Publications

Complete List of Publications

Selected Reviews

Stock, A.M., Robinson, V.L. and Goudreau, P.N. (2000) Two-component signal transduction. Annu. Rev. Biochem. 69:183-215.

Gao, R., Bouillet, S. and Stock, A.M. (2019) Structural basis of response regulator function. Annu. Rev. Microbiol. 73:175-197.

Selected Publications

Agbekudzi, A., Arapov, T.D., Stock, A.M., and Scharf, B.E. (2024) The dual role of a novel Sinorhizobium meliloti chemotaxis protein CheT in signal termination and adaptation. Mol. Microbiol. Online ahead of print.

Gao, R., Wu, T., and Stock, A.M. (2024) A conserved inhibitory interdomain interaction regulates DNA-binding activities of hybrid two-component systems in Bacteroides. mBio 15:e0122024.

Gao, R., Brokaw, S.E., Li, Z., Helfant, L.J., Wu, T., Malik, M., and Stock, A.M. (2022) Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites. PLoS Comput. Biol. 18:e1010738.

Zhou, Y., Pu, Q., Chen, J., Hao, G., Gao, R., Ali, A., Hsiao, A., Stock, A.M., Goulian, M., and Zhu, J. (2021) Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens. Cell Rep. 37:110147.

Gao, R., Helfant, L.J., Wu, T., Li, Z., Brokaw, S.E., and Stock, A.M. (2021) A balancing act in transcription regulation by response regulators: titration of transcription factor activity by decoy DNA binding sites. Nucleic Acids Res. 49:11537-11549.

Bouillet, S., Wu, T., Chen, S., Stock, A.M., Gao, R. (2020) Structural asymmetry does not indicate hemi-phosphorylation in the bacterial histidine kinase CpxA. J. Biol. Chem. 295:8106-8117. Editor’s Pick with Highlight

Bezar, I.F., Mashruwala, A.A., Boyd, J.M. and Stock, A.M. (2019) Drug-like fragments inhibit agr-mediated virulence expression in Staphylococcus aureus. Sci. Rep. 9:6786.

Gao, R. and Stock, A.M. (2018) Overcoming the cost of positive autoregulation by accelerating the response with a coupled negative feedback. Cell Rep. 24:3061-3071.

Gao, R. and Stock, A.M. (2018) Quantitative analysis of intracellular response regulator phosphatase activity of histidine kinases. Methods Enzymol. 607:301-319.

Gao, R., Godfrey, K.A., Sufian, M.A. and Stock, A.M. (2017) Counterbalancing regulation in response memory of a positively autoregulated two-component system. J. Bacteriol. 199:e00390-17. Featured with Commentary

Gao, R. and Stock, A.M. (2017) Quantitative kinetic analyses of shutting off a two-component system.  mBio 8:e00412-17.

Gao, R. and Stock, A.M. (2015) Temporal hierarchy of gene expression mediated by transcription factor binding affinity and activation dynamics.  mBio 6:e00686-15.

Gao, R. and Stock, A.M. (2013) Evolutionary tuning of protein expression levels of a positively autoregulated two-component system. PLOS Genetics 9:e1003927.

Leonard, P.G., Golemi-Kotra, D. and Stock, A.M. (2013) Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. Proc. Natl. Acad. Sci. USA 110:8525-8530.

Barbieri, C.M., Wu, T. and Stock, A.M. (2013) Comprehensive analysis of OmpR phosphorylation, dimerization and DNA binding supports a canonical model for activation. J. Mol. Biol. 425:1612-1626.

Gao, R. and Stock, A.M. (2013) Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling. Proc. Natl. Acad. Sci. USA 110:672-677.

Leonard, P.G., Bezar, I., Sidote, D.J. and Stock, A.M. (2012) Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry 51:10035-10043.

Tang, Y.T., Gao, R., Havranek, J.J., Groisman, E.A., Stock, A.M. and Marshall, G.R. (2012) Inhibition of bacterial virulence:drug-like molecules targeting the Salmonella enterica PhoP response regulator. Chem. Biol. Drug Des. 79:1007-1017.

Barbieri, C.M., Mack, T.R., Robinson, V.L., Miller, M.T. and Stock, A.M. (2010) Regulation of response regulator autophosphorylation through interdomain contacts. J. Biol. Chem. 285:32325-32335. Paper of the Week with Commentary