Guoqiang is a molecular biologist with excellent logical rational skills and ambitious experimental strategies to discover the fundamental knowledge in life sciences. He joined the Driscoll Lab in September 2014 to study ageing biology and neuroscience with genetic tools. He has collaborated with many labs and personnel in making major breakthroughs in the life sciences.
Current Projects:
(1) The mechanism of exopher production;
(2) The molecular mechanisms to counteract mitochondrial superoxide stress;
(3) Force-responsive biology.
Education/Training:
| Ludong University, China | B.S. | 07/2003 | Biotechnology |
| Nanjing University, China | M.S. | 07/2006 | Biochemistry and Molecular biology |
| Rutgers Biomedical and Health Sciences, Newark, NJ, USA | Ph.D. | 07/2014 | Pharmacology and Physiology |
Publications:
| 1. Woodhouse R. M., Frolows N., Wang G., Hawdon A., Wong E. H. K., Dansereau L. C., Su Y., Adair L. D., New E. J., Philp A. M., Tan W. K., Philp A., Ashe A.. Mitochondrial succinate dehydrogenase (SDHA) function is essential for sperm motility and male fertility. iScience (accepted in 2022)
2. Wang G, Laranjeiro R, LeValley S, Van Raamsdonk JM and Driscoll M. The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response. bioRxiv 2022 Pages 2022.10.10.511563 DOI: 10.1101/2022.10.10.511563 3. Wang Y., Arnold M. L., Smart A. J., Wang G., Morera A., Nguyen K. C., Schweinsberg P. J., Bai G., Cooper J., Hall D.H., Driscoll M., Grant B.D.. Large vesicle extrusion from C. elegans neurons requires phagocytic interaction via the ARF-6 and CED-1/DRAPER pathways. bioRxiv 2022 Pages 2022.07.31.502194 DOI: 10.1101/2022.07.31.502194 4. Wang, G., Sun, L., Reina, C., Song, I., Gabel, C. and Driscoll, M.. CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis. Scientific Reports 2019 Sep 16;9(1):13315. 5. Amrit, F., Naim, N., Ratnappan, R., Loose, J., Mason, C., Steenberge, L., McClendon, T B., Wang, G., Driscoll, M., Yanowitz, J. and Ghazi, A.. The Longevity-Promoting Factor, TCER-1, Widely Represses Stress Resistance and Innate Immunity. Nat Commun. 2019 Jul 17;10(1):3042. 6. Leyva-Díaz, E., Stefanakis, N., Carrera, I., Glenwinkel, L., Wang, G., Driscoll, M. and Hobert, O. Silencing of repetitive DNA is controlled by a member of an unusual Caenorhabditis elegans gene family. 2017 Genetics 207:529-545 7. Wang, G., Mémin, E., Murali, I., Gaspers, L.D.. The Effect of Chronic Alcohol Consumption on Mitochondrial Calcium Handling in Hepatocytes. Biochemical Journal Oct 27, 2016, 473 (21) 3903-3921; DOI:10.1042/BCJ20160255 8. Turner, J.D., Gaspers, L.D., Wang, G., and Thomas, A.P. (2010). Uncoupling protein-2 modulates myocardial excitation-contraction coupling. Circulation research 106, 730-738. 9. Chen, X., Wang, K., Chen, J., Guo, J., Yin, Y., Cai, X., Guo, X., Wang, G., Yang, R., Zhu, L., et al. (2009). In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation. J Biol Chem 284, 5362-5369. 10. Yan, J.B., Wang, G.Q., Du, P., Zhu, D.X., Wang, M.W., and Jiang, X.Y. (2006). High-level expression and purification of Escherichia coli oligopeptidase B. Protein expression and purification 47, 645-650. |
Awards and Distinctions:
2019 Einstein Nathan Shock Aging Center Pilot & Feasibility Award. Co-PI
Keystone Symposia Scholarship, Jan 13 – Jan 17, 2019, in Keystone Resort in Keystone, Colorado
2016 Post-doctoral Cancer Research Fellowship Award from New Jersey Commission on Cancer Research (NJCCR); Jan. 1st, 2016 to Dec. 31st, 2017; $50,000 per year
Travel Award at the ASBMB Special Symposium, entitled Mitochondria: Energy, Signals and Homeostasis, June 27 -29, 2012.
Advisory experiences:
Lab Research Advisor to Undergraduate Student
Aarushi Parikh (2019-2020; Rutgers University)
Julia Li (2019-; Rutgers University)
David Jimenez (2018-2019; Rutgers University)
Payal Shah (2015-2018; Rutgers University)
Vishal Patel (2016-2017; Rutgers University
Senior Thesis Advisor to Undergraduate Student
Sarah Brook – (Henry Rutgers Honors Award, thesis highest honors designation, 2016; Rutgers University)
Kanchi Raval – (thesis highest honors designation, 2020; Rutgers University)