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Publications

Google Scholar:
https://scholar.google.com/citations?user=h4rxaiYAAAAJ&hl=en

Research articles:

  1. Nakamura M., Fefelova N., Zhai P., Liu T., Aoyagi Keller M., Ikeda S., Del Re1 D., Li H., Xie L.H., Sadoshima J. Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nature Communication. 2023;14:5805
  2. Fefelova N., Wongjaikam S., Sri Harika Pamarthi, Siri-Angkul N., Comollo T., Ivessa A. Chattipakorn N., Chattipakorn S.C., Gwathmey J.K., and Xie L.H. Deficiency of Mitochondrial Calcium Uniporter Abrogates Iron Overload-Induced Cardiac Ferroptosis and Cardiomyopathy in Mice. Basic Research in Cardiology 2023;118:21.
  3. Lillo M.A., Muñoz M.F., Rhana P., Gaul-Muller1, K., Quan J., Shirokova N., Xie L.H., Santana, L., Fraidenraich D., and Contreras J.E. Remodeled Connexin 43 hemichannels alter cardiac excitability and promote arrhythmias. Journal of General Physiology 2023;155:e202213150
  4. Himelman E., Nouet J., Lillo M.A., Chong A., Wehrens X.H.T., Rodney G., Xie L.H., Shirokova A., Contreras J.E., Fraidenraich D. Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice. American Journal of Physiologg- Heart Circ Physiology 2022; 323: H983-H995
  5. Liang F., Zhang K., Ma W., Zhan H., Sun Q., L.H., Zhao Z. Impaired Autophagy and Mitochondrial Dynamics Are Involved in Sorafenib-Induced Cardiomyocyte Apoptosis. Toxicology 2022:481:153348
  6. Pandey V., Xie L.H., Qu Z., Song Z. Mitochondrial contributions in the genesis of delayed afterdepolarizations in ventricular myocytes. Frontier in computational Physiology and Medicine. 2011; 12:744023.
  7. Siri-Angkul N., Song Z., Fefelova N., Gwathmey J.K., Chattipakorn N., Qu, Z, Chattipakorn S.C., and Xie L.H. Activation of TRPC Channel Currents in Iron Overloaded Cardiac Myocytes. Circulation-Arrhythmia and Electrophysiology. 2021; 14(2): e009291.
  8. Pandey V., Xie L.H., Qu , and Song Z. Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model. PLOS computational Biology. 2021; 17:e1008624.
  9. Mareedu S., Pachon R., Jayapalraj T., Fefelova N., Balakrishnan R., Niranjan N., Xie L.H., and Babu G. Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice. American Journal of Physiology-Heart Circ Physiology 2021; 320: H200-H210. selected for APSelcct Award
  10. Venkatesh S., Baljinnyam E., Tong , Yan L., Liu T., Li H., Xie L.H., Nakamura M., Suzuki C.K., Fraidenraich D., and Sadoshima J. Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2020; 320:R547-R562.
  11. Gordan R., Fefelova N., Gwathmey J. K., Xie L.H. Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of The Mitochondrial Permeability Transition Pore. Antioxidants 2020; 9:758.
  12. Himelman E., Lillo M.A., Nouet J., Gonzalez J.P., Zhao Q., Xie L.H., Li H., Liu T., Wehrens X.H.T., Lampe P.D., Fishman G.I., Shirokova N., Contreras J.E., Fraidenraich D. Prevention of Connexin43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. JCI 2020:128190.
  13. Lillo M., Himelman E., Shirokova N., Xie L.H., Fraidenrach D., Contreras J.E. S-nitrosylation of Cx43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice. JCI Insight 2019;4(24):e130091
  14. Song Z., Xie L.H., Weiss J.N., Qu Z. A spatiotemporal ventricular myocyte model incorporating mitochondrial calcium cycling. Biophysical Journal 2019, 117 (12), 2349-2360
  15. Niranjan N., Mareedu S., Tia1, Kodippili K., Fefelova N., Voit A., Xie L.H., Duan D. and Babu G.J. Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy. American Journal of Physiology-Cellular physiology 2019; 317: C813-C824.
