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The most cited:

Herndon, L.A., Schmeissner, P., Dudaronek, J, Listner, K.M., Brown, P.A., Sakano, Y., Paupard, M., Hall, D. and Driscoll, M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. 2002. Nature 419: 808-14.


Selected recent publications:

Arnold, M.L., Cooper, J.F., Androwski, R., Ardeshna, S., Melentijevic, I., Smart, A.J., Guasp, R.J., Nguyen, K.C., Bai, G., Hall, D.H., Grant, B.D., and Driscoll, M. (2023) Intermediate filaments associate with aggresome-like structures and influence rate of cellular expulsion of neuronal disease aggregates. BioRxiv 501714 [Preprint]. Available from:  under revision Nature Communications

Yang, Y., Arnold, M.L., Choy, E. H., Lange, C. M., Poon, K., Broussalian, M., Sun, L.-H., Moreno, T.M., Singh, A., Driscoll, M., Kumsta, C., Hansen, M. (2023) Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain BioRxiv 2022.12.12.520171;  doi: Nature Aging, under review.

Wang, Y., Arnold, ML., Smart, A.J., Wang, G., Morera, A., Nguyen, K.C.,  Schweinsberg, P.J., Bai, G., Cooper, J., Hall, D.H., Driscoll, M., Grant, B.D. 2023. Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell. Elife Mar 2;12:e82227. doi: 10.7554/eLife.82227. PMID 36861960

Onken, B., Sedore, C.A., Coleman-Hulbert, A.L.,  Hall, D. Johnson, E., Jones, E.G., Banse, S.A., Huynh, P., Guo, S.,  Xue, J., Chen, E., Harinath, G., Foulger, A.C., Chao, E.A., Hope, J., Dipa Bhaumik, D., Plummer, W.T., Inman, D., Morshead, M., Guo, M., Lithgow, G.J., Phillips, P.C., and Driscoll, M. 2021. Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes. Aging Cell e13488. doi: 10.1111/acel.13488. PMID: 34837316  Science Editors Choice highlighted in “In Others Journals” section

Cooper, J., Guasp, R., Arnold,  M., Grant, B, and Driscoll, M. 2021. Stress-induced increases in neuronal exopher extrusion requires lipid biosynthesis, FGF and EGF RAS/ERK signaling, PNAS, 18:e2101410118  PMID: 34475208

Laranjeiro, R.; Harinath, G, Pollard, A.K., Gaffney, C.J., Deane, C.S., Vanapalli, S.A., Etheridge, T. Szewczyk, N.J., and Driscoll, M. 2021. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. iScience. 24(2):102105. PMID: 33659873

Rahman, M., Edwards, H., Birze, N., Gabrilska, R., Rumbaugh, K. P., Blawzdziewicz, J., Szewczyk, N. J., Driscoll, M., and Vanapalli, S.A. 2020. NemaLife Chip: A micropillar-based microfluidic culture device optimized for aging studies on crawling C. elegans. Sci. Rep  Oct 1;10(1):16190. doi: 10.1038/s41598-020-73002-6  PMID: 33004810

Onken, B., Kalinava, N., and Driscoll, M. 2020. Gluoconeogenesis and PEPCK are criticalcomponents of healthy aging and Dietary restriction life extension. PLoS Genetics, 16(8):e1008982. doi: 10.1371/journal.pgen.1008982. PMID: 32841230

*Arnold, M.L., *Cooper, J., Grant, B.D., Driscoll, Quantitative approaches for scoring in vivo neuronal aggregate and organelle extrusion in large exopher vesicles in C. elegans. 2020. J Vis Exp. Sep 18;(163). doi: 10.3791/61368.  PMID: 33016946

Abbott M, Banse SA, Melentijevic I, Jarrett CM, Ange JS, Sedore CA, Falkowski R, Blue BW, Coleman-Hulbert AL, Johnson E, Guo M, Lithgow GJ, Phillips PC, Driscoll M. A simplified design for the C. elegans lifespan machine. J Biol Methods. 2020 Oct 26;7(4):e137. doi: 10.14440/jbm.2020.332. eCollection 2020. PMID: 33204740

Wang, G., Sun, L., Reina, C.P., Song, I., Gabel, C.V., Driscoll, M. 2019. Residues in the CED-4 CARD domain can modulate non-apoptotic neuronal regeneration functions independently from apoptosis, Sci. Reports Sep 16;9(1):13315. doi: 10.1038/s41598-019-49633-9. PMID:31527664

Laranjeiro, R., Harinath, G., Hewitt, J.E., Hartman, J.H., Royal, M.A., Meyer, J.N., Vanapalli, S.A., Driscoll, M. 2019. Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability and protects against neurodegeneration. Proc Natl Acad Sci USA. 2019 Nov 19;116(47):23829-23839. PMID:31685639. F1000 recommended.

