Dr. Karen Schindler is an Associate Professor in the Department of Genetics at Rutgers University, New Jersey. She received a B.S. in Biology from Loyola University, Maryland and a Ph.D. in Biochemistry/Molecular Biology at Thomas Jefferson University. She then completed postdoctoral training with Dr. Richard Schultz at the University of Pennsylvania. Her laboratory investigates the mechanisms by which the Aurora protein kinases regulate chromosome segregation during meiosis, is probing the genetics of recurrent gamete aneuploidy in humans, and is seeking to understand how Sirtuin 7 functions control reproductive longevity. Dr. Schindler was the recipient of 2018 SSR Virendra B. Mahesh New Investigator Award and the 2020 FASEB Excellence in Science Early Career Investigator Award.
Publications
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Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction, Blengini CS and Schindler K, 2022
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Aurora kinase B negatively regulates Aurora kinase A to control maternal mRNA translation in mouse oocytes. , Aboelenain M and Schindler K, 2021
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Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B, Blengini CS, Nguyen AL, Abolelenain M, Schindler K, 2021
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Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes, Kratka C, Drutovic D, Blengini CS, Schindler K, 2022
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Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing, Sun S, Miller M, Wang Y, Tyc KM, Cao X, Scott RT, Tao X, Bromberg Y, Schindler K and Xing J, 2022
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An analog-sensitive allele of Aurora kinase B is lethal in mouse, Vazquez BN, Quartuccio SM, Schindler K, 2021
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MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging, Singh P, Fragoza R, Blengini CS, Tran TN, Pannafino G, Al-Sweel N, Schimenti KJ, Schindler K, Alani EA, Yu H, Schimenti JC, 2021
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Aurora kinase A is essential for meiosis in mouse oocytes, Blengini CS, Ibrahimian P, Vaskovicova M, Drutovic D, Solc P, Schindler K, 2021
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Origins and Mechanisms Leading to Aneuploidy in Human Eggs, Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J, 2021
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Meiosis interrupted: the genetics of female infertility via meiotic failure, Biswas L, Tyc K, El Yakoubi W, Morgan K, Xing J, Schindler K, 2021
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Analysis of DNA variants in miRNAs and miRNA 3’UTR binding sites in female infertility patients, Tyc KM, Wong A, Scott RT, Tao X, Schindler K, Xing J,
Awards & Distinctions
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FASEB Excellence in Science Early-Career Investigator Award
2020
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Rutgers University Faculty-Scholar Award
2019
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Society for the Study of Reproduction Virendra B. Mahesh New Investigator Award
2018
Courses
- Implications of New Genetics
- How to make a good egg- Minicourse