  16. Hitscherich P., Xie L.H., Del Re D., and Lee E.J. The effects of macrophages on cardiomyocyte calcium-handling function using in vitro culture models. Physiological Report. 2019; 7: e14137.
  17. Ikeda S., Mizushima W., Sciarretta S., Abdellatif M., Zhai P., Mukai R., Fefelova N., Oka S., Nakamura M., Del Re D., Farrance I., Park J.Y., Tian B., Xie L.H., Kumar M., Hsu C.P., Sadayappan S., Shimokawa H., Lim D.S., and Sadoshima, J. Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte de-differentiation during pressure overload, Circulation Research 2019;124:292-305
  18. Wen H., Zhao Z., Fefelova N., Xie LH. Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes. Frontiers in Physiology, 2018; 9:1785. doi: 10.3389/fphys.2018.01785.
  19. Hitscherich P., Aphale A., Gordan R., Xie L.H., Patra P., Lee E.J. Electroactive graphene composite scaffolds for cardiac tissue engineering. Journal of Biomedical Materials Research: Part A. 2018: 106; 2923-2933
  20. Zhao Z., Kudej RK., Wen H., Fefelova N., Yan L., Vatner D.E., Vatner S.F., Xie L.H. Antioxidant Defense and Protection to Cardiac Arrhythmias: Lessons from a Mammalian Hibernator (Woodchuck). FASEB Journal 2018;32:4229-4240
  21. Xie A., Song Z., Liu H., Zhou A., Shi G., Wang Q., Gu L., Liu M., Xie L.H., Qu, Z., and Dudley S.C. Mitochondrial Ca2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy. JAHA-Journal of the American Heart Association 2018, 7(8). pii: e007805.
  22. Gonzalez P.J., Ramachandran J., Himelman E., Badr M.A., Kang C., Nouet J., Fefelova N., Xie L.H., Shirokova N.,. Contreras J.E., Fraidenraich D. Normalization of connexin 43 protein levels prevents cellular and functional signs of dystrophic cardiomyopathy in mice. Neuromuscular Disorders. 2018; 28:361-372.
  23. Voit A., Patel V., Pachon , Shah V., Bakhutma M., Kohlbrenner E., McArdle J., Dell’Italia L.J., Mendell J.R., Xie L.H., Hajjar R.J, Duan D., Fraidenraich D., and. Babu G.J. Reducing Sarcolipin Expression Mitigates Duchenne Muscular Dystrophy and Associated Cardiomyopathy in Mice. Nature communication 2017: 8: 1068.
  24. Crassous PA, Shu P, Huang C, Gordan R, Brouckaert P, Lampe PD, Xie LH, Beuve A. Newly Identified NO-Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function. J Am Heart Assoc. 2017;6 (12).  PMCID: PMC5778997.
  25. Baljinnyam E., Venkatesh S., Gordan R., Mareedu S., Zhang J, Xie L.H., Azzam E.I., Suzuki C.K., Fraidenraich D. Effect of Densely Ionizing Radiation on Cardiomyocyte Differentiation from Human Induced Pluripotent Stem Cells. Physiological Report. 2017:5; e13308.
  26. Oda K., Umemura M., Sato I., Nagasako , Oyamada C., Baljinnyam E., Katusmata M., Nakakaji R., Xie L.H., Narikawa M., Yamaguchi Y. , Akimoto T., Ohtake M., Fujita T., Yokoyama U., Iwatsubo K., Aihara M. Ishikawa Y. Transient Receptor Potential Cation 3 Channel Regulates Melanoma Proliferation and Migration. J Physiol Sci. 2017 67:497-505
  27. Lizano P., Rashed E., Zhou N., Wen H., Stoll S., Hays T. T., Xie L.H., Depre C., Qiu H.. The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo. Scientific Reports. 2017; 7, 46324.