Arnold, M.L., Smart, A.J., Melentijevic, I., Driscoll, M. 2018.  Trash talk: disposal and remote degradation of neuronal garbage.  BMC Biology doi: 10.1186/s12915-018-0487-6. PMID: 29382333

Plummer, T.W., Harke, J., Lucanic, M. Chen, E., Bhaumik, D., Harinath, G., Coleman-Hulbert, A.L., Dumas, K.J., Onken, B., Johnson, E., Foulger, A.C., Guo, S., Crist, A.B., Presley, M.P., Xue, J., Sedore, C.A., Chamoli, M., Chang, C., Chen, M.K., Angeli, S., Royal, M., Willis, J.H., Edgar, D., Patel, S., Chao, E.A., Kamat, S., Hope, J., Ibanez-Ventoso, C., Kish, J.L., Guo, M.,  Phillips, P., Lithgow, G.J., Driscoll, M.  2017. Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: Conditions and Assays used for Quantifying the Development, Fertility and Lifespan of Hermaphroditic Caenorhabditis Strains Nature Protocols Exchangedoi:10.1038/protex.2016.086

Lucanic, M., Plummer, WT, Chen, E., Harke, J., Foulger JC, Onken, B,  Coleman-Hulbert, AL, Dumas, KJ, Guo, S., Johnson, E., Bhaumik, D., Xue, J., Crist, AB, Presley, MP, Harinath, G., Sedore, CA, Chamoli, M., Kamat, S., Chen, MK, Angeli, S., Chang, C., Willis, JH, Edgar, D, Royal, MA, Chao, EA, Patel, S., Garrett, T., Ibanez-Ventoso, C., Hope, J., Kish, JL, Guo, M, Lithgow, GJ, Driscoll, M., Phillips, P.C., Lithgow, G. 2017.  Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects Nature Communications, 8:14256 doi 10.1038/ncomms1426. PMID: 28220799

Laranjeiro, R., Harinath, G., Braekman, B.P., Driscoll, M. 2017. Single C. elegans swim sessions induce key features of mammalian exercise.  BMC Biol. 15:30. doi: 10.1186/s12915-017-0368-4. PMID: 28395669

Melentijevic, I., Toth, M.L., Arnold, M.L., Guasp, R., Harinath, G. Nguyen, K.C., Taub, D., Parker, A., Neri, C., Gabel, C.V., Hall, D.H., and Driscoll, M. 2017. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress.  Nature 542:367-371. PMID: 2817824.   Selected by F1000 as of exceptional significance in its field.  (6 F1000 citations). 

Ibáñez-Ventoso, C., Herrera, C., Chen, E., Motto, D., and Driscoll M. Automated analysis of C. elegans swim behavior using CeleST software. 2016. J Vis Exp. 2016 Dec 7;(118). doi: 10.3791/54359. PMID: 28060275

Restif, C., Ibanez-Ventoso, C., Vora, M., Guo, S., Metaxas, D. and Driscoll, M. 2014. CeleST: Computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion. PLoS Computational Biology, 0(7):e1003702PMID: 25033081

Vora, M., Shah, M., Ostafi, S., Onken, B., Xue, J., Ni, JZ, Gu, S., and Driscoll, M. 2013. Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan. PLoS Genetics e1003737 PMID: 24009527

Reina, C.P., Driscoll, M., and Gabel, C.V. 2013. Neuronal repair: Apoptotic proteins make good. Worm 2(2):1-6. PMID: 24058867

Toth, M. Melentijevic, I. Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., Herndon L., Bhanot, G., Rongo, C., Hall, D.H., and Driscoll, M. 2012. Neurite sprouting and synapse deterioration in the aging C. elegans nervous system.  J. Neurosci. 32: 8778-90. PMID 22745480

Pinan-Lucarre, B., Gabel, C., Reina, C., Hulme, S.E., Shevkoplyas, S.S., Slone, R.D., Xue, J., Weisberg, S., Whitesides, G., Samuel, A. and Driscoll, M. 2012. The core apoptotic executioner proteins CED-3 and CED-4 promote neuronal regeneration in C. elegans. PLoS Biology, 10(5):e1001331. PMID 22629231

Yu, S. and Driscoll, M. 2011.  EGF signaling comes of age: promotion of healthy aging in C. elegans. Exptl. Gerontol.46:129-134.

Iwasa, H., Yu, S., Xue, J. and Driscoll, M. 2010. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-γ and IP3R activation. Aging Cell 4:490-505.

Onken, B and Driscoll, M. 2010. Metformin induces both a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via an AMPK, LKB1, and SKN-1-dependent mechanism. PLoS One 5:e8758, pp. 1-12.


Monica’s webpage for the full list of publications