, Gupta R, Rastegari E, Tan KL, Leung HH, Bellen HJ, Venkatachalam K, Wong CO. (2022) Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS. J Neurosci. 2022 Oct 19;42(42):8019-8037. doi: 10.1523/JNEUROSCI.2456-21.2022.
  5. Martelli F, Hernandes NH, Zuo Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Robin C, Venkatachalam K, Perry T, Batterham P, Bellen HJ. (2022) Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies. Elife. 2022 Feb 22;11:e73812. 
  6. Wong CO*, Karagas NE*, Jung J, Wang Q, Rousseau MA, Chao Y, Insolera R, Soppina P, Collins CA, Zhou Y, Hancock JF, Zhu MX, Venkatachalam K. (2021) Regulation of longevity by depolarization-induced activation of PLC-β-IP3R signaling in neurons. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2004253118. doi: 10.1073/pnas.2004253118. * co-first-author
  7. Martelli F, Zhongyuan Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Venkatachalam K, Perry T, Bellen HJ, Batterham P. (2020) Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25840-25850. doi: 10.1073/pnas.2011828117.
  8. Wong CO. (2020) Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes. Int J Mol Sci. 2020 Jul 21;21(14). doi: 10.3390/ijms21145149.
2008 – 2019
  1. Wong CO, Venkatachalam K. (2019) Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapes. Hum Mol Genet. 2019 Aug 15;28(16):2799-2810.
  2. Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. (2019) HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep. 2019 Apr;20(4). doi: 10.15252/embr.201846685.
  3. Wong CO*, Gregory S, Hu H, Chao Y, Sepúlveda VE, He Y, Li-Kroeger D, Goldman WE, Bellen HJ, Venkatachalam K. (2017) Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages. Cell Host & Microbe 21(6):719-730. (cover article)   * corresponding author
  4. Lau OC*, Shen B*, Wong CO*, Tjong YW, Lo CY, Wang HC, Huang Y, Yung WH, Chen YC, Fung ML, Rudd JA, Yao X. (2016) TRPC5 Channels Participate in Pressure-sensing in Aortic Baroreceptor. Nature Communications. 7:11947  * co-first-author
  5. Wong CO, Palmieri M, Akhmedov D, Li J, Chao Y, Broadhead GT, Zhu MX, Collins C, Berdeaux R, Sardiello M, Venkatachalam K. (2015) Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Reports. 12(12):2009-2020.
  6. Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu, MX, Hu H, Venkatachalam K, Hancock JF. (2015) SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. 349(6250):873-6.
  7. Shen B*, Wong CO*#, Lau OC, Woo T, Bai S, Huang Y, Yao X#. (2015) Plasma Membrane Mechanical Stress Activates TRPC5 Channels. PLOS ONE. 10(4): e0122227. * co-first-author, # co-corresponding author
  8. Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K. (2014) A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission. Neuron. 84(4): 764-777. (cover article)
  9. Venkatachalam K, Wong CO, Zhu MX. (2014) The Role of TRPMLs in Endolysosomal Trafficking and Function. Cell Calcium. 58(1):48-56.
  10. Feng X, Huang Y, Lu Y, Xiong J, Wong CO, Yang P, Xia J, Chen D, Du G, Venkatachalam K, Xia X, Zhu MX. (2014) Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem. 289(7):4262-72.
  11. Venkatachalam K, Wong CO, Montell C. (2013) Feast or famine: role of TRPML in preventing cellular amino acid starvation. Autophagy. 9(1):98-100. (cover article)
  12. Wong CO, Li R, Montell C, Venkatachalam K. (2012) Drosophila TRPML is required for TORC1 activation. Curr Biol. 22(17):1616-21.
  13. Chan KH, Li T, Wong CO, Wong KB. (2012) Structural basis for GTP-dependent dimerization of hydrogenase maturation factor HypB. PLoS One. 7(1):e30547.
  14. Wong CO*, Yao X. (2011) TRP channels in vascular endothelial cells. Adv Exp Med Biol. 704:759-80.  * Corresponding author
  15. Ma X, Cheng KT, Wong CO, O’Neil RG, Birnbaumer L, Ambudkar IS, Yao X. (2011) Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells. Cell Calcium. 50(6):502-9.
  16. Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X. (2011) cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 286(22):19439-45.
  17. Wong CO*, Sukumar P*, Beech DJ, Yao X. (2010) Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Arch. 460(1):121-30.  * co-first-author
  18. Wong CO, Huang Y, Yao X. (2010) Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. Br J Pharmacol. 159(7):1486-96.
  19. Ma X, Qiu S, Luo J, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y, Yao X. (2010) Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol. 30(4):851-8.
  20. Chan CM, Tsoi H, Chan WM, Zhai S, Wong CO, Yao X, Chan WY, Tsui SK, Chan HY. (2009) The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function. Int J Biochem Cell Biol. 41(11):2232-9.
  21. Kwan HY, Wong CO, Chen ZY, Dominic Chan TW, Huang Y, Yao X. (2009) Stimulation of histamine H2 receptors activates TRPC3 channels through both phospholipase C and phospholipase D. Eur J Pharmacol. 602(2-3):181-7.
  22. Wong CO*, Yao X. (2008) Cyclic nucleotide-gated channels: a familiar channel family with a new function? Future Cardiol. 4(5):505-15.  * Corresponding author
  23. Shen B, Cheng KT, Leung YK, Kwok YC, Kwan HY, Wong CO, Chen ZY, Huang Y, Yao X. (2008) Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels. J Mol Cell Cardiol. 45(3):437-45.
  24. Cheng KT, Leung YK, Shen B, Kwok YC, Wong CO, Kwan HY, Man YB, Ma X, Huang Y, Yao X. (2008) CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 28(5):913-8.