  28. Zhang F.., Ma X.L., Wang Y.X., He C.C., Tian K., Wang H.G., An D., Heng B., Xie L.H., Liu Y.Q. TPEN, a Specific Zn2+ Chelator, Inhibits Sodium Dithionite and Glucose Deprivation (SDGD)-Induced Neuronal Death by Modulating Apoptosis, Glutamate Signaling, and Voltage-Gated K+ and Na+ Cell Mol Neurobiol.2017; 37:235-250
  29. Gordan R., Fefelova N., Gwathmey J.K., Xie L.H. Involvement of Mitochondrial Permeability Transition Pore (mPTP) in Cardiac Arrhythmias: Evidence from Cyclophilin D Knockout Mice. Cell Calcium 2016;60:363-73
  30. Hitscherich P., Wu S., Gordan R., Xie L.H., Arinzeh T., Lee E.J. The effect of piezoelectric PVDF-TrFE scaffolds on stem cell derived cardiovascular cells. Biotechnology and bioengineering, 2016;113:1577-85
  31. Wang W.M., Liu Z., Liu A.J., Wang Y.X., Wang H.G., An D., Heng B.,Xie L.H., Duan J.L., Liu Y.Q. The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation. CNS Neurosci Ther. 2015; 21:708-17
  32. Gonzalez J.P., Ramachandran J., Xie L.H., Contreras J.E., Fraidenraich D. Selective connexin43 inhibition prevents isoproterenol-induced arrhythmias and lethality in muscular dystrophy mice. Scientific Reports. 2015;5 :13490
  33. Liu Z., Huang Y.Y, Wang Y.X., Wang H.G., Deng F., Heng B., Xie L.H., Liu Y.Q.  Prevention of cell death by the zinc ion chelating agent TPEN in cultured PC12 cells exposed to Oxygen-Glucose Deprivation (OGD) Journal of Trace Elements in Medicine and Biology 2015; 31: 45–52.
  34. Shanmugam M., Li D., Gao S., Fefelova N., Shah V., Voit A., Pachon R., Yehia G., Xie L.H., Babu G.J. Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. PLoS One. 2015; 10:e0115822.
  35. Zhao Z., Babu G.J., Wen ,  Fefelova N., Gordan R., Sui X.,  Yan L., Vatner D.E., Vatner S.F., Xie L.H. Overexpression of Adenylyl Cyclase Type 5 (AC5) Confers a Proarrhythmic Substrate to the Heart. American Journal of Physiology- Heart Circ Physiology. 2015; 308:H240-9
  36. Umemura M., Baljinnyam E., Feske S., De Lorenzo MS., Xie L.H., Feng X., Oda K., Makino A., Fujita T., Yokoyama U., Iwatsubo M., Chen S., Goydos J.S., Ishikawa Y., Iwatsubo K. Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. PLoS One 2014; 9: e89292.
  37. Zhao Z., Gordan R., Wen H., Fefelova N., Zang W.J., Xie L.H. Modulation of intracellular Calcium waves and triggered activities by mitochondrial Ca flux in mouse cardiomyocytes. PLoS One 2013; 8: e80574
  38. Xie L.H., Doye A.A., Conley E., Gwathmey J.K. Sickle Cell Anemia: The Impact of Discovery, Politics, and Business. Journal of Health Care for the Poor and Underserved. 2013; 24: 147-158.
  39. Matsushima S., Kuroda J., Ago T., Zhai P., Park J.Y., Xie L.H., Tian B., Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circulation Research 2013; 449 :133-42
  40. Zhao Z., Fang M., Xiao D., Liu M., Fefelova N., Huang C., Zang W.J., Xie H. Potential Antiarrhythmic Effect of Methyl-3,4,5-Trimethoxycinnamic Acid, an Bioactive Substance from Roots of Polygalae Radix. Biological and Pharmaceutical Bulletin 2013; 36:238-44.
  41. Park M., Vatner S.F., Yan L., Gao S., Yoon G. S., Lee J. A., Xie L.H., Kitsis R.N., Vatner D. E. Caspase Inhibition Prevents Hypertrophy and Improves Cardiac Function with Chronic Pressure Overload. Basic Research in Cardiology. 2013;108:324
  42. Ramachandran J., Schneider J.S., Crassous P.A., Zheng R., Gonzalez J.P., Xie L.H., Beuve A., Fraidenraich D., R. Peluffo D. Nitric Oxide Signaling Pathway in Duchenne Muscular Dystrophy Mice: Upregulation of L-arginine Transporters. Biochemical Journal. 2013;449:133-42
  43. Wang S.J., Xie L.H., Heng B., Liu Y.Q. Classification of potassium and chlorine ionic currents in retinal ganglion cell line (RGC-5) by whole-cell patch clamp. Visual Neuroscience 2012;29:275-82
  44. Zhao Z., Wen , Fefelova N., Allen C., Guillaume N., Xiao D., Gwathmey J.K., Xie L.H. Docosahexaenoic Acid Reduces the Incidence of Early Afterdepolarizations caused by Oxidative Stress in Rabbit Ventricular Myocytes. Frontiers in  Physiology 2012;3:252
  45. Zhao Z., Xie, Wen H., Xiao D., Allen C., Fefelova  N., Dun W., Boyden P.A., Qu Z., Xie L.H. Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells. Cardiovascular Research 2012;95:308-16
  46. Xie L.H., Shanmugam M., Park J.Y., Zhao Z., Wen H., Tian B., Periasamy M., Babu G.J. Ablation of sarcolipin results in atrial remodeling. American Journal of Physiology-Cellular physiology 2012;302:C1762-71
  47. Zhao Z., Wen H., Fefelova N., Allen C., Baba, A., Matsuda, T., Xie L.H. Revisiting the Ionic Mechanisms of Early Afterdepolarizations in Cardiomyocytes: Predominant by Ca Waves or Ca Currents. American Journal of Physiology- Heart Circ Physiology 2012; 302:H1636-44
  48. Baljinnyam , Umemura M., DeLorenzo M.S., Xie L.H., Nowycky M., Iwatsubo M., Chen S., Goydos J. S., Iwatsubo K. G betagamma subunits inhibit Epac-induced melanoma cell migration. BMC Cancer 2011; 11:256,
  49. Zhao Z., Fefelova N., Mayilvahanan S., Bishara P., Babu G., Xie L.H. Angiotensin II Induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling. Journal of Molecular and Cellular Cardiology 2011; 50:128-36
  50. Shanmugam , Gao S., Hong C., Fefelova N., Nowycky M.C., Xie L.H., Periasamy M., Babu G. J. Ablation of Phospholamban and Sarcolipin Results in Cardiac Hypertrophy and Decreased Cardiac Contractility. Cardiovascular Research 2010; 89:353-61
  51. Baljinnyam E., De Lorenzo M.S., Xie L.H., Iwatsubo M., Chen S., Goydos J.S., Nowycky M.C., Iwatsubo K.. Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism. Cancer Research 2010;70:5607-17
  52. Sato D., Xie L.H., Nguyen T.P., Weiss J.N., Qu Z. Irregularly-Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos? Biophysical Journal 2010; 99:765-773
  53. Morita N., Sovari A.A., Xie Y., Fishbein M.C., Mandel W.J., Garfinkel A., Lin S.F., Chen P.S., Xie L.H., Chen F., Qu Z., Weiss J.N., Karagueuzian H.S. Increased Susceptibility of Aged Hearts to Ventricular Fibrillation During Oxidative Stress. American Journal of Physiology-Heart Circ Physiol. 2009; 297:H1594-605
  54. Xie L.H. (correspondence author), Weiss J.N. Arrhythmogenic consequences of intracellular calcium waves. American Journal of Physiology-Heart Circ Physiology 2009;297:H997-H1002
  55. Sato D. *, Xie L.H. *, Sovari A.A., Tran D.X., Morita N., Xie F., Karagueuzian H., Garfinkel A., Weiss J.N., Qu Z. Synchronization of Chaotic Early Afterdepolarizations in the Genesis of Cardiac Arrhythmias. Proceedings of the National Academy of Sciences, USA 2009;106:2983-8 (* co-first author)
  56. Xie L.H., Chen F., Karagueuzian H.S., Weiss J.N. Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling. Circulation Research 2009;104(1):79-86 (commented in Nature Medicine 2010; 16: 648-9)
  57. Xie H. (correspondence author), John S.A., Ribalet B. and Weiss J.N. Phosphatidylinositol-4,5-bisphosphate (PIP2) Regulation of Strong Inward Rectifier Kir2.1 Channels: Multilevel Positive Cooperativity. Journal Physiology (London). 2008, 586; 1833-48. 2008.
  58. de Diego C., Pai R.K., Chen F.,. Xie L.H, De Leeuw J., Weiss J.N., Valderrábano M. Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers. Circulation. 2008:118:2330-7
  59. Xie L.H., Sato D., Garfinkel A., Qu Z, Weiss J. N. Intracellular Ca Alternans: Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake and Leak. Biophysical Journal 2008;95 :3100-10
  60. de Diego C., Pai R.K., Dave A.S., Lynch A., Thu M., Chen F., H. Xie, Weiss J.N., Valderrábano M. Spatially discordant alternans in cardiomyocyte monolayers. American Journal of Physiology-Heart Circ Physiol. 2008; 294: H1417-25
  61. de Diego C., Chen F., Xie L.H., Dave A. S., Thu M., Weiss J.N., Valderrábano M. Cardiac alternans in embryonic mouse hearts. American Journal of Physiology-Heart Circ Physiol. 2008;294:H433-40
  62. Mahajan A., Sato D., Shiferaw Y., Baher A., Xie L.H., Peralta R., Olcese R., Garfinkel A., Qu Z., and Weiss J.N. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophysical Journal 94: 411-23,
  63. Mahajan A., Shiferaw Y., Sato D., Baher A., Olcese R., Xie L.H., Yang J., Karma A., Chen P.S., Garfinkel A., Qu Z., and Weiss J.A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical Journal 2008;94:392-410
  64. Chen F., De Diego C., Xie L.H., Yang J.H., Klitzner T. S, Weiss J.N. Arrhythmias induced by metabolic inhibitors in mouse embryo hearts. American Journal of Physiology-Heart Circ Physiol. 2007;293(4):H2472-8
  65. Ramachandran S., Xie L.H., John S.A, Subramaniam S., Lal R.. Hemichannel initiates oxidative stress and smoking-induced apoptosis. PLoS One 2007; 2:e712
  66. Ruan H., Mitchell S., Vainoriene M., Lou Q., Xie L.H., Ren S., Goldhaber J. I., Wang Y. A Gαi Mediated Mechanism in Cardiac Eletrophysiological Remodeling and Arrhythmia in Hypertrophic Cardiomyopathy. Circulation Research 2007; 116(6):596-605
  67. Ribalet B., John S. A., Xie L.H., and Weiss J. N. ATP-sensitive K channels: Regulation of bursting by the sulfonyurea receptor, PIP2 and regions of Kir6.2. Journal Physiology (London). 2006;571: 303-17
  68. Feng J.M., Hu Y.K., Xie L.H., Colwell C.S., Shao, X.M. Sun X.P., Chen B., Tang H., Campagnoni A.T.. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 2006;24:717-27
  69. Xie L.H., John S., Ribalet B., Weiss J. N. Long polyamines act as co-factors in PIP2 activation of inward rectifier potassium (Kir2.1) channels. Journal of General Physiology. 2005:126:541-549 (Featured in the cover figure).
  70. Goldhaber J.I., Xie L.H., Duong T., Motter C., Khuu K., and Weiss J. N. Action potential duration restitution and alternans in rabbit ventricular myocytes: The key role of intracellular calcium cycling. Circulation Research. 2005;96:459-66
  71. John S.A., Xie L.H., Weiss J.N. Mechanism of inward rectification in Kir channels (letter to the editor). Journal of General Physiology. 2004;123:623-5
  72. Xie L.H. (correspondence author), John S., Ribalet B., Weiss J. N. Regulation of Gating by Negative Charges in the Cytoplasmic Pore in the Kir2.1 Channel. Journal of Physiology (London). 2004;561:159-68
  73. John S.A., Weiss J.N., Xie L.H., Ribalet B. Molecular mechanism for Kir6.2 ATP-dependent closure. Journal of Physiology (London). 2003;552: 23-34
  74. Xie L.H., John S., Weiss J. N. Inward rectification by polyamines in Kir2.1 channels: synergy between blocking components. Journal of Physiology (London). 2003;550:67-82
  75. Xie L.H., John S., Weiss J. N. Spermine block of the strong inward rectifier potassium channel Kir2.1: Dual roles of surface charge screening and pore block. Journal of General Physiology. 2002;120:53-66
  76. Haruna T., Yoshida H., Nakamura T.Y., Xie L.H., Otani H., Ninomiya T., Takano M., Coetzee W.A., Horie M.. a1-Adrenoceptor-mediated breakdown of phosphatidylinosital-4,5-bisphosphate inhibits Pinacidil-activated KATP currents in rat ventricular myocytes. Circulation Research 2002; 91:232-239
  77. Makita T., Horie M., Xie L.H., Okada Y., Sasayama S. Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes. Heart and Vessels. 15:233-9, 2000.
  78. Kono Y., Horie M., Takano M., Otani H., Xie L.H., Akao M., Tsuji K., Sasayama S. The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A. Pflügers Arch-European Journal of Physiology 2000; 440:692-8
  79. Xie L.H., Horie M., Takano M. Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proceedings of the National Academy of Sciences, USA 1999;96: 15292-7
  80. Ishii T.M., Takano M., Xie L.H., Noma A., Ohmori H. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. Journal of Biological Chemistry 1999;274: 12835-9
  81. Xie L.H., Takano M., Kakei M., Noma A. Wortmannin, an inhibitor of phosphatidylinositol kinase, blocks the MgATP-dependent recovery of Kir6.2-SUR2A channel. Journal of Physiology (London) 1999;514: 655-665
  82. Takano M., Xie L.H., Otano H., Hoire M. Cytoplasmic terminus domains of Kir6.x confer different nucleotide–dependent gating on the ATP-sensitive K+ Journal of Physiology (London) 1998;512: 395-406
  83. Xie L.H. (correspondence author), Takano M., Noma A. The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart. British Journal of Pharmacology 1998;123: 599-604
  84. H. Xie, Takano M., Noma A. Development of inwardly rectifying K+ channel family in rat ventricular myocytes. American Journal of Physiology 1997;272: H1741-50
  85. Obayashi K., Horie M., Xie L.H., Tsuchiya K., Kubota A., Ishida H., Sasayama S. Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins. Circulation 1997;95: 197-204
  86. Takano M., Ishii T., Xie L.H. Cloning and functional expression of the rat brain KIR6.2 channel. Japanese Journal of Physiology 1996;46: 491-5
  87. Horie M., Obayashi K., Xie L.H. James A.F, Sasayama S. Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels. Japanese Heart Journal 1996;37: 661-71
  88. Xie L.H., Horie M., James A.F., Watanuki M., Sasayama S. Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes. Pflügers Arch-European Journal of Physiology 1996;431: 533-9
  89. Li J.Y., Xie L.H., Li Q., Guo S.D. Effects of resibufogenin and ouabain on transmembrane action potential and extracellular potassium ion activity during triggered activity in guinea pig ventricular muscle. Acta Biophysics Sinica 1995;11: 37-42
  90. James A.F., Xie L.H., Fujitani Y., Hayashi S., Horie M. Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1. Nature 1994;370: 297-300
  91. Oe H., Xie L.H., Horie M. Inhibitory pathway of cardiac PKA-dependent Cl– conductance via pertussis toxin-sensitive G proteins. Japanese Journal of Physiology. 1994;44:S219-26
  92. Jin B.L., Xie L.H., Chen D.C., Li C.L., Xie J.T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. Methods and Findings in Experimental and Clinical Pharmacology 1993;5: 23-9
  93. Xie L.H. and Xie J.T. Electrophysiological studies of after-depolarizations and arrhythmias in the heart in vivo. Acta Physiologica Sinica 1991;43: 257-64
  94. Xie J.T. and Xie L.H. Can the MAP technique be applied to study triggered activities of the heart? Intracellular evidence in vivo. Methods and Findings in Experimental and Clinical Pharmacology 1990;12: 419-24
  95. Xie J.T., Xie L.H., Li C.L, Liang N., Feng X. Effects of resibufogenin on monophasic action potential and contractile force of rabbit heart in situ. Acta Pharmacologica Sinica 1988;9: 536-538
  96. Xie J.T., Xie L.H., Li C.L., Liang N., Feng X. Resibufogenin-induced delayed afterdepolarization in rabbit heart in situ. Methods and Findings in Experimental and Clinical Pharmacology 1988;10: 475-6

Review articles:

  1. Xie L.H., Fefelova N., Pamarthi S.H., Gwathmey K. Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease. Cells 2022;11: 2726
  2. Siri-Angkul N., Dadfar B., Jaleel R., Naushad J., Parambathazhath J., Doye AA, Xie L.H., and Gwathmey J.K. Calcium and Heart Failure: How Did We Get Here and Where are We Going? International Journal of Molecular Sciences 2021;22:7392
  3. Xie L.H., Gwathmey K., Zhao Z.  Cardiac Adaptation and Cardioprotection against Arrhythmias and Ischemia-Reperfusion Injury in Mammalian Hibernators. Pfluger Arch-European J. Physiology 2021:473:407-416.
  4. Wen H., Gwathmey K. and Xie L.H. Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology. Frontiers in Cardiovascular Medicine 2020;7:24.
  5. Siri-Angkul N., Xie L.H., Chattipakorn C., Chattipakorn N. Cellular Electrophysiology of Iron-Overloaded Cardiomyocytes. Frontiers in Physiology 2018:9:1615
  6. Gordan , Wongjaikam S., Gwathmey J.K.,  Chattipakorn N., Chattipakorn S.C., and  Xie L.H. Involvement of Cytosolic and Mitochondrial Iron in Iron Overload Cardiomyopathy. Heart Failure Review 2018 23:801-816.
  7. Gordan R., Gwathmey J. K., and Xie L.H. Autonomic and endocrine control of cardiovascular function. World Journal of Cardiology 2015; 7: 204-14.
  8. Gordan R., and Xie L.H. Primary Effect of Reactive Oxygen Species on Electrical Remodeling of the Heart. Circulation Journal 2014; 78:1834-6. (Editorial)
  9. Qu Z., Xie L.H., Olcese , Karagueuzia1 H. S., Chen P.S., Garfinkel A., Weiss J.N. Early Afterdepolarizations in Cardiac Myocytes: Beyond Reduced Repolarization Reserve. Cardiovascular Research 2013; 99:6-15.
  10. Wen H., Gwathmey J. K., Xie L.H. Oxidative Stress-Mediated Effects of Angiotensin II in the Cardiovascular System. World Journal of Hypertension 2012;2: 34-44.
  11. Peng , Wang H., Qu C., Xie L.H. (correspondence author), Wicks S.M., Xie J.T. (correspondence author) Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. Chinese Medicine 2012; 7:2 (1-6).
  12. Peng L., Sun S., Xie L.H. (correspondence author), Wicks S. M., Xie J.T (correspondence author). Ginsenoside Re: Pharmacological Effects on Cardiovascular System. Cardiovascular Therapeutics 2012; 30:e183-e188.
  13. Xie L.H. (correspondence author), John S.A., Ribalet B., and Weiss J.N. Activation of inwardly rectifying potassium (Kir) channels by Phosphatidylinosital-4, 5-bisphosphate (PIP2): Interaction with other regulatory ligands. Prog Biophys Mol Biol. 2007;94:320-335.
  14. Ribalet B., John S.A., Xie L.H. and Weiss J.N. Regulation of the ATP-sensitive K channel Kir6.2 by ATP and PIP2. Journal of Molecular and Cellular Cardiology 2005;39:71-77
  15. Wang Y. and Xie L.H. Aftercontraction and Afterdepolarization in the heart. Pacing and Heart 1993; 7;102-104.
  16. Xie J.T., Xie L.H., Xie J., and Hu D., Monophasic action potential and triggered activities in in vivo hearts. Pacing and Heart 1991; 5;155-59.
  17. Xie L.H., Xie J.T., Guo S.D. Ion-sensitive microelectrode technique and its application to cardiac electrophysiology. Physiological Science 1998;8: 505-510